Perspectives in Antiinfective Therapy

Description

Front Matter....Pages I-XVII The Challenge of Perspective....Pages 1-4 History and Philosophy of Bayer Parmaceutical Research....Pages 5-11 On Bacteriological Research....Pages 13-17 Background to Robert Koch’s Lecture at the International Congress in Berlin, 1890....Pages 19-21 Front Matter....Pages 23-23 Multiple Penicillin Binding Protein Profiles in Penicillin Resistant Pneumococci: Evidence for the Clonal Nature of Resistance Among Clinical Isolates....Pages 25-41 Antibiotic Uptake into Gram-Negative Bacteria....Pages 42-53 Inhibition of Protein Biosynthesis by Antibiotics....Pages 54-72 Inhibition of DNA Gyrase: Bacterial Sensitivity and Clinical Resistance to 4-Quinolones....Pages 73-84 Front Matter....Pages 85-85 Mechanisms of Antiretroviral Compounds in Inhibition of Viral and Cellular DNA Polymerases....Pages 87-99 Effects of Drugs on Lipids and Membrane Integrity of Fungi....Pages 100-111 Membrane Changes Induced by Praziquantel....Pages 112-123 Mechanisms of Action of Antimalarial Drugs....Pages 124-143 Front Matter....Pages 145-145 Bacterial Adherence in Pathogenicity....Pages 147-155 Haemophilus influenzae Gene Expression and Bacterial Invasion....Pages 156-162 Coordinate Regulation of Bacterial Virulence Genes....Pages 163-174 Front Matter....Pages 175-175 Transposon Transfer of Drug Resistance....Pages 177-185 Bacterial Proteins Involved in Antimicrobial Drug Resistance....Pages 186-195 Persistent Herpes Simplex Virus Infection and Mechanisms of Virus Drug Resistance....Pages 196-212 Front Matter....Pages 213-213 Antiviral Therapy with Small Particle Aerosols....Pages 215-233 Liposomes and Lipid Structures as Carriers of Amphotericin B....Pages 234-244 Front Matter....Pages 213-213 Targeted Liposomes Bearing Sendai for Influenza Envelope Glycoproteins as a Potential Carrier for Protein Molecules and Genes....Pages 245-260 Front Matter....Pages 261-261 Cell-Mediated Immunity, Immunodeficiency and Microbial Infections....Pages 263-277 Neutropenia: Antibiotic Combinations for Empiric Therapy....Pages 278-284 Infection Prevention by Modulation of the Host Flora....Pages 285-294 Enhancement of Resistance in the Immunocompromised Host by Control of Fungal Growth....Pages 295-307 Front Matter....Pages 309-309 Passive Immunotherapy of Infectious Diseases: Lessons from the Past, Directions for the Future....Pages 311-319 T-Cell Mediated Immunopathology in Viral Infections....Pages 320-326 Front Matter....Pages 327-327 Adherence and Proliferation of Bacteria on Artificial Surfaces....Pages 329-338 Current Knowledge of Chlamydia TWAR, an Important Cause of Pneumonia and Other Acute Respiratory Diseases....Pages 339-359 Current Status of Antiviral Chemotherapy for Genital Herpes Simplex Virus Infection: Its Impact on Disease Control....Pages 360-368 Induction and Maintenance Therapy for Opportunistic Infections in Patients with AIDS....Pages 369-372 Front Matter....Pages 373-373 Nucleic Acid Hybridization: A Rapid Method for the Diagnosis of Infectious Diseases....Pages 375-385 New Technology and Immunospecific Reactions in Helminthic Diseases....Pages 386-395 Molecular Targets of Chemotherapeutic Agents Against the Human Immunodeficiency Virus....Pages 396-418 Modern Strategies in the Design of Antimicrobial Agents....Pages 419-435 Front Matter....Pages 437-437 The Future Challenge of Infectious Disease....Pages 439-443 Barriers to Effective Antiinfective Therapy: The Perspective of a Clinical Pharmacologist....Pages 444-450 Optimal Use of Antimicrobial Agents....Pages 451-460 Views of Future Antiinfective Therapy....Pages 461-468 Back Matter....Pages 469-478