Structural Immunology

Description

This book presents a comprehensive overview of important immune molecules and their structure-function relationships. The immune system is highly complex, consisting of a network of molecules, cells, tissues and organs, and the immune reaction is involved in various physiological as well as pathological processes, including development, self-tolerance, infection, immunity, and cancer. Numerous molecules participate in immune recognition, inhibition and activation, and these important immune molecules can be roughly divided into cell surface receptors, intracellular receptors and intracellular signaling molecules. The study of how these immune molecules function at molecular level has laid the foundation for understanding the immune system. The book provides researchers and students with the latest research advances concerning the structural biology of key immune molecules/pathways, and offers immunologists essential insights into how these immune molecules function. Front Matter ....Pages i-xiii Structural Basis for Signaling Through Shared Common γ Chain Cytokines (Huilin Yang, Rakeeb Kureshi, Jamie B. Spangler)....Pages 1-19 MHC Molecules, T cell Receptors, Natural Killer Cell Receptors, and Viral Immunoevasins—Key Elements of Adaptive and Innate Immunity (Jiansheng Jiang, Kannan Natarajan, David H. Margulies)....Pages 21-62 Structures of Immune Checkpoints: An Overview on the CD28-B7 Family (Weifeng Liu, Xingxing Zang)....Pages 63-78 Interleukin-10 Family Cytokines Immunobiology and Structure (Huaxing Wei, Bofeng Li, Anyuan Sun, Feng Guo)....Pages 79-96 Structural Insights into the Interleukin-17 Family Cytokines and Their Receptors (Shenping Liu)....Pages 97-117 Structural Biology of NOD-Like Receptors (Xinru Yang, Guangzhong Lin, Zhifu Han, Jijie Chai)....Pages 119-141 AIM2 Inflammasome Assembly and Signaling (Bing Wang, Yuan Tian, Qian Yin)....Pages 143-155 Structures of RIG-I-Like Receptors and Insights into Viral RNA Sensing (Xiaojiao Fan, Tengchuan Jin)....Pages 157-188 Structural Insight of Gasdermin Family Driving Pyroptotic Cell Death (Jianbin Ruan)....Pages 189-205 NF-κB, IκB, and IKK: Integral Components of Immune System Signaling (Maria Carmen Mulero, Tom Huxford, Gourisankar Ghosh)....Pages 207-226