Nanomedicine: Emerging Prospects

Description

This book highlights the emerging paradigm of nanomedicine, intersecting two burgeoning fields of nanotechnology and medicine. Numerous publications have appeared in the literature over the years, especially in cancer nanomedicine. In a boarder sense, nanomedicine aims to apply the knowledge and tools of nanotechnology in a mission to diagnose early and prevent or treat diseases using biocompatible nanoparticles (NPs). Current research in nanomedicine and its prospects depend on creating new breakthroughs at the nexus of nanomaterials and biological systems, making use of non-toxic NPs and nano/biomaterials as smart theranostic systems for a variety of diseases including cancer, neurodegenerative, orthopedic, and cardiac diseases.  This book provides a review on recent advancements of nanomedicine in the aforementioned emerging areas of nanomedicine.​ Contents 1 Introduction to Nanomedicine 1.1 Nanomedicine 1.1.1 Nanomaterials for Cancer Nanomedicine 1.2 Challenges and Advancements of Nanomaterials for Nanomedicine 1.2.1 Nanomedicine Advancements in Cancer and Neurodegenerative Diseases 1.2.2 Nanomedicine Advancements in Orthopaedics and Cardiovascular Diseases References 2 Cancer Nanomedicine 2.1 Emerging QDs and NPs as Bioimaging Probes 2.1.1 NIR Emitting QDs for Deep-Tissue Bimodal Imaging 2.1.2 Au-NPs and Tripods for Bioimaging and Therapy 2.2 NPs as Drug Carriers 2.2.1 Iron Oxide NPs 2.2.2 Silica-Based Carriers 2.2.3 Graphene and Graphene Oxide as Carriers 2.2.4 Peptide/Polymer Mediated Delivery 2.2.5 Liposomes for Targeted Delivery 2.3 Photothermal Therapy References 3 Nanomedicine for Neurodegenerative Diseases 3.1 Design of NPs for Inhibiting Protein Aggregation 3.1.1 Au NPs 3.1.2 Ceria NPs 3.2 NP-Based Drug Delivery Carriers 3.2.1 Apolipoprotein 3.2.2 Dendrimers, Peptides, and Inorganic NPs 3.3 NP-Based Biosensors for AD Diagnosis References 4 Nanomedicine for Orthopaedics 4.1 Nanoscale Materials for Bone Tissue Regeneration 4.1.1 Natural Polymers Based Scaffolds for Bone Regeneration 4.1.2 Hydroxyapatite and Graphene Oxide Scaffolds for Bone Regeneration 4.1.3 Antibacterial Nanoparticles Coated Orthopaedic Implants 4.2 Hydrogel Scaffolds for Osteogenic Differentiation of Stem Cells 4.2.1 Polymer/Stem Cells Implanted Hydrogels for Cartilage Regeneration 4.3 Nanomedicine for Controlled Orthopaedic Drug Delivery References 5 Nanomedicine for Cardiac Diseases 5.1 Nanomedicine for Diagnostics and Therapeutics of CVDs 5.1.1 Nanomedicine for Cardiac Tissue Repair and Reinforcement 5.1.2 Nanocarriers for Cardiac Delivery of Drugs and MicroRNA 5.2 Nanotechnology Assisted Cardiac Regenerative Medicine 5.2.1 Dextran NPs Assisted Dual Drug Delivery for Cardiac Regeneration 5.2.2 Nanotherapeutic Approach for Alleviating Cardiac Brain Injury 5.2.3 Nanoparticle-Based Composite Patch for Myocardial Infarction References 6 Conclusions and Perspectives References