Molecular Diagnostics in Dermatology and Dermatopathology

Description

Molecular Diagnostics in Dermatology and Dermatopathology presents the basics of molecular biology and molecular diagnostic methods most commonly used in the clinical laboratory, with an emphasis on the concepts and testing most relevant to dermatological diseases. Topics include the integration of newer diagnostic and prognostic techniques with ‘traditional’ histologic approaches, and discussions of regulatory, ethical, legal, economic issues and ‘newer’ technologies. This important diagnostic tool outlines the clinically relevant uses (i.e.; diagnostic, staging and/or prognostic) applications of these techniques in the field of dermatology. Molecular studies that investigate the pathogenesis of skin diseases will be excluded, unless they also have a direct diagnostic utility. The book will be of interest to practicing pathologists, dermatology and pathology residents, dermatologists, and dermatopathologists. Front Matter....Pages i-xiii Introduction to Molecular Diagnostic Testing in Dermatology and Dermatopathology....Pages 1-12 Principles of Molecular Biology....Pages 13-25 Technologies in the Molecular Diagnostics Laboratory....Pages 27-55 Cytogenetics of Primary Skin Tumors....Pages 57-72 Melanocytic Neoplasms I: Molecular Diagnosis....Pages 73-103 Melanocytic Neoplasms II: Molecular Staging....Pages 105-130 Non-Melanoma Skin Cancers and Hereditary Cancer Syndromes....Pages 131-143 Cutaneous Sarcomas and Soft Tissue Proliferations....Pages 145-189 Molecular Determination of Tissue Margins, Clonal Origin, and Histogenesis of Skin Cancers....Pages 191-202 Mycosis Fungoides and Related Lesions....Pages 203-231 Cutaneous Non-MF T-Cell and NK-Cell Lymphoproliferative Disorders....Pages 233-245 Cutaneous B-Cell Lymphomas....Pages 247-262 Leukemia Cutis....Pages 263-281 Inflammatory Disorders of the Skin....Pages 283-310 Infectious Diseases of the Skin I: Dermatophytosis/Onychomycosis....Pages 311-337 Infectious Diseases of the Skin II: Non-Dermatophytic Infections....Pages 339-357 Wound Healing Disorders: Chronic Wounds and Keloids....Pages 359-368 Alopecias....Pages 369-378 Genodermatoses: Inherited Diseases of the Skin....Pages 379-409 Molecular Aspects of Skin Aging....Pages 411-418 Pharmacogenetics and Pharmacogenomics I: Linking Diagnostic Classification to Therapeutic Decisions....Pages 419-441 Pharmacogenetics and Pharmacogenomics II: Genetic Determinants of Drug Responses and Adverse Drug Reactions....Pages 443-452 Regulatory, Legal, Coding, Billing, Reimbursement, and Ethical Considerations for Molecular Diagnostic Testing in Dermatology and Dermatopathology....Pages 453-464 Back Matter....Pages 465-478