A Case-Based Guide to Neuromuscular Pathology
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Description
This book provides a practical guide to the field of neuromuscular pathology including muscle, peripheral nerve, and skin biopsies with biopsy interpretation. Divided into three parts, the book begins with introductory chapters that review muscle, nerve, and skin biopsy indications and procedures, normal muscle and nerve histology, and common muscle and nerve pathology. The 28 myopathy case chapters in Part 2 and 11 neuropathy case chapters in Part 3 illustrate the clinical and pathological features of many neuromuscular diseases, demonstrate the indications and utilities of biopsies, discuss clinical and pathological differential diagnosis, update the individual disease management, and summarize pertinent clinical and pathology pearls for each case. A Case-Based Guide to Neuromuscular Pathology will function as an indispensable reference for neurologists and pathologists looking to understand the utility of muscle, nerve, and skin biopsies. This book will also aid neurology residents, neuromuscular fellows and neuropathology fellows in preparing for questions related to the muscle and nerve pathology in their in-service and board exams. Front Matter ....Pages i-xiv Front Matter ....Pages 1-1 Skeletal Muscle Biopsy Evaluation (Dennis K. Burns)....Pages 3-48 Peripheral Nerve Biopsy Evaluation (Chunyu Cai)....Pages 49-73 Skin Biopsy with Cutaneous Nerve Fiber Evaluation (Lan Zhou)....Pages 75-88 Front Matter ....Pages 89-89 A 20-Year-Old Man with Acute Multi-organ Failure and Rhabdomyolysis (Lan Zhou, Susan C. Shin)....Pages 91-95 A 45-Year-Old Woman with Proximal Limb Weakness and Skin Peeling on Fingertips (Lan Zhou, Susan C. Shin, Chunyu Cai)....Pages 97-108 A 75-Year-Old Man with Slowly Progressive Leg and Hand Weakness (Lan Zhou, Chunyu Cai)....Pages 109-119 A 53-Year-Old Woman with Proximal Limb Weakness and Marked CK Elevation (Lan Zhou, Chunyu Cai)....Pages 121-129 A 61-Year-Old Woman with Progressive Distal Limb and Deltoid Muscle Weakness (Lan Zhou)....Pages 131-136 A 63-Year-Old Woman with Debilitating Muscle Pain (Lan Zhou)....Pages 137-143 A 33-Year-Old Woman with Pain and Swelling in the Right Calf and Persistent Fever (Lan Zhou, Laura K. Stein, Susan C. Shin)....Pages 145-149 A 28-Year-Old Woman with Proximal Limb Weakness and Scapular Winging (Rahul Abhyankar, Chunyu Cai, Jaya R. Trivedi)....Pages 151-157 A 52-Year-Old Man with Proximal Limb Weakness and Hand Stiffness (Lan Zhou, Susan C. Shin)....Pages 159-166 A 51-Year-Old Woman with Long-Standing Exercise Intolerance (Lan Zhou)....Pages 167-174 A 37-Year-Old Woman with Leg Weakness and CK Elevation (Elisabeth Golden, Lan Zhou)....Pages 175-184 A 25-Year-Old Woman with Droopy Eyelids and Double Vision (Lan Zhou, Chunyu Cai)....Pages 185-194 A 58-Year-Old Man with Hypercapnic Respiratory Failure (Lan Zhou, Patrick Kwon, Susan C. Shin)....Pages 195-202 A 65-Year-Old Man with Asymmetrical Leg Weakness and Foot Tingling (Lan Zhou, Chunyu Cai)....Pages 203-211 A 40-Year-Old Man with Muscle Pain and Fatigue (Lan Zhou)....Pages 213-220 A 42-Year-Old Woman with Progressive Limb Weakness and Breathing Difficulty (Lan Zhou, Dennis K. Burns)....Pages 221-227 A 49-Year-Old Man with Limb Weakness and Painful Skin Lesions (Kara Stavros, Rajeev Motiwala, Lan Zhou, Susan C. Shin)....Pages 229-232 A 54-Year-Old Man with Progressive Lower Limb Weakness and CK Elevation (Lan Zhou)....Pages 233-241 A 63-Year-Old Man with Progressive Limb Weakness and Slurred Speech (Lan Zhou, Susan C. Shin)....Pages 243-250 A 6-Year-Old Girl with Muscle Pain and Swelling in the Thighs (Diana P. Castro, Chunyu Cai, Dustin Jacob Paul)....Pages 251-256 A 4-Year-Old Boy with Progressive Weakness, Difficulty Walking and Running, and Increased Falls (Diana P. Castro, Chunyu Cai, Dustin Jacob Paul)....Pages 257-262 A 2-Year-Old Girl with Hypotonia Since Birth and Delayed Motor and Speech Development (Diana P. Castro, Chunyu Cai, Dustin Jacob Paul)....Pages 263-268 An 8-year-old boy with delayed motor milestones and proximal leg muscle weakness (Partha S. Ghosh, Hart G. W. Lidov)....Pages 269-274 A 6-Year-Old-Boy with Proximal Leg Muscle Weakness and Facial Weakness (Partha S. Ghosh, Hart G. W. Lidov)....Pages 275-281 A 6-Week-Old Boy with Neonatal Hypotonia and Feeding and Respiratory Difficulties (Partha S. Ghosh, Hart G. W. Lidov)....Pages 283-288 A 6-Year-Old Boy with Respiratory and Feeding Difficulties at Birth, Delayed Gross Motor Milestones, and Facial and Proximal Lower Limb Weakness (Partha S. Ghosh, Chunyu Cai)....Pages 289-296 A 12-Year-Old Girl with a 2-Year History of Progressive Limb Weakness and Difficulties with Exercise (Diana P. Castro, Chunyu Cai, Dustin Jacob Paul)....Pages 297-302 A 3-Month-Old Boy with Generalized Hypotonia, Weakness, Pneumonia and Respiratory Failure (Diana P. Castro, Chunyu Cai, Dustin Jacob Paul)....Pages 303-308 Front Matter ....Pages 309-309 A 59-Year-Old Woman with Subacute Lower Limb Weakness and Painful Paresthesia (Shaida Khan, Chunyu Cai)....Pages 311-317 A 63-Year-Old Man with Nausea, Vomiting, Orthostatic Dizziness, and Distal Limb Paresthesia (Jeffrey L. Elliott, Lan Zhou, Chunyu Cai, Michelle Kaku)....Pages 319-327 A 47-year-old woman with progressive numbness and weakness in the limbs (Lingchao Meng, Yun Yuan, Shan Chen)....Pages 329-334 A 65-Year-Old Woman with Acute Limb Weakness and Worsening of Paresthesia (Susan C. Shin, Michelle Kaku, Lan Zhou)....Pages 335-341 A 34-Year-Old Man with Right Hand and Left Foot Numbness (Sharon P. Nations, Dennis K. Burns)....Pages 343-348 A 64-Year-Old Woman with Progressive Pain, Numbness and Weakness in the Right Lower Limb (Lan Zhou, Susan Morgello, Rajeev Motiwala, Susan C. Shin)....Pages 349-356 A 68-Year-Old Man with Progressive Lower Limb Numbness and Weakness and Urinary Incontinence (Lan Zhou, Susan Morgello, Susan C. Shin)....Pages 357-363 A 53-Year-Old Woman with Pain, Burning, Tingling, and Numbness in the Distal Limbs (Lan Zhou)....Pages 365-373 A 40-Year-Old Woman with Patchy Painful Paresthesia (Lan Zhou)....Pages 375-380 A 39-Year-Old Woman with Intermittent Bilateral Foot and Leg Pain since Childhood (Ryan Castoro, Jun Li, Lan Zhou)....Pages 381-387 A 35-Year-Old Man with Pain and Numbness in the Left Lateral Thigh (Lan Zhou)....Pages 389-394 Back Matter ....Pages 395-408
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