Pathogen Genomics: Impact on Human Health

Description

Genome sequencing and analysis have yielded a rich harvest of fundamental information about pathogenesis and have raised significant new possibilities for effective therapeutic intervention. In Pathogen Genomics: Impact on Human Health, a panel of leading infectious disease researchers and pharmaceutical scientists comprehensively review the latest genomic technologies and their application to infectious disease prevention, diagnosis, and treatment. The authors' cross-disciplinary approach-with expertise acquired from studying disease-causing viruses, bacteria, fungi, and protozoa-reveals how sequence information from diverse pathogens has uncovered novel targets for drug discovery, antigenic determinants for vaccine development, as well as diagnostic tools. The authors also discuss the application of DNA microarrays and the impact of genome sequencing comparisons to the discovery and choices of novel drug targets. The result is a better understanding of how these tools can be used to explore the fundamentals of microbial pathogenesis, as well as how pathogens interact with each other and with their host environments. Broad-ranging and illuminating, Pathogen Genomics: Impact on Human Health offers today's infectious disease specialists an authoritative analysis of the new genomic technologies and their productive application to drug discovery, vaccine development, and diagnostics. Front Matter....Pages i-xv Front Matter....Pages xvii-xvii Antiviral Drug Target Discovery with DNA Microarrays....Pages 1-11 Chipping Away at HIV Pathogenesis....Pages 13-24 Microarray Analysis of Human Papillomavirus Pathogenesis....Pages 25-38 Ribozymes as Gene Therapeutic Agents for HIV/AIDS....Pages 39-51 Front Matter....Pages N1-N1 Genomics and New Technologies Applied to Antibacterial Drug Discovery....Pages 53-68 Genomics of the Mycobacterium tuberculosis Complex and BCG Vaccines....Pages 69-81 Bacterial “Genes-to-Screens” in the Post-Genomic Era....Pages 83-96 DNA Microarray Expression Analysis in Antibacterial Drug Discovery....Pages 97-112 The Influence of Genomics on the Molecular Epidemiology of Nosocomial Pathogens....Pages 113-131 Borrelia Genomics as a Tool for Studying Pathogenesis and Vaccine Development....Pages 133-154 Front Matter....Pages N3-N3 Antifungal Target Discovery and Evaluation....Pages 155-166 Antifungal Drug Discovery: Old Drugs, New Tools....Pages 167-196 Cryptococcus neoformans....Pages 197-214 Antifungal Target Selection in Aspergillus nidulans ....Pages 215-230 Functional Genomics of Histoplasma capsulatum ....Pages 231-245 Gene-Finding in Coccidioides immitis ....Pages 247-254 Front Matter....Pages N5-N5 Toxoplasma gondii....Pages 255-279 The Molecular Biology and Pathogenicity of Entamoeba histolytica ....Pages 281-302 Back Matter....Pages 303-309