Vitiligo

Description

Since the first edition of this book was published, new knowledge has been gained on Vitiligo. This widely revised and updated second edition, written by worldwide experts in the field, fully reflects this progress. The apparently, simple and poorly symptomatic presentation of the disease has been a strong disadvantage to its study, as compared to other common chronic skin disorders such as psoriasis and atopic dermatitis. A good skin-based angle of attack is also lacking because generalized Vitiligo is clearly epitomizing the view of skin diseases as simple targets of a systemic unknown dysregulation (diathesis). This view has mostly restricted Vitiligo to the manifestation of an auto-immune diathesis and skin events, which are easily detected using skin biopsies in most other situations, have not been precisely recorded, with the argument that a clinical diagnosis was sufficient for the management of the patient with Vitiligo. This richly illustrated second edition reflects the constant international effort to share the information gathered about this disorder at the clinical, pathophysiological and therapeutic levels. Its aim still being to bridge current knowledge at the clinical and investigative level, to point to the many unsolved issues, and to delineate future priorities for research. Front Matter ....Pages i-xvi Front Matter ....Pages 1-1 Historical Aspects of Vitiligo (Yvon Gauthier, Laila Benzekri)....Pages 3-10 Definitions and Classification (Alain Taïeb, Mauro Picardo)....Pages 11-23 Vitiligo: Histopathology, Including Electron Microscopy (Carlo Cota, Daniela Kovacs)....Pages 25-37 Introduction to Clinical Aspects Chapters (Alain Taïeb, Mauro Picardo)....Pages 39-39 Vitiligo/nonsegmental Vitiligo Including Acrofacial and Universalis (Thierry Passeron, Jean-Paul Ortonne, Prasad Kumarasinghe, Alain Taïeb)....Pages 41-51 Segmental Vitiligo (Seung-Kyung Hann, Hsin-Su Yu, Cheng-Che Eric Lan, Ching-Shuang Wu, Yvon Gauthier, Laïla Benzekri et al.)....Pages 53-71 Mixed Vitiligo (Alain Taïeb)....Pages 73-80 Clinically Inflammatory Vitiligo and Rare Variants (Alain Taïeb, Khaled Ezzedine, Julien Seneschal, Ratnam Attili)....Pages 81-91 Halo Nevus, Leucotrichia and Mucosal Vitiligo (Anuradha Bishnoi, Davinder Parsad)....Pages 93-102 Extra-Cutaneous Melanocytes (Tag S. Anbar, Rehab A. Hegazy, Suzan Shalaby)....Pages 103-113 Koebner Phenomenon (Nanja van Geel, Reinhart Speeckaert)....Pages 115-120 Environmental Triggers and Occupational/Contact Vitiligo (Charlotte Vrijman)....Pages 121-124 Vitiligo, Associated Disorders and Comorbidities (Autoimmune-Inflammatory Disorders, Immunodeficiencies, Rare Monogenic Diseases) (Julien Seneschal, Fanny Morice-Picard, Alain Taïeb)....Pages 125-139 Age and Vitiligo: Childhood, Pregnancy and Late-Onset Vitiligo (Steven Thng, Sai Yee Chuah, Emily Yiping Gan)....Pages 141-151 Vitiligo and Skin of Color (Onyeka Obioha, Candrice Heath, Pearl E. Grimes)....Pages 153-161 Vitiligo-Like Lesions in Patients with Metastatic Melanoma Receiving Immunotherapies (Katia Boniface, Julien Seneschal)....Pages 163-167 Evaluation, Assessment, and Scoring (Alain Taïeb, Mauro Picardo)....Pages 169-176 Quality of Life (Anuradha Bishnoi, Davinder Parsad)....Pages 177-180 Defining the Disease: Editor’s Synthesis (Alain Taïeb, Mauro Picardo)....Pages 181-185 Front Matter ....Pages 187-187 Pathophysiology Overview (Mauro Picardo)....Pages 189-192 Methods to Study Vitiligo: Noninvasive Techniques and In Vivo Reflectance Confocal Microscopy (Hee Young Kang, Marco Ardigò)....Pages 193-204 Animal Models (Gisela F. Erf, I. Caroline Le Poole)....Pages 205-223 In Vitro Study of Vitiligo (Maria Lucia Dell’Anna, Muriel Cario-André)....Pages 225-236 Genetics (Richard A. Spritz)....Pages 237-251 Epigenetics (Li Zhou, Henry W. Lim, Qing-Sheng Mi)....Pages 253-264 Melanocyte Homeostasis in Vitiligo (Véronique Delmas, Lionel Larue)....Pages 265-275 Oxidative Stress and Intrinsic Defects (Mauro Picardo, Maria Lucia Dell’Anna)....Pages 277-283 Immunity/Immunopathology (Kirsten C. Webb, Steven W. Henning, I. Caroline Le Poole)....Pages 285-301 Cytokines, Growth Factors, and POMC Peptides (Markus Böhm, Katia Boniface, Silvia Moretti)....Pages 303-312 Regenerating Melanocytes: Current Stem Cell Approaches with Focus on Muse Cells (Mari Dezawa, Kenichiro Tsuchiyama, Kenshi Yamazaki, Setsuya Aiba)....Pages 313-328 Other Defects/Mechanisms (Maria Lucia Dell’Anna, Mauro Picardo)....Pages 329-332 Pathophysiology of Segmental Vitiligo (Nanja van Geel, Carole Van Haverbeke, Reinhart Speeckaert)....Pages 333-336 Editor’s Synthesis (Mauro Picardo, Alain Taïeb)....Pages 337-342 Front Matter ....Pages 343-343 Management Overview (Alain Taïeb, Mauro Picardo)....Pages 345-351 Medical Therapies (Alain Taïeb)....Pages 353-379 Surgical Therapies (Boon Kee Goh)....Pages 381-398 Depigmenting Therapies (Abdulrahman Aljamal, Mohammed Aljamal, Sanjeev Mulekar, Aleissa Ahmed)....Pages 399-409 Combined/Sequential/Integrated Therapies for Vitiligo (Thierry Passeron)....Pages 411-420 Camouflage (Alida DePase, Thomas Jouary)....Pages 421-427 Photoprotection Issues (Alessia Pacifico, Giovanni Leone, Mauro Picardo)....Pages 429-435 Treating the Disease: Age, Gender, Ethnic Skin, and Specific Locations (Savita Yadav, M. Ramam)....Pages 437-450 Psychological Interventions (Panagiota Kostopoulou, Alain Taïeb)....Pages 451-454 Patients’ Perspectives (Jean-Marie Meurant)....Pages 455-462 Discussion on Empirical, Traditional, and Alternative Treatments (Mauro Picardo)....Pages 463-468 Beyond Guidelines (Tag S. Anbar, Rehab A. Hegazy, Amira A. Eid)....Pages 469-479 Editor’s Synthesis and Perspectives (Alain Taïeb, Mauro Picardo)....Pages 481-483 Back Matter ....Pages 485-496