Infectious Causes of Cancer: Targets for Intervention

Description

Recent developments, particularly in molecular biology, have produced fresh insights into how cancer relates to infectious agents, novel tools for its diagnosis, exciting possibilities for vaccines, and new targets for therapy. In Infectious Causes of Cancer: Targets for Intervention, James J. Goedert and a team of leading experimental and clinical researchers provide critical, integrating surveys of those viruses, bacteria, and parasites that are now known to play a major role in cancer-work that opens the way toward novel therapeutic targets. The contributors focus on five types of human carcinogenic infection-herpesviruses, retroviruses, papillomaviruses, hepatitis viruses, and H. pylori-and review in depth the associated malignancies, as well as how these new diagnostic and therapeutic technologies may be implemented. Cutting-edge and cross-disciplinary, Infectious Causes of Cancer: Targets for Intervention provides clinical oncologists and infectious disease specialists, as well as clinical researchers, with insightful reviews of cancer induction by infectious diseases and the high promise of closely targeted new therapeutics and vaccines. Front Matter....Pages i-xxvi Front Matter....Pages 1-1 History of Infectious Disease Oncology, from Galen to Rous....Pages 3-30 Front Matter....Pages 31-31 Overview of Herpesviruses....Pages 33-49 X-Linked Lymphoproliferative Disease....Pages 51-61 Posttransplant Lymphoproliferative Disorder....Pages 63-76 Epstein-Barr Virus and Burkitt’s Lymphoma....Pages 77-92 Epstein-Barr Virus and Nasopharyngeal Carcinoma....Pages 93-111 Hodgkin’s Disease....Pages 113-127 AIDS-Related Lymphoma....Pages 129-143 Leiomyoma and Leiomyosarcoma....Pages 145-159 Kaposi’s Sarcoma and Other HHV-8 Associated Tumors....Pages 161-194 Front Matter....Pages 195-195 Retroviruses and Cancer....Pages 197-210 Adult T-Cell Leukemia/Lymphoma....Pages 211-229 Clonal HIV in the Pathogenesis of AIDS-Related Lymphoma....Pages 231-242 Front Matter....Pages 243-243 Papillomaviruses in Human Cancers....Pages 245-261 Anogenital Squamous Cell Cancer and Its Precursors....Pages 263-287 Human Papilloma Viruses and Cancers of the Skin and Oral Mucosa....Pages 289-309 Front Matter....Pages 311-311 Overview of Hepatitis B and C Viruses....Pages 313-330 Hepatocellular Carcinoma....Pages 331-347 Hepatitis C Virus, B-Cell Disorders, and Non-Hodgkin’s Lymphoma....Pages 349-368 Front Matter....Pages 369-369 Overview of Helicobacter pylori ....Pages 371-388 Front Matter....Pages 369-369 Gastric Adenocarcinoma....Pages 389-410 Gastric Mucosa-Associated Lymphoid Tissue Lymphoma....Pages 411-422 Salmonella typhi/paratyphi and Gallbladder Cancer....Pages 423-434 Schistosoma hematobium and Bladder Cancer....Pages 435-448 Front Matter....Pages 449-449 Does Childhood Acute Lymphoblastic Leukemia Have an Infectious Etiology?....Pages 451-460 Polyoma Viruses (JC Virus, BK Virus, and Simian Virus 40) and Human Cancer....Pages 461-474 In Pursuit of a Human Breast Cancer Virus, from Mouse to Human....Pages 475-487 Back Matter....Pages 489-498