Combinatorial Chemistry: Synthesis, Analysis, Screening

Description

The story of success goes on and on - with a new book on combinatorial chemistry, edited by Gunther Jung! Combinatorial chemistry is a proven time- and resource-saving synthetic method of outstanding importance for industrial processes. Compound libraries help to save time and money, especially in the search for new drugs, and therefore play a pivotal role in solving the problem of the worldwide increasing demand for new and more active drugs. Not only substances, which are of interest for pharmaceutical chemistry, but also materials, catalysts, and biomolecules such as DNA or oligosaccharides are readily available with high structural diversities. The broad scope of combinatorial sciences is reflected by this book, edited by Gunther Jung: The synthetic methods discussed range from solid-phase to solution-phase synthesis, from preparations of small molecules such as amines or alcohols to those of complex biomolecules. Feasible methods, efficient techniques, new trends in automation, and state-of-the-art fast instrumental analytical and screening methods are presented with many practical tips and tricks for everybody working in combinatorial chemistry. This is the book written by specialists for specialists and for everyone aspiring to become an insider! It is an indispensible source of information for researchers working in organic synthesis, catalysis, biochemistry, and biotechnology, pharmaceutical and clinical chemistry, material sciences, and analytical chemistry.Content: Chapter 1 Combinatorial Chemistry (pages 1–34): Dominika TiebesChapter 2 Survey of Solid?Phase Organic Reactions (pages 35–76): Susan E. Booth, C. Marijke Dreef?Tromp, Petro H. H. Hermkens, Jos A. P. A. de Man and Harry C. J. OttenheijmChapter 3 Solution?Phase Combinatorial Chemistry (pages 77–123): Volkhard AustelChapter 4 Combinatorial Chemistry of Multicomponent Reactions (pages 125–165): Ivar Ugi, Alexander Domling and Birgit EbertChapter 5 Solid?Phase Anchors in Organic Chemistry (pages 166–228): Ralf WarrassChapter 6 The Use of Templates in Combinatorial Chemistry for the Solid?Phase Synthesis of Multiple Core Structure Libraries (pages 229–256): Hartmut Richter, Axel W. Trautwein and Gunther JungChapter 7 Combinatorial Synthetic Oligomers (pages 257–290): Alberto BiancoChapter 8 Glycopeptide and Oligosaccharide Libraries (pages 291–318): Phaedria M. St. Hilaire and Morten MeldalChapter 9 RNA and DNA Aptamers (pages 319–333): Michael FamulokChapter 10 Combinatorial Approaches to Molecular Receptors for Chemosensors (pages 334–353): Dietmar Leipert, Jurgen Mack, Rolf Tunnemann and Gunther JungChapter 11 Peptide Libraries in T?Cell?Mediated Immune Response (pages 355–380): B. Fleckenstein, G. Jung and K.?H. WiesmullerChapter 12 Combinatorial Biosynthesis of Microbial Metabolites (pages 381–407): Andreas Bechthold and Jose Antonio Salas FernandezChapter 13 Design and Diversity Analysis of Compound Libraries for Lead Discovery (pages 409–439): Hans Matter and Matthias RareyChapter 14 How to Scale?up while Scaling down: EVOscreen™, a Miniaturized Ultra?High?Throughput Screening System (pages 440–461): Rodney Turner, Sylvia Sterrer, Karl?Heinz Wiesmuller and Franz?Josef Meyer?AlmesChapter 15 High?Throughput Experimentation in Catalysis (pages 463–477): Ferdi Schuth, Christian Hoffmann, Anke Wolf, Stephan Schunk, Wolfram Stichert and Armin BrennerChapter 16 FT?Infrared Spectroscopy and IR?Microscopy On?Bead Analysis of Solid?Phase Synthesis (pages 479–498): Holger Bandel, Wolfgang Haap and Gunther JungChapter 17 Mass Spectrometric Analysis of Combinatorially Generated Compounds and Libraries (pages 499–532): Roderich Su?muth, Axel Trautwein, Hartmut Richter, Graeme Nicholson and Gunther JungChapter 18 High?Resolution Magic Angle Spinning (MAS) NMR Spectroscopy for On?Bead Analysis of Solid?Phase Synthesis (pages 533–542): Ralf Warrass and Guy LippensChapter 19 Automated Combinatorial Chemistry (pages 543–559): Martin Winter, Karl?Heinz Wiesmuller and Gunther JungChapter 20 Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FT?ICR?MS) for Analysis of Compound Libraries (pages 561–581): Tilmann B. Walk, Axel W. Trautwein, Holger Bandel and Gunther Jung