Cancer and Inflammation

Description

How are cancer and inflammation interrelated mechanistically and clinically? Though extensive literature exists on the topic "Cancer and Inflammation", there are relatively few texts that have truly integrated the two in spite of the many common mechanisms shared by their processes. Certainly, areas such as cytokines, growth factors, proliferation, signal transduction and angiogenesis, for example, are found in both. Yet, the dynamics of how these common mechanisms are maybe interrelated in the pathologies of the two is not widely covered. Such coverage, as presented in this volume, may help further understanding and bring new approaches to therapeutics. The first section of the book discusses inflammatory mechanisms, studied in cellular and animal studies. The second part concentrates on clinical studies with antiinflammatory drugs in cancer treatment. The volume is written for biomedical researchers in the health care industry and in academia who are working in these areas. Front Matter....Pages i-ix Chronic inflammation and cancer in various organ systems....Pages 1-20 Cancer as a chronic inflammatory disease: role of immunotherapy....Pages 21-51 Inflammatory chemokines: their role in tumor growth and progression....Pages 53-69 Inflammation and matrix metalloproteinases: implications for cancer development....Pages 71-97 Interplay between inflammation and tumor angiogenesis....Pages 99-121 Apoptotic responses common to cancer and inflammation....Pages 123-145 Cyclooxygenase activity in gastrointestinal cancer development and progression: prospects as a therapeutic target....Pages 147-175 Effects of cyclooxygenase-2 (COX-2) inhibitors in colorectal cancer....Pages 177-187 Inflammation, necrosis, and cancer....Pages 189-196 Back Matter....Pages 197-202