Estrogens and Progestogens in Clinical Practice

Description

This book provides a comprehensive approach to an understanding of all clinical conditions where estrogens and progestogens are involved. It encompasses the underlying science of chemistry, physiology, biochemistry and pharmacology. There is a broad but detailed perspective on the clinical use of estrogens and progestogens in therapy, contraception and hormone replacement therapy. An international line up of contributors provide an up-to-date world view on this subject. Front Cover Dedications Title Page Copyright Contents Contributors Foreword Preface Glossary Plates Section 1: Historical overview 1: The discovery of reproductive steroid hormones and recognition of their physiological roles (Diczfalusy & Fraser) 2: Historical overview of estrogens and progestogens as therapeutic agents (Goldzieher) 3: Drug regulatory testing (Edgren) Section 2: Chemistry 4: Structure–function relationships and metabolism of estrogens and progestogens (Stanczyk) 5: Chemistry of antihormones (Davies) 6: Chemical synthesis (Edwards & Henzl) Section 3: Physiology 7: Biosynthesis and secretion of ovarian and adrenal steroids (Hillier) 8: Metabolism of estrogens and progestogens (Longcope) 9: Feedback mechanisms (Baird) 10: The normal menstrual cycle; changes throughout life (Norman & Phillipson) 11: Action of estrogen and progesterone at the cellular level (Christin-Maitre, Chabbert-Buffet, & Bouchard) 12: The molecular basis for the development of estrogen, and progesterone agonists and antagonists (McDonnell & Wagner) 13: Effects of estrogen and progesterone on the endometrium (Critchley & Healey) 14: Menstruation (Rogers) 15: Effects of estrogen and progesterone on myometrium, cervix, fallopian tube, vagina and vulva (Jansen) 16: Effects of estrogen and progesterone on the breast (Hindle) 17: Effects of estrogen and progesterone on the central nervous system (Polcz, Horvath, & Naftolin) 18: Effects of estrogen and progesterone on bone (Winding, Jorgensen, & Christiansen) 19: Vascular effects of estrogen and progesterone (Miller et al.) 20: Estrogen and progesterone effects on nonreproductive tissues: urinary tract (Johnston & Stanton) 21: Effects of estrogen and progesterone on skin (Brincat & Formosa) 22: Estrogen and progesterone during pregnancy and parturition (Challis & Lye) 23: Estrogens and progesterone in the post-partum period (Illingworth & McNeilly) 24: Estrogen and progesterone in the fetus and neonate (Carr) Section 4: Pharmacology 25: Pharmacokinetics of estrogens and progestogens (Faigle & Schenkel) 26: Pharmacodynamic effects of estrogens and progestogens (Goldzieher) 27: The pharmacology of antiestrogens and antiprogestogens (Davies) Section 5: Laboratory Assessment 28: Assays for estrogens and progestogens (Collins) 29: Imaging of the reproductive tract (Ramsay & Fraser) Section 6: Therapeutics 30: Primary and secondary amenorrhea (Lobo) 31: Primary dysmenorrhea (Akerlund) 32: Secondary dysmenorrhea and chronic pelvic pain (Odukoya, Atkinson, & Cooke) 33: Premenstrual syndrome (Keye) 34: Polycystic ovary syndrome (PCOS) (Lobo) 35: Dysfunctional uterine bleeding (Fraser & Hickey) 36: Defective luteal function (Lessey & Fritz) 37: Endometriosis and adenomyosis (Barbieri) 38: Leiomyomata (Vollenhoven & Healy) 39: The pathophysiology and therapy of benign breast disease (Fentiman) 40: Precocious puberty (Dattani & Brook) 41: Assisted reproductive technologies (Lobo) 42: Use of therapeutic steroids in pregnancy (Matson & Yovich) 43: Fetal effects of estrogens, progestogens and diethylstilbestrol (Simpson & Kaufman) 44: Clinical aspects of oral contraception (Connell) 45: Clinical aspects of the use of long-acting hormonal contraception (Weisberg & Fraser) 46: Antiprogestogens for contraception, interception and medical termination of pregnancy (Norman & Cameron) 47: Demographic aspects (McKinlay & Crawford) 48: Pituitary and ovarian changes (Burger) 49: Hot flashes (Brzechffa & Judd) 50: Psychological effects of menopause (Liao & Hunter) 51: Pharmacological background of estrogen replacement therapy and continuance (Hammond & Blohm) 52: General principles of administration of hormone replacement therapy: indications and contraindications, routes of administration, treatment schedules (Whitehead) 53: Benefits of treatment: local and general menopausal symptoms (Lumsden) 54: Benefits of treatment: osteoporosis (Melton & Khosla) 55: Effects of hormone replacement therapy on the cardiovascular system (McGrohom & Celermajer) 56: Progestogen therapy in malignant tumors of the uterus and ovary (Felix & Kurman) 57: Use of estrogens and progestogens in women with breast cancer (Eden) 58: Sex steroid production from ovarian tumors (Jansen) 59: An overview of side effects (Darney) 60: Non-therapeutic beneficial effects (Kovacs) 61: Effects on carbohydrate metabolism (Godsland) 62: Effects of estrogens and progestogens on plasma lipids and lipoproteins (Crook) 63: Effects on the immunological system (Jones) 64: Psychological, mood and central nervous system effects (Panay, Sands, & Studd) 65: Psychosexual effects (Dennerstein) 66: Effects on other tissues (Goldzieher) 67: The influence of steroids on gynecologic cancers (Schlesselman & Collins) 68: Influence of therapeutic steroids on the incidence and severity of breast cancer (Hankinson & Stampfer) Index