ENGLISH

Transporters as Drug Carriers: Structure, Function, Substrates (Methods and Principles in Medicinal Chemistry)

By Raimund Mannhold , Hugo Kubinyi , Gerd Folkers , Gerhard Ecker , Peter Chiba

Book information

Year
2009
ISBN
3527316612, 9783527316618
Language
english
Format
PDF
Filesize
5 MB (5181831 bytes)
Series
Methods and Principles in Medicinal Chemistry 44
Edition
1
Pages
449\451
Topic
Chemistry
Time added
2011-06-04 13:46:07

Description

This reference handbook is the first to provide a comprehensive overview, systematically characterizing all known transporters involved in drug elimination and resistance. Combining recent knowledge on all known classes of drug carriers, from microbes to man, it begins with a look at human and mammalian transporters. This is followed by microbial, fungal and parasitic transporters with special attention given to transport across those physiological barriers relevant for drug uptake, distribution and excretion.As a result, this key resource lays the foundations for understanding and investigating the molecular mechanisms for multidrug resistance in cancer cells, microbial resistance to antibiotics and pharmacokinetics in general. For anyone working with antibiotics and cancer chemotherapeutics, as well as being of prime interest to biochemists and biophysicists.

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