Dermatopathology

Description

This updated second edition provides a structured and highly illustrated guide to dermatopathology. It focuses on the most common dermatopathological diagnoses and presents their clinical, histological, and differential diagnostic features of the diseases. New chapters cover various inflammatory diseases such as interstitial granulomatous dermatitis and filler reactions as well as cutaneous neoplasms such as digital papillary adenocarcinoma. Dermatopathology aims to help readers to rapidly identify patterns and specific diagnostic features. The book is relevant to both practicing and trainee dermatologists and pathologists. Preface Contents Basic Principles 1 Principles of Diagnosis 2 Skin Biopsy 2.1 Biopsy Techniques 2.2 Fixation 2.3 Embedding and Sectioning 3 Histopathological Techniques 3.1 Staining 3.2 Immunohistochemical Stains 3.3 Immunofluorescence Studies 3.3.1 Direct Immunofluorescence 3.3.2 Indirect Immunofluorescence 3.3.3 Salt-Split Skin 3.4 Molecular Biological Procedures 3.4.1 In Situ Hybridization (ISH) 3.4.2 Fluorescence in Situ Hybridization (FISH) 3.4.3 Polymerase Chain Reaction (PCR) 4 Dermatopathologic Glossary Inflammatory and Infectious Dermatoses 5 Epidermis: Spongiosis, Acanthosis and Hyperparakeratosis 5.1 Dermatitis 5.2 Prurigo 5.3 Psoriasis 5.4 Pustular Psoriasis 5.5 Pityriasis Rosea 5.6 Cutaneous Fungal Infections 5.7 Human Papilloma Virus-Associated Acanthopapillomas: Verruca Vulgaris and Condyloma Acuminatum 5.8 Molluscum Contagiosum 5.9 Parapoxvirus Infections 6 Epidermis Acantholysis 6.1 Darier Disease 6.2 Hailey-Hailey Disease 6.3 Herpes Virus Infections 7 Bullous Diseases 7.1 Pemphigus Foliaceus 7.2 Pemphigus Vulgaris 7.3 Bullous Pemphigoid 7.4 Dermatitis Herpetiformis 7.5 Porphyria Cutanea Tarda 8 Interface Dermatoses 8.1 Erythema Multiforme 8.2 Pityriasis Lichenoides 8.3 Lichen Planus 8.4 Lichen Sclerosus 8.5 Lupus Erythematosus 8.6 Pigmented Purpuric Dermatoses 8.7 Incontinentia Pigmenti 9 Dermis Vascular Disorders 9.1 Leukocytoclastic Vasculitis 9.2 Granuloma Faciale and Erythema Elevatum et Diutinum 9.3 Polyarteritis Nodosa 9.4 Cryoglobulinemia 10 Dermis Granulomatous Inflammation 10.1 Granuloma Annulare 10.2 Necrobiosis Lipoidica 10.3 Interstitial Granulomatous Dermatitis 10.4 Sarcoidosis 10.5 Foreign Body Granuloma 10.6 Mycobacterial Infections 10.7 Syphilis 10.8 Leishmaniasis 11 Dermis Interstitial Inflammation 11.1 Borreliosis 11.2 Morphea 12 Dermis Diffuse Mixed Inflammatory Infiltrates 12.1 Urticaria 12.2 Acute Febrile Neutrophilic Dermatosis (Sweet Syndrome) 12.3 Eosinophilic Cellulitis (Wells Syndrome) 12.4 Arthropod Assault Reaction 13 Dermis - Degenerative and Metabolic Disorders 13.1 Chondrodermatitis Helicis Nodularis Chronica 13.2 Pseudoxanthoma Elasticum 13.3 Xanthoma 14 Dermis Inflammation of Adnexal Structures 14.1 Folliculitis 14.2 Alopecia Areata 14.3 Lupus Erythematosus of the Scalp 14.4 Folliculitis Decalvans 14.5 Lichen Ruber Planopilaris 15 Subcutaneous Fat - Panniculitis 15.1 Erythema Nodosum 15.2 Erythema Induratum and Nodular Vasculitis 15.3 Lupus Panniculitis 16 Drug Reactions 16.1 Specific Forms 16.2 Unspecific Forms 17 Artifactual Damage Cysts 18 Epithelial Cysts 18.1 Epidermoid Cyst 18.2 Trichilemmal Cyst 18.3 Steatocystoma 18.4 Apocrine Hidrocystoma 19 Pseudocysts 19.1 Digital Mucous Cyst Hamartomas and Neoplasms 20 Epidermal Hamartomas and Neoplasms 20.1 Epidermal Nevus 20.2 Nevus Sebaceus 20.3 Seborrheic Keratosis 20.4 Clear Cell Acanthoma 20.5 Porokeratosis 20.6 Actinic Keratosis 20.7 Bowen Disease 20.8 Squamous Cell Carcinoma 20.9 Keratoacanthoma 21 Melanocytic Lesions 21.1 Mucosal Melanotic Macule 21.2 Lentigo Simplex 21.3 Melanocytic Nevi–Junctional and Compound Types 21.4 Melanocytic Nevi–Dermal and Congenital Types 21.5 Halo Nevus 21.6 Blue Nevus 21.7 Dysplastic Melanocytic Nevus 21.8 Spitz Nevus 21.9 Desmoplastic Spitz Nevus 21.10 Pigmented Spindle Cell Nevus (Reed) 21.11 Clonal Nevus 21.12 Lentigo Maligna and Lentigo Maligna Melanoma 21.13 Superficial Spreading Melanoma 21.14 Nodular Melanoma 21.15 Acrolentiginous Melanoma 21.16 Desmoplastic Melanoma 21.17 Cutaneous Clear Cell Sarcoma 22 Adnexal Tumors 22.1 Sebaceous Hyperplasia 22.2 Sebaceous Adenoma 22.3 Pilomatricoma 22.4 Syringoma 22.5 Syringocystadenoma Papilliferum 22.6 Poroma 22.7 Hidradenoma Synonyms: Nodular Hidradenoma, Clear Cell Hidradenoma 22.8 Spiradenoma 22.9 Cylindroma 22.10 Paget Disease 22.11 Digital Papillary Adenocarcinoma 22.12 Trichoblastoma 22.13 Desmoplastic Trichoepithelioma 22.14 Basal Cell Carcinoma 22.15 Fibroepithelioma of Pinkus 22.16 Mixed Tumor of the Skin 23 Soft Tissue Proliferations and Neoplasms 23.1 Scar 23.2 Hypertrophic Scar and Keloid 23.3 Skin Tag Synonym: Fibroma Molle 23.4 Dermatofibroma 23.5 Dermatofibrosarcoma Protuberans 23.6 Atypical Fibroxanthoma 23.7 Leiomyoma 23.8 Nevus Lipomatosus Superficialis 23.9 Lipoma 23.10 Neurofibroma 23.11 Schwannoma Synonym: Neurilemmoma 23.12 Merkel Cell Carcinoma 24 Vascular Tumors 24.1 Hemangioma 24.2 Pyogenic Granuloma (Synonyme: Lobular Capillary Hemangioma) 24.3 Angiokeratoma 24.4 Kaposi Sarcoma 24.5 Angiosarcoma 25 Lymphomas and Pseudolymphomas 25.1 Mycosis Fungoides 25.2 Primary Cutaneous CD30-positive Lymphoproliferative Disorders 25.3 Primary Cutaneous Marginal Zone Lymphoma 25.4 Primary Cutaneous Follicle Center Lymphoma 25.5 Cutaneous Diffuse Large B-cell Lymphoma, Leg Type 25.6 Cutaneous B-cell Pseudolymphoma Syn.: Lymphocytoma Cutis, Lymphadenosis Cutis Benigna When Caused by Borrelial Infections 26 Histiocytoses and Mastocytoses 26.1 Langerhans Cell Histiocytoses 26.2 Juvenile Xanthogranuloma 26.3 Cutaneous Mastocytoses 27 Cutaneous Metastases Appendix_1 Appendix_2 Index