ENGLISH

Mri and trials of neurodegeneration in multiple sclerosis

By M. Filippi , M. Rovaris , G. Comi

Book information

Publisher
Springer
Year
2007
ISBN
9788847003903, 8847003903
Open Library ID
OL13430685M
Language
english
Format
PDF
Filesize
4 MB (3846030 bytes)
Series
Topics in neuroscience
Edition
1
Pages
233\233
Topic
Medicine Neurology
Library
Kingdwarf
Time added
2010-01-07 06:59:20

Description

In multiple sclerosis (MS), conventional magnetic resonance imaging (cMRI) has proved to be a valuable tool to increase diagnostic confidence and for monitoring the efficacy of experimental treatment. However, cMRI has limited specificity and accuracy of cMRI to the most disabling aspects of the MS pathology, known to occur in and outside macroscopic lesions. Modern quantitative MR techniques have the potential to overcome the limitations of cMRI, and their application is changing dramatically our understanding of how MS causes irreversible disability. In detail, there is an increasing body of MR evidence that MS is not only a white matter disease and does not only cause focal lesions, as well as that neurodegeneration is an important aspect of the disease (since the earliest clinical phases), which is only partially related to inflammatory changes. There is also increasing perception that modern MR methodologies should be more extensively employed in clinical trials to derive innovative information. Written by world-renowned scientists, the volume provides a state-of-the-art on the most recent MRI techniques related to MS, and it will bi and indispensable tool for all those working in this field.

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