ENGLISH

Current Topics in Microbiology and Immunology: Ergebnisse der Mikrobiologie und Immunitatsforschung

By H. Koprowski , P. K. Vogt , W. Kikuth , Erling Norrby (auth.) , W. Arber , W. Braun , F. Cramer , R. Haas , W. Henle , P. H. Hofschneider , N. K. Jerne , P. Koldowsky , O. Maaløe , R. Rott , H.-G. Schweiger , M. Sela , L. Syruček , E. Wecker (eds.)

Book information

Publisher
Springer-Verlag Berlin Heidelberg
Year
1968
ISBN
978-3-642-46120-0, 978-3-642-46118-7
DOI
10.1007/978-3-642-46118-7
Language
english
Format
PDF
Filesize
6 MB (6601972 bytes)
Series
Current Topics in Microbiology and Immunology 43
Edition
1
Pages
234\236
Orientation
yes
Scanned
yes
Time added
2013-08-01 04:00:00
general; Biomedicine generalgeneral; Life SciencesMedicine/Public Health

Description

Ever since arbovirus infections became known and their relative importance assessed, experiments were designed to elucidate the mode of transmission and the most important natural hosts responsible for perpetuating the infection in nature. Human infections and the disease in wild rodents, birds, and domestic animals were studied in relation to viremia and distribution of the infectious agent in the organism. With increasing epidemiological studies it became apparent that the neural manifestations of the disease are very uncommon, confined only to a small percentage of individuals of the most susceptible species. Various factors have been proposed to explain why in certain instances the virus becomes establish­ ed in the central nervous system and causes a serious or lethal disease. For example, differences in the virulence of the virus strains, varying susceptibility of individuals of one species, or intercurrent circumstances facilitating access of the virus to the central nervous system were alleged. Also, various possible routes of entry of the virus into the brain and spinal cord have been considered.

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