Prostate Cancer: Biology, Genetics, and the New Therapeutics

Description

Front Matter....Pages i-xviii Front Matter....Pages 1-1 Building the Road to Defeat Prostate Cancer....Pages 3-10 Front Matter....Pages 11-11 Hereditary Prostate Cancer....Pages 13-28 AR Gene Alterations in Prostate Cancer Progression....Pages 29-37 Lethal Metastatic Human Prostate Cancer....Pages 39-60 Tumor Suppressor Genes in Prostate Cancer....Pages 61-94 Androgen Receptor Polymorphisms and Prostate Cancer Risk....Pages 95-109 The Genetic Epidemiology of Prostate Cancer....Pages 111-121 Determination of Gene and Chromosome Dosage in Prostatic Intraepithelial Neoplasia and Prostatic Carcinoma by Molecular Cytogenetic Techniques....Pages 123-140 Genetic Alterations in Prostatic Intraepithelial Neoplasia (PIN)....Pages 141-161 Xenograft Models and the Molecular Biology of Human Prostate Cancer....Pages 163-174 Comprehensive Analyses of Prostate Gene Expression....Pages 175-189 Front Matter....Pages 191-191 The Role of the Nuclear Matrix and Cytoskeleton in Cancer....Pages 193-206 The Role of Cell Adhesion Molecules in Prostate Development and Carcinogenesis....Pages 207-218 Ligand Dependent and Independent Activation of the Androgen Receptor....Pages 219-239 Tyrosine Kinases and Cellular Signaling in Prostate Cancer....Pages 241-266 Molecular Pathways Underlying Prostate Cancer Progression....Pages 267-277 Angiogenesis and Prostate Cancer....Pages 279-306 Prostate Specific Membrane Antigen....Pages 307-326 Targeting Antiapoptotic Genes Upregulated by Androgen Withdrawal Using Antisense Oligodeoxynucleotides to Enhance Androgen-and Chemo-Sensitivity in Prostate Cancer....Pages 327-340 Stromal-Epithelial Interaction....Pages 341-362 Front Matter....Pages 363-363 Chemoprevention of Prostate Cancer....Pages 365-375 Anatomic Radical Retropubic Prostatectomy for Prostate Cancer....Pages 377-386 Radiation Therapy as Applied to Prostate Cancer....Pages 387-413 Prostate Cancer Chemotherapy....Pages 415-431 The Role of Small Bioactive Peptides and Cell Surface Peptidases in Androgen Independent Prostate Cancer....Pages 433-447 Development of Dendritic Cell-Based Prostate Cancer Vaccine....Pages 449-459 Antiprogression Agents for Prostate Cancer....Pages 461-481 Human Gene Therapy for Urological Oncology....Pages 483-497 Chemoprevention Trials for Prostate Cancer....Pages 499-518 Back Matter....Pages 519-531