Alternatives to Animal Testing: Proceedings of Asian Congress 2016

Description

This open access book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments – replacement, reduction, and refinement, collectively known as the 3Rs. Important examples from across the world of implementation of the 3Rs in the testing of cosmetics, chemicals, pesticides, and biologics, including vaccines, are described, with additional information on relevant regulations. The coverage also encompasses emerging approaches to alternative tests and the 3Rs. The book is based on the most informative contributions delivered at the Asian Congress 2016 on Alternatives and Animal Use in the Life Sciences. It will be of value for those working in R&D, for graduate students, and for educators in various fields, including the pharmaceutical and cosmetic sciences, pharmacology, toxicology, and animal welfare. The free, open access distribution of Alternatives to Animal Testing is enabled by the Creative Commons Attribution license in International version 4: CC BY 4.0. Front Matter ....Pages i-vi Zebrafish, Danio Rerio as a Replacement Alternative Model Useful in CKDu Experiments (Mangala Gunatilake)....Pages 1-7 Testing Method Development and Validation for in Vitro Skin Irritation Testing (SIT) by Using Reconstructed Human Epidermis (RhE) Skin Equivalent - EPiTRI® (Yu-Chun Lin, Hui-Chun Hsu, Chiu-Hsing Lin, Cheng-Yi Wu, Wannhsin Chen, Huey-Min Lai)....Pages 8-19 Development the Technique for the Preparation and Characterization of Reconstructed Human Epidermis (RHE) (Herlina B. Setijanti, Eka Rusmawati, Rahmi Fitria, Tuty Erlina, Rina Adriany, Murtiningsih)....Pages 20-32 Alternative Research (3Rs) in the World, Asia and Japan (Tsutomu Miki Kurosawa)....Pages 33-36 Approaches to Reducing Animal Use for Acute Toxicity Testing: Retrospective Analyses of Pesticide Data (Judy Strickland, Michael W. Paris, David Allen, Warren Casey)....Pages 37-49 Progress in Eliminating One-Year Dog Studies for the Safety Assessment of Pesticides (Horst Spielmann)....Pages 50-56 Cosmetic Regulation and Alternatives to Animal Experimentation in India (Mohammad A. Akbarsha, Benedict Mascarenhas)....Pages 57-62 Guidance on the Use of Alternative Test Methods for the Safety Assessment of Cosmetics and Quasi-drugs (Hajime Kojima, Yoshiaki Ikarashi, Tokio Nakada, Akiko Yagami, Kenji Sugibayashi, Hiroaki Todo et al.)....Pages 63-68 Alternatives and Refinement for Animal Experimentation in Cancer Research (Arvind D. Ingle)....Pages 69-75 3Rs in Quality Control of Human Vaccines: Opportunities and Barriers (Sylvie Uhlrich, Emmanuelle Coppens, Frederic Moysan, Sue Nelson, Nolwenn Nougarede)....Pages 76-82 The Use of Adverse Outcome Pathways (AOPs) to Support Chemical Safety Decisions Within the Context of Integrated Approaches to Testing and Assessment (IATA) (Catherine Willett)....Pages 83-90 Mechanism-Based Evaluation System for Hepato- and Nephrotoxicity or Carcinogenicity Using Omics Technology (Fumiyo Saito)....Pages 91-104 Alternative Methods for Developmental Toxicity Testing Using Mouse ESCs (Hee Young Kang, Eui-Bae Jeung)....Pages 105-109 Futuristic Approach to Alternative Model Organisms: Hydra Stakes Its Claim (Anbazhagan Murugadas, Mohammed Zeeshan, Mohammad A. Akbarsha)....Pages 110-123 The Lush Prize and Young Researcher Asia Awards 2016 (Rebecca Ram)....Pages 124-128 Back Matter ....Pages 129-130