ENGLISH

Design and Optimization in Organic Synthesis

Book information

Publisher
Elsevier Science
Year
1992
ISBN
044489201X, 9780444892010, 9780080868356
ISSN
0922-3487
LCC
QD262 .C32 1992
Open Library ID
OL1556305M
Language
english
Format
PDF
Filesize
7 MB (7071910 bytes)
Series
Data Handling in Science and Technology 8
Edition
3
Pages
ii-v, 1-536\553
Library
Kingdwarf
Time added
2010-01-07 06:59:20

Description

This is the first general textbook on experimental design and optimization in organic synthesis. The book presents a unified methodology for carrying out systematic studies when the objective is to develop efficient and optimum synthetic methods. Strategies are included both for exploring the experimental conditions and for systematic studies of entire reaction systems (substrates, reagent(s) and solvents). The methodology is based on multivariate statistical techniques. The following topics are treated in depth: classical two-level designs for screening experiments, gradient methods (steepest ascent, simplex methods) as well as response surface techniques for optimization, principal components analysis and PLS modelling. The book is intended as a hands-on text for chemists and engineers engaged in developing synthetic methods in industrial research, e.g. in fine chemicals and pharmaceuticals production, as well as for advanced undergraduate students, graduate students, and researchers in an academic environment.

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