Drug-Induced Lung Injury

Description

This book covers various aspects of a respiratory system disorder associated with prescribed drugs that do not yet have established treatment guidelines, and for which the only treatment is to discontinue taking the drug. Very little clinical evidence regarding the disorder is available, since randomized trials cannot to be carried out, the onset of the disorder cannot be predicted, and the resulting pathological condition is life-threatening. However, the need for an established treatment continues to grow due to the introduction of many new drugs, such as anti-neoplastic drugs, biological products, and molecular target drugs, the adverse effects of which are difficult to differentiate from those of other lung diseases, such as lung infectious diseases. Drug-Induced Lung Injury offers a highly beneficial resource not only for respiratory physicians but also all medical clinicians who prescribe drugs, nurses, pharmacists and pharmaceutical scientists. Written by pioneering experts in the field, the book examines a wealth of cases and the insights they yield concerning the diagnosis, treatment and specific drugs causing the disease. It not only fosters a deeper understanding of the disorder but also highlights the current challenges and paves the way for future clinical research. Front Matter ....Pages i-viii Front Matter ....Pages 1-1 Definition and Pathogenesis of Drug-Induced Lung Injury: What Is DLI? (Hidetoshi Nakamura, Minoru Kanazawa)....Pages 3-12 Epidemiology and Risk Factors of Drug-Induced Lung Disease: What Are the Prevalence and Risk Factors of DILD? (Tomohiro Handa, Atsushi Yonezawa, Arata Azuma)....Pages 13-26 Clinical Characteristics of DLI: What Are the Clinical Features of DLI? (Atsuhito Ushiki, Masayuki Hanaoka)....Pages 27-33 Front Matter ....Pages 35-35 Diagnostic Approach for DLI: How is DLI Diagnosed? (Shu Hashimoto, Mari Hikichi, Mai Takahashi, Yasuhiro Gon)....Pages 37-44 Blood Tests for the Diagnosis and/or Management of DLI: What Are the Clinical Significances of KL-6, SP-A, SP-D, and DLST in DLI? (Yasushi Horimasu, Noboru Hattori)....Pages 45-57 Imaging Features of Drug-Induced Interstitial Lung Disease: How HRCT of DLI Is Interpreted (Fumikazu Sakai)....Pages 59-81 Pathology of DLI: What Is the Pathological Significance of DLI? (Yasuhiro Terasaki, Yuh Fukuda)....Pages 83-101 Differential Diagnoses of DLI: What Are the Differential Diagnoses of DLI? (Akihito Yokoyama)....Pages 103-112 Front Matter ....Pages 113-113 Therapeutic Strategies for DLI: How Should DLI Be Treated? (Sakae Homma)....Pages 115-125 Front Matter ....Pages 127-127 DLI Induced by Nonmolecular Target Antineoplastic Drugs: What Are the Characteristics of DLI in Nonmolecular Target Antineoplastic Drugs? (Yasuo Saijo)....Pages 129-138 DLI Induced by Molecular Target Antineoplastic Drug: What Are the Characteristics of DLI in Molecular Target Antineoplastic Drugs? (Nobuyuki Koyama)....Pages 139-164 DLI Caused by Disease-Modifying Antirheumatic Drugs: What Are the Characteristics of DLI by Disease-Modifying Antirheumatic Drugs? (Hideto Kameda)....Pages 165-176 DLI Induced by Herbal Medicine: What Are the Characteristics of DLI due to Herbal Medicines? (Mitsuhiro Abe, Kenji Tsushima, Koichiro Tatsumi)....Pages 177-199 DLI Induced by Antiarrhythmic Drug and Antimicrobial Drug: What Are the Characteristics of DLI in Antiarrhythmic Drugs and Antimicrobial Drugs? (Fumio Sakamaki)....Pages 201-215