Gene Delivery Systems: Development and Applications

Description

This unique volume in our Drugs and Pharmaceutical Sciences series covers the development of gene therapy today, the technology involved, clinical applications of siRNA, non-viral vector-based mRNA delivery using nanotechnology, and RNA based vaccines for treating the infectious diseases. It also presents the current application of the CRISPR/Cas9 gene-editing technique which has revolutionized genome editing and which was awarded the 2020 Nobel Prize in Chemistry. Several new drug delivery systems are explored for the applications of gene therapy. These are found to be useful in treating chronic illnesses, including cancer and infectious diseases. Key Features: Overview of the development of gene therapy Provides the most up to date information on the development of gene therapy, from the technology involved to gene correction and genome editing Presents CRISPR gene therapy recent trends and applications Discusses siRNA, mRNA, and DNA plasmids Cover Half Title Series Title Copyright Dedication Contents Preface About the Editor List of Contributors Chapter 1 Overview of Development of Gene Therapy Chapter 2 Understanding the Technologies Involved in Gene Therapy Chapter 3 Gene Therapy and Gene Correction: Target, Progress and Challenges to Treat Human Diseases Chapter 4 Clinical Applications of siRNA Chapter 5 Human Genomics Projects, Gene Therapy and Precision Medicine Chapter 6 The Current State of Non­Viral Vector–Based mRNA Medicine Using Various Nanotechnology Applications Chapter 7 RNA­Based Vaccines for Infectious Disease Chapter 8 Conditional Replication of Oncolytic Virus Based on Detection of Oncogenic mRNA Chapter 9 Unilateral Ex Vivo Gene Therapy by GDNF in Neurodegenerative Diseases Chapter 10 Gene Therapy for Cancer Treatment: Recent Trends and Clinical Evidence Chapter 11 Gene Therapy for Retina and Eye Diseases Chapter 12 COVID­19 Vaccine Development and Applications Chapter 13 In Vivo Gene Therapy: AAV2 Vectors Chapter 14 Gene Therapy for Acquired Tissue Damage: Scope, Quality, Non­Clinical and Clinical Guidelines of Gene Therapy Medical Products Chapter 15 iMRI for Clinical Gene Therapy Index