Molecular Imprinting for Nanosensors and Other Sensing Applications

Description

Molecular Imprinting for Nanosensors and Other Sensing Applications provides fundamental knowledge on molecular imprinting, including types, preparation methods, properties and characterization techniques. The book also covers the state-of-the-art technological developments of sensors that incorporate with microfluidic systems, lab-on-a-chip-tools, and other techniques. Sections discuss the integration of molecularly imprinted polymers with current top-notch tools and platforms that facilitate their potential applications in the realms of medicine, pharmaceuticals and environmental monitoring. Topics of note include molecularly imprinted polymer-based sensor models, their functionalization methodologies, prominent characteristics, and their characterization tools. Front matter Copyright Contributors About the author Preface Chapter 1 - Fundamentals and Applications of Molecularly Imprinted Systems 1 - Introduction 2 - Fundamentals of molecular imprinting method 3 - Preparation methods of molecularly imprinted polymers 3.1 - Bulk imprinting 3.2 - Surface imprinting 3.3 - Epitope imprinting 3.4 - Micro-contact imprinting 4 - Applications of molecularly imprinted polymers-based systems 4.1 - Sensor systems 4.2 - Chromatography systems 4.3 - Microfluidic systems 4.4 - Computational modeling systems 5 - Prospects for the future References Chapter 2 - Molecular Imprinting-Based Smart Nanosensors for Pharmaceutical Applications 1 - Introduction 2 - Molecular imprinting-based sensor systems toward pharmaceuticals 2.1 - Molecular imprinting-based spectroscopic sensor systems 2.2 - Molecular imprinting-based electrochemical sensor systems 2.3 - Molecular imprinting-based piezoelectric sensor systems 3 - Conclusions References Chapter 3 - Tracking and Treating: Molecularly Imprinted Polymer-Based Nanoprobes Application in Theranostics 1 - Introduction 2 - Manufacturing of MIP-NPs 2.1 - Precipitation polymerization 2.2 - Emulsion polymerization 2.3 - Iniferter polymerization 2.4 - Core–shell NPs 3 - Probing applications of MIPs 3.1 - Artificial antibodies 3.2 - Application in cells and in vivo 3.3 - Drug delivery 3.4 - Cell adhesion and behavior modulation 3.5 - Targeted cell imaging 4 - Immunoassay-like application of MIPs 5 - Challenges and perspectives 6 - Conclusion References Chapter 4 - Molecular Imprinted Sensors for Ion-Sensing 1 - Introduction 1.1 - Ion-sensing 1.2 - Molecular imprinting technology 1.3 - Principle and technology of sensors 1.3.1 - Electrochemical sensors 1.3.2 - Optical sensors 1.3.3 - Piezoelectric sensors 1.3.4 - Colorimetric sensors 1.4 - Applications of MIP’s ion sensors 1.4.1 - Detection of copper ions 1.4.2 - Detection cadmium and lead ions 1.4.3 - Detection of mercury ions 1.4.4 - Detection of other ions 2 - Conclusions and prospects References Chapter 5 - Molecularly Imprinted Polymer-Based Optical Sensors for Pesticide Determination 1 - Introduction—molecularly imprinted polymers 2 - Basic principles of optical sensing systems 2.1 - Ultraviolet (UV)-visible absorption 2.2 - Luminescence (fluorescence, phosphorescence, chemiluminescence) 2.3 - Surface plasmon resonance (SPR) 2.4 - Surface-enhanced Raman scattering (SERS) 3 - Application of MIP-based optical sensors for determination of pesticides 3.1 - MIP-based UV-Vis spectrophotometric sensors 3.2 - MIP-based fluorimetric sensors 3.3 - MIP-based phosphorimetric sensors 3.4 - MIP-based chemiluminescent sensors 3.5 - MIP-based surface plasmon resonance sensors 3.6 - MIP-based surface-enhanced Raman scattering sensors 4 - Conclusion References Chapter 6 - Immunosensors Based on the Technology of Molecular Imprinted Polymers 1 - Introduction 2 - Applications of MIP-based biosensors 2.1 - MIPs for biomarkers detection 2.2 - MIPs for hormones detection 2.3 - MIPs for other biological molecules detection 2.4 - MIPs for drugs detection 2.5 - MIPs for pesticides detection 2.6 - MIPs for toxins detection 2.7 - MIPs for other analytes detection 3 - Conclusion References Chapter 7 - Nanobiosensors: Usability of Imprinted Nanopolymers 1 - Introduction 2 - Types of nanomaterials 2.1 - Carbon nanomaterials 2.2 - Inorganic nanomaterials 2.3 - Organic nanomaterials 2.4 - Composite nanomaterials 3 - What are the interactions between biosensors and nanomaterials? 3.1 - Nanomaterials in biosensing devices 3.1.1 - Carbon nanotubes (CNTs) 3.1.2 - Graphene 3.1.3 - Carbon quantum dots (CQDs) 3.1.4 - Nanoparticles (NPs) 3.1.5 - As a natural nanomaterial: chitosan 3.1.6 - Here are the stars: dendrimers 3.1.7 - Biological and other NMs 4 - Molecular imprinted polymers (MIPs) 4.1 - Molecular imprinted polymers in biosensors 4.1.1 - How do MIPs mimic biological systems? 4.1.2 - Cell recognition with MIP 4.1.3 - Biosensing and molecular imprinting combination 5 - Imprinted nanopolymers (NANO-MIPs) and sensor types 5.1 - Electrochemical sensors 5.1.1 - Noble nanomaterials 5.1.1.1 - Gold nanoparticles 5.1.1.2 - Silver nanoparticles 5.1.1.3 - Platinum nanoparticles 5.1.1.4 - Palladium nanoparticles 5.1.1.5 - Metal oxide nanomaterials 5.1.1.6 - Carbon nanomaterials 5.1.1.7 - Polymeric nanomaterials 5.1.1.7.1 - Molecularly imprinted polymers 5.2 - Optical sensors 5.3 - Surface plasmon resonance (SPR) 5.4 - Surface-enhanced Raman scattering (SERS) 5.5 - Piezoelectric sensors 6 - Future trends on imprinted nanopolymers (NANO-MIPs) 6.1 - Paper-based analytical devices 6.2 - Wearable sensors 6.3 - Medical applications 6.4 - Environmental and food safety applications 6.5 - Tattoo applications Acknowledgements References Chapter 8 - Molecularly Imprinted Electrochemical Sensors and Their Applications 1 - Introduction 2 - Molecularly imprinted electrochemical sensors 3 - Sensor applications of molecularly imprinted electrochemical sensors 3.1 - Molecularly imprinted electrochemical sensors for proteins 3.2 - Molecularly imprinted electrochemical sensors for hormones 3.3 - Molecularly imprinted electrochemical sensors for pharmaceuticals 3.4 - Molecularly imprinted electrochemical sensors for neurotransmitters 3.5 - Molecularly imprinted electrochemical sensors for pesticides 4 - Conclusion References Chapter 9 - Quantum Dots Coated with Molecularly Imprinted Polymer as Probes for Environmentally and Medicinally Important ... 1 - Introduction 1.1 - Quantum dots (QDs) 1.2 - Molecular imprinting 2 - Synthetic approaches for QDs coated with MIPs 3 - Applications 3.1 - Determination of medicinally important analytes 3.2 - Determination of environmentally important analytes 4 - Conclusion References Chapter 10 - Molecular Imprinting-Based Sensing Platforms for Recognition of Microorganisms 1 - Introduction 2 - Molecular imprinting 3 - Imprinting of microorganisms 4 - Sensing platforms 5 - Applications 6 - Concluding remarks and future perspectives References Chapter 11 - Applications of Molecularly Imprinted Polymers/Fluorescence-Based (Nano)Sensors 1 - Introduction 2 - Organic fluorescent dyes 3 - Semiconductor quantum dots 4 - Fluorescent carbon nanoparticles 5 - Fluorescent rare earth metals 6 - Conclusions and future perspectives Acknowledgments References Chapter 12 - Molecularly Imprinted Based Sensors for Detection of Allergens 1 - Introduction 2 - Immunoglobulin E 2.1 - Hypersensitivity 3 - Molecularly imprinted polymer-based sensors 4 - Biosensors 4.1 - Mass sensitive-based sensor for selective allergen detection 4.2 - Optical-based sensor for selective allergen detection 4.3 - Electrochemical-based sensor for selective allergen detection 4.4 - Nanomaterials-based allergen sensor 5 - Future prospects References Chapter 13 - Molecular Imprinted Polymers for Mass Sensitive Sensors: Comparation of Performance Toward Immuno-Sensing Stra... 1 - Introduction 1.1 - Concept of molecular imprinting technology 1.1.1 - Functional monomer selection and template molecule integration 1.1.2 - Polymerization 1.1.3 - Template removal 1.1.4 - Rebinding 1.2 - Preparation techniques of molecular imprinted polymers 1.2.1 - Noncovalent imprinting (self-assembly approach) 1.2.2 - Covalent imprinting (pre-organized approach) 1.2.3 - Semi-covalent imprinting 1.3 - Selectivity characteristics of imprinted polymers 1.4 - Physical forms of molecular imprinted polymers 1.4.1 - Monoliths 1.4.2 - Thin films 1.4.3 - Membranes 1.4.4 - Beads 1.5 - Micro- and nanostructures of molecular imprinted polymers 2 - Molecular imprinted polymers as bio-recognition elements in mass sensitive immunosensors 2.1 - Quartz crystal microbalance (QCM) 2.2 - Bulk acoustic wave (BAW) devices 2.3 - Surface acoustic wave (SAW) devices 3 - MIPs immobilization strategies onto internal surfaces of the transducers 4 - Exemplary detection applications of MIPs-based mass sensitive immunosensors (from cells to viruses) 5 - Nanosized molecular imprinted polymers for mass sensitive sensor applications 6 - Critical comparison between MIPs and traditional biological recognition elements toward immuno-sensing approaches 7 - Concluding remarks References Chapter 14 - Template Removal in Molecular Imprinting: Principles, Strategies, and Challenges 1 - Introduction 2 - Soxhlet extraction 3 - Solvent extraction 3.1 - Physically assisted solvent extraction 3.1.1 - Microwave-assisted extraction 3.1.2 - Ultrasound-assisted extraction 3.1.3 - Accelerated solvent extraction 3.2 - Supercritical fluid extraction 4 - Chemical cleavage 5 - Solid-phase imprinting 6 - Conclusions and future outlook Acknowledgments References Index