Zinc Signaling

Description

This book, now in an extensively revised second edition, describes the crucial role of zinc signaling in biological processes on a molecular and physiological basis. Global leaders in the field review the latest knowledge, including the very significant advances in understanding that have been achieved since publication of the first edition. Detailed information is provided on all the essentials of zinc signaling, covering molecular aspects and the roles of zinc transporters, the zinc sensing receptor, and metallothioneins. Detection techniques for zinc signals, involving genetically encoded and chemical probes, are also described. The critical contributions of the zinc signal in maintaining health and the adverse consequences of any imbalance in the signal are then thoroughly addressed. Here, readers will find up-to-date information on the significance of the zinc signal in a wide range of conditions, including cardiovascular disorders, neurodegenerative diseases, diabetes, autoimmune diseases, inflammatory conditions, skin disease, osteoarthritis, and cancer. The book will be of value for researchers, clinicians, and advanced students. Front Matter ....Pages i-viii Opening the Second Era of Zinc Signaling Study (Toshiyuki Fukada)....Pages 1-4 Regulation of Cellular Zinc Ions and Their Signaling Functions (Wolfgang Maret)....Pages 5-22 Zinc Transporter Proteins: A Review and a New View from Biochemistry (Taiho Kambe, Eisuke Suzuki, Taiki Komori)....Pages 23-56 The Metallothionein-Zinc Landscape: How It Shapes Antimicrobial Immunity (Debabrata Chowdhury, George S. Deepe Jr, Kavitha Subramanian Vignesh)....Pages 57-77 Role of Zinc Signaling in Mast Cell, Basophil, T Cell, and B Cell (Keigo Nishida, Michiko Kato, Ryota Uchida)....Pages 79-97 Review: The Role of Zinc Signaling in Reproduction (Atsuko Kageyama, Takafumi Namiki, Junya Ito, Naomi Kashiwazaki)....Pages 99-121 Zinc Signaling in Skeletal Muscle (Kristyn Gumpper, Jianjie Ma)....Pages 123-137 Zinc Signaling in Aging Heart Function (Belma Turan, Deniz Billur, Yusuf Olgar)....Pages 139-164 Zinc Signaling in the Life and Death of Neurons (Elias Aizenman)....Pages 165-185 Possible Therapeutic Roles of Metallothionein-3 and Zinc in Endosome-Autophagosome-Lysosome Pathway (EALP) Dysfunction in Astrocytes (Ha Na Kim, Bo-Ra Seo, Sook-Jeong Lee, Jae-Young Koh)....Pages 187-200 Zinc in Neurodegeneration (Stuart D. Portbury, Ashley I. Bush, Paul A. Adlard)....Pages 201-228 Role of Zinc Transporters in Type 2 Diabetes and Obesity (Ayako Fukunaka, Yoshio Fujitani)....Pages 229-242 Zinc Signals in Immunology (Martina Maywald, Lothar Rink)....Pages 243-277 Zinc Signals in Inflammation (Sannette C. Hall, Daren L. Knoell)....Pages 279-304 Zinc Transporters and Zinc Signaling in Skin Formation and Diseases (Bum-Ho Bin, Mi-Gi Lee, Takafumi Hara, Teruhisa Takagishi, Toshiyuki Fukada)....Pages 305-317 Post-translational Mechanisms of Zinc Signalling in Cancer (Thirayost Nimmanon, Kathryn M. Taylor)....Pages 319-345 Zinc Signaling (Zinc’ing) in Intestinal Function (Michal Hershfinkel, Johnny Iv, Shannon L. Kelleher)....Pages 347-363 In Situ Imaging of Zinc with Synthetic Fluorescent Probes (Jiyao Yu, Christoph J. Fahrni)....Pages 365-388 Zinc Signals in Biology (Hak Chung, Amanda J. Bird)....Pages 389-410 Back Matter ....Pages 411-413