ENGLISH

Biosynthesis: Aromatic Polyketides, Isoprenoids, Alkaloids

By Ben Shen (auth.) , Dr. Finian J. Leeper , Prof. Dr. John C. Vederas (eds.)

Book information

Publisher
Springer-Verlag Berlin Heidelberg
Year
2000
ISBN
978-3-540-66573-1, 978-3-540-48146-1
DOI
10.1007/3-540-48146-X
Language
english
Format
PDF
Filesize
3 MB (2717285 bytes)
Series
Topics in Current Chemistry 209
Edition
1
Pages
247\254
Orientation
yes
Scanned
yes
Time added
2013-08-01 04:00:00
generalOrganic Chemistry; Biochemistry

Description

This book is the second of two volumes that deal with discovery of chemical pathways of biosynthesis of natural products (secondary metabolites). Volume 1 covered the use of isotopes in biosynthetic research and the formation of enzyme cofactors and reduced polyketides. This second volume describes biosynthesis of aromatic (unreduced) polyketides, enzymes responsible for cyclization of terpenoids (isoprenoids), and biochemical generation of selected classes of alkaloids (prenylated tryptophan, tropane, pyrrolizidine). Knowledge of the pathways and the techniques to elucidate them opens the door to combinatorial biosynthesis as well as to the production of targeted pharmaceutical agents utilizing a combination of chemistry, molecular biology and protein biochemistry.

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