Биоорганическая химия

Description

Содержит методические рекомендации для подготовки к лабораторным занятиям по биоорганической химии на английском языке. К каждой теме даны цель занятия, вопросы для обсуждения, письменные задания, а также указана литература для подготовки. Приведены описания и протоколы лабораторных опытов. Предназначен для студентов 1-го курса медицинского факультета иностранных учащихся, обучающихся на английском языке по специальности «Лечебное дело». МИНИСТЕРСТВО ЗДРАВООХРАНЕНИЯ РЕСПУБЛИКИ БЕЛАРУСЬ БИООРГАНИЧЕСКАЯ ХИМИЯ Минск БГМУ 2019 Recommended literature: 1. Zurabyan, S. E. Fundamentals of Bioorganic Chemistry / S. E. Zurabyan. 2006. P. 19–32. 2. Zurabyan, S. E. Fundamentals of Bioorganic Chemistry / S. E. Zurabyan. 2012. P. 27–39. 3. Ryneiskaya, O. N. Bioorganic chemistry. Course of lecture / O. N. Ryneiskaya, I. V. Rama-nouski. 2015. P. 3–7. Exercises: Recommended literature: 1. Zurabyan, S. E. Fundamentals of Bioorganic Chemistry / S. E. Zurabyan. 2006. P. 5–17, 33–44. 2. Zurabyan, S. E. Fundamentals of Bioorganic Chemistry / S. E. Zurabyan. 2012. P. 13–25, 40–49. 3. Ryneiskaya, O. N. Bioorganic chemistry. Course of lecture / O. N. Ryneiskaya, I. V. Rama-nouski. 2015. P. 7–16. Exercises: 1. Zurabyan, S. E. Fundamentals of Bioorganic Chemistry / S. E. Zurabyan. 2006. P. 61–81. 2. Zurabyan, S. E. Fundamentals of Bioorganic Chemistry / S. E. Zurabyan. 2012. P. 76–81, 149–161. 3. Ryneiskaya, O. N. Bioorganic chemistry. Course of lecture / O. N. Ryneiskaya, I. V. Rama-nouski. 2015. P. 16–27. Recommended literature: 1. Zurabyan, S. E. Fundamentals of Bioorganic Chemistry / S. E. Zurabyan. 2006. P. 94–110. 2. Zurabyan, S. E. Fundamentals of Bioorganic Chemistry / S. E. Zurabyan. 2012. P. 52–57, 75, 82–96. 3. Ryneiskaya, O. N. Bioorganic chemistry. Course of lecture / O. N. Ryneiskaya, I. V. Rama-nouski. 2015. P. 27–28, 30–35. Problems for discussion: Exercises: 10. Indicate compound possessing strongest reaction ability in the SE mechanism: 1) benzene; 2) toluene; 3) benzoic acid; 4) pyridine. Accomplishment: to 4 drops of bromine water*0F add 2 drops of α-pinene* and shake. Observed changes: _______________________________________________________________ Observed changes: _______________________________________________________________ Recommended literature: 1. Zurabyan, S. E. Fundamentals of Bioorganic Chemistry / S. E. Zurabyan. 2006. P. 47–59, 112–131. 3. Ryneiskaya, O. N. Bioorganic chemistry. Course of lecture / O. N. Ryneiskaya, I. V. Rama-nouski. 2015. P. 28–30, 35–41. Exercises: Observed changes: _______________________________________________________________ 1. Zurabyan, S. E. Fundamentals of Bioorganic Chemistry / S. E. Zurabyan. 2006. P. 133–147. 2. Zurabyan, S. E. Fundamentals of Bioorganic Chemistry / S. E. Zurabyan. 2012. P. 121–133. 3. Ryneiskaya, O. N. Bioorganic chemistry. Course of lecture / O. N. Ryneiskaya, I. V. Rama-nouski. 2015. P. 28–30, 35–41. Recommended literature: 3. Ryneiskaya, O. N. Bioorganic chemistry. Course of lecture / O. N. Ryneiskaya, I. V. Rama-nouski. 2015. P. 47–52. Problems for discussion: Exercises: Recommended literature: study the literature from the theme № 1 to № 7. Questions to the concluding test: Recommended literature: 3. Ryneiskaya, O. N. Bioorganic chemistry. Course of lecture / O. N. Ryneiskaya, I. V. Rama-nouski. 2015. P. 52–61. Problems for discussion: Exercises: 3. Ryneiskaya, O. N. Bioorganic chemistry. Course of lecture / O. N. Ryneiskaya, I. V. Rama-nouski. 2015. P. 61–69. Recommended literature: 3. Ryneiskaya, O. N. Bioorganic chemistry. Course of lecture / O. N. Ryneiskaya, I. V. Rama-nouski. 2015. P. 76–85. Problems for discussion: Exercises: Recommended literature: 1. Zurabyan, S. E. Fundamentals of Bioorganic Chemistry / S. E. Zurabyan. 2006. P. 199–208. 2. Zurabyan, S. E. Fundamentals of Bioorganic Chemistry / S. E. Zurabyan. 2012. P. 207–216. 3. Ryneiskaya, O. N. Bioorganic chemistry. Course of lecture / O. N. Ryneiskaya, I. V. Rama-nouski. 2015. P. 85–91. Exercises: Recommended literature: 3. Ryneiskaya, O. N. Bioorganic chemistry. Course of lecture / O. N. Ryneiskaya, I. V. Rama-nouski. 2015. P. 92–98. Problems for discussion: Exercises: 1. Write down proteinogenic amino acids at the mentioned below table with three letter code. 2. Write down the formulas of aliphatic amino acids, designate chiral centers. 3. Write Fischer projection of L-valine. 4. Write down the formulas of aromatic amino acids. 5. Write the structures of hydroxyl containing amino acids. 6. Write the structures of S-containing amino acids. 7. Write down the hydrophilic amino acids with negative ionized radical. 8. Write down the hydrophilic AA with positive ionized radical. 9. Write down the tryptophan formula. Indicate heterocycle in this AA. 10. Write down the hydrophilic AA containing amide group. 11. Complete the scheme: 12. Write down the formula of proline and fill in the scheme. Indicate the coenzyme of this reaction. 13. Write the reaction of transamination between L-alanine and α oxoglutaric acid. Indicate the coenzyme of this reaction. 14. Write the scheme of oxidative deamination reaction of Glu in vivo. Recommended literature: 1. Zurabyan, S. E. Fundamentals of Bioorganic Chemistry / S. E. Zurabyan. 2006. P. 211–224. 2. Zurabyan, S. E. Fundamentals of Bioorganic Chemistry / S. E. Zurabyan. 2012. P. 224–228. 3. Ryneiskaya, O. N. Bioorganic chemistry. Course of lecture / O. N. Ryneiskaya, I. V. Rama-nouski. 2015. P. 99–103. Exercises: It is the example of inreversible protein precipitation. Proteins can not be soluble in the same solvent. Inreversible reactions are protein precipitation reactions with heavy metals, mineral (inorganic) and organic acids, alkaloid reagents and when b... Recommended literature: 1. Zurabyan, S. E. Fundamentals of Bioorganic Chemistry / S. E. Zurabyan. 2006. P. 225–237. 2. Zurabyan, S. E. Fundamentals of Bioorganic Chemistry / S. E. Zurabyan. 2012. P. 246–256. 3. Ryneiskaya, O. N. Bioorganic chemistry. Course of lecture / O. N. Ryneiskaya, I. V. Rama-nouski. 2015. P. 103–108. Problems for discussion: Exercises: Recommended literature: 1. Zurabyan, S. E. Fundamentals of Bioorganic Chemistry / S. E. Zurabyan. 2006. P. 238–247. 2. Zurabyan, S. E. Fundamentals of Bioorganic Chemistry / S. E. Zurabyan. 2012. P. 173–182. 3. Ryneiskaya, O. N. Bioorganic chemistry. Course of lecture / O. N. Ryneiskaya, I. V. Rama-nouski. 2015. P. 108–116. Problems for discussion: Exercises: 1. Zurabyan, S. E. Fundamentals of Bioorganic Chemistry / S. E. Zurabyan. 2006. P. 251–258. 3. Ryneiskaya, O. N. Bioorganic chemistry. Course of lecture / O. N. Ryneiskaya, I. V. Rama-nouski. 2015. P. 116–122. Recommended literature: study the literature from the theme № 9 to № 17. Questions to the test control: Учебное издание БИООРГАНИЧЕСКАЯ ХИМИЯ Ответственная за выпуск O. H. Ринейская