ENGLISH

Human genetics and genomics : a practical guide

By Bahar Taneri; Yagmur Esemen; Esra Asilmaz; Seniye Targen; Türem Delikurt; Pembe Savas

Book information

Publisher
Wiley-VCH
Year
2020
ISBN
9783527682638, 3527682635, 9783527682652, 3527682651
Language
english
Format
PDF
Filesize
8 MB (7873400 bytes)
Pages
\157
Time added
2021-08-05 11:57:05

Description

Cover Title Page Copyright Contents About the Authors Introduction Chapter 1 Exploring Online Genetics Sources Background Human Genome Project National Center for Biotechnology Information (NCBI) UCSC Genome Browser The Encyclopedia of DNA Elements (ENCODE) Roadmap Epigenomic Project References Exercise Questions Additional Exercise Questions Chapter 2 Observation of Human Inheritance Background Mendelian Genetics The Transmission of Hereditary Characteristics Mendelian Disorders References Exercise Questions Additional Exercise Questions Chapter 3 Reading, Understanding, and Constructing Human Pedigrees Background Basic Pedigree Nomenclature Modes of Inheritance Autosomal Recessive Inheritance Pedigrees Representing Autosomal Recessive Inheritance Autosomal Dominant Inheritance Pedigrees Representing Autosomal Dominant Inheritance X‐Linked Recessive Inheritance Pedigrees Representing X‐Linked Recessive Inheritance X‐Linked Dominant Inheritance Pedigrees Representing X‐Linked Dominant Inheritance Y‐Linked Inheritance Pedigrees Representing Y‐Linked Inheritance Non‐Mendelian Patterns of Inheritance Confounding Factors in Pedigree Generation and Interpretation References Exercise Questions Additional Exercise Questions Chapter 4 Cytogenetics Background Generation of Karyograms/Chromosome Banding FISH, Fluorescent In Situ Hybridization Comparative Genomic Hybridization (CGH) and Array‐Based CGH Technology Chromosomal Abnormalities Numerical Chromosomal Abnormalities Structural Chromosomal Abnormalities References Exercise Questions Additional Exercise Questions Chapter 5 Exploring DNA, RNA, and Protein Sequence Databases and Genome Browsers Background General Biological Databases RNA‐Specific Databases Protein‐Specific Databases Regulatory DNA Database Genome Browsers References Exercise Questions Additional Exercise Questions Chapter 6 Exploring Online Bioinformatics Tools Background BLAST ExPASy Clustal Omega Reactome References Exercise Questions Additional Exercise Questions Chapter 7 Multifactorial Inheritance and Common Complex Diseases Background Polygenic Complex Diseases Investigating Complex Traits Obesity as a Complex Disease Diabetes Mellitus Type 2 as a Complex Disease Coronary Artery Diseases as Complex Diseases References Exercise Questions Additional Exercise Questions Chapter 8 Neurogenetics and Behavioral Genetics Background Genetic Regulation of Neural Development Structure and Function of the Nervous System Understanding the Genetics of Neurological Disease Examples of Neurogenetic Disorders Huntington's Disease Parkinson's Disease Rett Syndrome Behavioral Genetics Genetics of Depression Genetics of Drug Addiction Genetics of Schizophrenia References Exercise Questions Additional Exercise Questions Chapter 9 Cancer Genetics Background Cell Cycle and Its Regulation Oncogenes and Tumor Suppressor Genes Carcinogens/Environmental Factors in Cancer Breast Cancer Role of Molecular Medicine in Breast Cancer Treatment Recent Advances in Cancer Diagnosis and Treatment References Exercise Questions Additional Exercise Questions Chapter 10 Genetic Counseling Background References Exercise Questions Additional Exercise Questions Chapter 11 Evolving Tools in Genome Editing: CRISPR‐Cas Background Mechanism of CRISPR‐Cas9 System Applications of CRISPR‐Cas9 System Generation of Animal Models and Engineering Cells Somatic Genome Editing Repair of Genetic Disorders Functional Genomic Screening Treatment of Infectious Diseases Other Applications of CRISPR‐Cas9 System References Acknowledgment Exercise Questions Additional Exercise Questions Glossary Index EULA

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