Ciba Foundation Symposium - Breathing: Hering-Breuer Centenary Symposium

Description

Volume 1 Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs successfully upholds the goals of the Wiley Encyclopedia of Clinical Trials by combining both previously-published and newly developed contributions written by over 100 leading academics, researchers, and practitioners in a comprehensive, approachable format. The result is a succinct reference that unveils modern, cutting-edge approaches to acquiring and understanding data throughout the various stages of clinical trial design and analysis. Volume 2Featuring newly-written material as well as established literature from the Wiley Encyclopedia of Clinical Trials, this book provides a timely and authoritative review of techniques for planning clinical trials as well as the necessary inferential methods for analyzing collected data. This comprehensive volume features established and newly-written literature on the key statistical principles and concepts for designing modern-day clinical trials, such as hazard ratio, flexible designs, confounding, covariates, missing data, and longitudinal data. Examples of ongoing, cutting-edge clinical trials from today's research such as early cancer & heart disease, mother to child human immunodeficiency virus transmission, women's health initiative dietary, and AIDS clinical trials are also explored. Content: Chapter 1 Chairman's Opening Remarks (page 1): A. C. DornhorstChapter 2 About Hering and Breuer (pages 3–15): Elisabeth UllmannChapter 3 The Role of Vagal Inflation Reflexes in Man and Other Animals (pages 17–40): A. Guz, M. I. M. Noble, H. Eisele and Diana TrenchardChapter 4 Pattern of Breathing During Hypercapnia Before and After Vagal Blockade in Man (pages 41–52): A. Guz and J. G. WiddicombeChapter 5 Neural Control of Respiration (pages 53–58): S. I. FranksteinChapter 6 The Mechanism of Excitation of Type J Receptors, and the J Reflex (pages 59–76): A. S. PaintalChapter 7 Epithelial Irritant Receptors in the Lungs (pages 77–99): Janet E. Mills, Hilary Sellick and J. G. WiddicombeChapter 8 Sensory Innervation of the Airways (pages 101–124): Marianne Fillenz and R. I. WoodsChapter 9 How Respiratory Rhythm Originates: Evidence from Discharge Patterns of Brainstem Respiratory Neurones (pages 125–157): M. I. CohenChapter 10 Neurological Integration of Behavioural and Metabolic Control OF Breathing (pages 159–181): Fred PlumChapter 11 Patterns of Motor Activity in Breathing in Response to Varying Sensory Inputs (pages 183–206): A. A. ViljanenChapter 12 The Sense of Effort (pages 207–217): P. A. MertonChapter 13 The Role of Afferent Impulses from the Lung and Chest Wall in Respiratory Control and Sensation (pages 219–232): S. Godfrey and E.J.M. CampbellChapter 14 Effect of Selective Peripheral Nerve Blocks on Respiratory Sensations (pages 233–251): M.I.M. Noble, H. Eiseled, Diana Trenchard and A. GuzChapter 15 Some Psychological and Physiological Considerations of Breathlessness (pages 253–286): R.C.B. Aitken, A. K. Zealleayn and S. V. RosenthalChapter 16 Respiratory Sensation in Pulmonary Disease (pages 287–295): J.B.L. HowellChapter 17 Breathing Frequency and Tidal Volume: Relationship to Breathlessness (pages 297–314): J. E. Cotes, G. R. Johnson and Ann McdonaldChapter 18 Experimental Results of Vagal Block in Cardiopulmonary Disease (pages 315–353): A. Guz, M.I.M. Noble, J. H. Eisele and Diana TrenchardChapter 19 Chairman's Closing Remarks (pages 355–356): A. C. DornhorstChapter 20 The Two Original Papers by Hering and Breuer Submitted by Hering to the K.K. Akademie Der Wissenschaften Zu Wien in 1868 (pages 357–394): Elisabeth Ullmann