HIV-1 Latency

Description

This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public. Front Matter ....Pages i-vii Molecular Control of HIV and SIV Latency (Gilles Darcis, Benoit Van Driessche, Sophie Bouchat, Frank Kirchhoff, Carine Van Lint)....Pages 1-22 Assays to Measure Latency, Reservoirs, and Reactivation (Janet D. Siliciano, Robert F. Siliciano)....Pages 23-41 The Antiviral Immune Response and Its Impact on the HIV-1 Reservoir (Rebecca T. Veenhuis, Joel N. Blankson)....Pages 43-67 Nonhuman Primate Models for Studies of AIDS Virus Persistence During Suppressive Combination Antiretroviral Therapy (Gregory Q. Del Prete, Jeffrey D. Lifson)....Pages 69-109 SIV Latency in Macrophages in the CNS (Lucio Gama, Celina Abreu, Erin N. Shirk, Suzanne E. Queen, Sarah E. Beck, Kelly A. Metcalf Pate et al.)....Pages 111-130 Mathematical Models of HIV Latency (Alison L. Hill)....Pages 131-156 Residual Immune Activation and Latency (Elena Bruzzesi, Irini Sereti)....Pages 157-180 Immune Interventions to Eliminate the HIV Reservoir (Denise C. Hsu, Jintanat Ananworanich)....Pages 181-210 Cell and Gene Therapy for HIV Cure (Christopher W. Peterson, Hans-Peter Kiem)....Pages 211-248