Pathophysiological Aspects of Proteases

Description

This book provides a comprehensive overview of the multifaceted field of protease in the cellular environment and focuses on the recently elucidated functions of complex proteolytic systems in physiology and pathophysiology. Given the breadth and depth of information covered in the respective contributions, the book will be immensely useful for researchers working to identify targets for drug development. Multidisciplinary in scope, the book bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry, making it a thought-provoking read for basic and applied scientists engaged in biomedical research. Proteases represent one of the largest and most diverse families of enzymes known, and we now know that they are involved in every aspect of a given organism’s life functions. Under physiological conditions, proteases are regulated by their endogenous inhibitors. However, when the activity of proteases is not correctly regulated, disease processes such as tumour progression, vascular remodelling, atherosclerotic plaque progression, ulcer, rheumatoid arthritis, Alzheimer’s disease and inflammation can result. Many infective microorganisms require proteases for replication or use them as virulence factors, which has facilitated the development of protease-targeted therapies for a variety of parasitic diseases. Front Matter ....Pages i-xv Front Matter ....Pages 1-1 Role of Proteases in Breast Cancer (Sandra Radenkovic, Kristina Gopcevic, Gordana Konjevic, Vladimir Jurisic)....Pages 3-22 The Multifunctional Post-proline Dipeptidyl Peptidase, DPP9, in Mice, Cell Biology and Immunity (Margaret G. Gall, Mark D. Gorrell)....Pages 23-45 The γ-Secretase Protease Complexes in Neurodegeneration, Cancer and Immunity (Caroline Coleman-Vaughan, Arijit Mal, Abhijit De, Justin V. McCarthy)....Pages 47-87 The Role of Urinary Proteases in Bladder Cancer (Paulo Bastos, Sandra Magalhães, Lúcio Lara Santos, Rita Ferreira, Rui Vitorino)....Pages 89-118 Endogenous Proteases in Tumoral Progression (Dalton Dittz Júnior, Fernanda de Oliveira Lemos, Ana Candida Araujo e Silva)....Pages 119-145 Tripeptidyl Peptidase I and Its Role in Neurodegenerative and Tumor Diseases (Mashenka B. Dimitrova, Dimitrinka Y. Atanasova, Nikolai E. Lazarov)....Pages 147-160 Calpain Activity and Expression in Human Colonic Tumors (Rajendra K. Sharma, Umashankar Das, Sreejit Parameswaran, Sujeet Kumar, Jonathan R. Dimmock)....Pages 161-170 Role of Cathepsins, in Particular Cathepsins B and D in Breast Cancer: Mechanisms and Clinical Implications (Anuradha Ratna, Salil K. Das)....Pages 171-189 PAR1-Mediated Apoptosis and Tumor Regression of Breast Cancer Cells by Vibrio cholerae Hemagglutinin Protease (Tanusree Ray, Amit Pal)....Pages 191-205 Matrix Metalloproteinases (MMPs) in Cancer Initiation and Progression (Sanjeev Kumar Maurya, Nitesh Poddar, Pallavi Tandon, Ajit Kumar Yadav)....Pages 207-236 Proteolytic Networks at the Crossroads of Cancer Cell Life and Death: Cancer Stem Cell Deciding Cell Fate (Poulami Khan, Shruti Banerjee, Apoorva Bhattacharya, Dipanwita Dutta Chowdhury, Apratim Dutta, Tanya Das)....Pages 237-263 Role of Proteases in Tumor Immune Evasion (Abir K. Panda, Sreeparna Chakraborty, Kirti Kajal, Dia Roy, Tania Sarkar, Gaurisankar Sa)....Pages 265-296 Protease, an Advance Therapeutic Target in Cancer (Animesh Chowdhury, Donatella Romaniello, Soma Ghosh, Tapati Chakraborti, Soumitra Roy, Sajal Chakraborti)....Pages 297-317 Front Matter ....Pages 319-319 Matrix Metalloproteinases in Parasitic Infections (Fabrizio Bruschi, Barbara Pinto)....Pages 321-352 Roles of Candida albicans Aspartic Proteases in Host-Pathogen Interactions (Mariusz Gogol, Oliwia Bochenska, Marcin Zawrotniak, Justyna Karkowska-Kuleta, Dorota Zajac, Maria Rapala-Kozik)....Pages 353-380 Pseudomonas aeruginosa and Its Arsenal of Proteases: Weapons to Battle the Host (Anna Clara M. Galdino, Marta H. Branquinha, André L. S. Santos, Lívia Viganor)....Pages 381-397 Serine Proteases as Metabolic Regulators in Yeast (Alexis N. Campetelli, Noelia E. Monesterolo)....Pages 399-422 Caspases: Regulatory Mechanisms and Their Implications in Pathogenesis and Therapeutics (Aasna L. Parui, Kakoli Bose)....Pages 423-488 Gastric Pathology and Metalloproteinases (Snehasikta Swarnakar, Anirban Roy, Satyabrata Ghosh, Rajib Majumder, Sandip Paul)....Pages 489-513 Role of Proteases in Diabetes Mellitus (Shatadal Ghosh, Bhawna Pandey, Parames C. Sil)....Pages 515-533 Role of Proteases in Regulating Cell Death Pathways (Thomas Divya, Sekar Vasudevan, Ganapasam Sudhandiran)....Pages 535-551 Role of Proteases in Idiopathic Pulmonary Fibrosis (Soumya Chatterjee, Kaustav Chakraborty, Subhabrata Moitra, Arindam Bhattacharyya)....Pages 553-566 Protease-Activated Receptor Signaling in Lung Pathology (Ganapasam Sudhandiran, Srinivasan Kalayarasan, Thomas Divya, Bakthavatchalam Velavan)....Pages 567-581 Unfolding the Mechanism of Proteases in Pathophysiology of Gastrointestinal Diseases (Sharmistha Banerjee, Sumit Ghosh, Krishnendu Sinha, Parames C. Sil)....Pages 583-603 Matrix Metalloproteases: Potential Role in Type 2 Diabetic Nephropathy (Gantala Srilatha Reddy, Hanumanth Surekha Rani)....Pages 605-616 Antihypertensive Role of Kidney: Focus on Tissue Kallikreins (Amritlal Mandal, Tapati Chakraborti, Sajal Chakraborti)....Pages 617-634 Proteases—The Sharp Scissors in Human Diseases (Sandipan Chakraborty, Soumalee Basu)....Pages 635-645 Pathophysiological Aspects of Aspergillus sp. (Tapan Kumar Das)....Pages 647-655 Cysteine Proteases of Parasitic Helminths (Alok K. Dixit, Pooja Dixit, Ramji L. Sharma)....Pages 657-671