ENGLISH

Metallopharmaceuticals I: DNA Interactions

By Stephen J. Lippard (auth.) , Andrew Gelasco , Professor Michael J. Clarke , Professor Peter J. Sadler (eds.)

Book information

Publisher
Springer-Verlag Berlin Heidelberg
Year
1999
ISBN
978-3-642-08440-9, 978-3-662-03815-4
DOI
10.1007/978-3-662-03815-4
Language
english
Format
PDF
Filesize
4 MB (3988423 bytes)
Series
Topics in Biological Inorganic Chemistry 1
Edition
1
Pages
200\204
Orientation
yes
Scanned
yes
Time added
2013-08-01 04:00:00
Biochemistrygeneral; Inorganic Chemistry; Molecular Medicine;

Description

Inorganic compounds offer much scope for the design of novel and therapeutic agents. The widespread use of paramagnetic metal complexes as effective contrast agents for magnetic resonsance imaging (e.g. Gd) demonstrates that the toxicity of metals can be finely controlled via the approriate choice of ligands. The successful targeting of radioisotopes again depends on ligand design and metal oxidation state. Bismuth and gold complexes have long been used in medicine but only recently have advances been made in understanding the molecular basis of their mechanism of action. New areas with clinical potential include the use of polyoxometallates and fullerenes as antiviral agents and vanadium complexes as insulin mimetics.

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