ENGLISH

Trypanosomatid Diseases: Molecular Routes to Drug Discovery

By Paul M. Selzer(eds.)

Book information

ISBN
9783527332557, 9783527670383
DOI
10.1002/9783527670383
Language
english
Format
PDF
Filesize
20 MB (20658192 bytes)
Pages
555\555
Orientation
yes
Scanned
yes
Time added
2013-08-01 04:00:00

Description

Content: Chapter 1 Visceral Leishmaniasis – Current Treatments and Needs (pages 1–15): Poonam Salotra, Ruchi Singh and Karin SeifertChapter 2 Chemotherapy of Leishmaniasis: A Veterinary Perspective (pages 17–35): Maria Jesus Corral?Caridad and Jose Maria AlundaChapter 3 Pharmacological Metabolomics in Trypanosomes (pages 37–56): Darren J. Creek, Isabel M. Vincent and Michael P. BarrettChapter 4 Drug Design and Screening by In Silico Approaches (pages 57–79): Mattia Mori and Maurizio BottaChapter 5 Computational Approaches and Collaborative Drug Discovery for Trypanosomal Diseases (pages 81–102): Sean Ekins and Barry A. BuninChapter 6 Interaction of Leishmania Parasites with Host Cells and its Functional Consequences (pages 103–119): Uta Schurigt, Anita Masic and Heidrun MollChapter 7 Function of Glycosomes in the Metabolism of Trypanosomatid Parasites and the Promise of Glycosomal Proteins as Drug Targets (pages 121–151): Melisa Gualdron?Lopez, Paul A. M. Michels, Wilfredo Quinones, Ana J. Caceres, Luisana Avilan and Juan?Luis ConcepcionChapter 8 Glyoxalase Enzymes in Trypanosomatids (pages 153–166): Marta Sousa Silva, Antonio E. N. Ferreira, Ricardo Gomes, Ana M. Tomas, Ana Ponces Freire and Carlos CordeiroChapter 9 Trypanothione?Based Redox Metabolism of Trypanosomatids (pages 167–199): Marcelo A. Comini and Prof. Dr.med. Dr.h.c. Leopold FloheChapter 10 Thiol Peroxidases of Trypanosomatids (pages 201–213): Helena Castro and Ana M. TomasChapter 11 Peroxynitrite as a Cytotoxic Effector Against Trypanosoma Cruzi: Oxidative Killing and Antioxidant Resistance Mechanisms (pages 215–236): Madia Trujillo, Maria Noel Alvarez, Lucia Piacenza, Martin Hugo, Gonzalo Peluffo and Rafael RadiChapter 12 Selenoproteome of Kinetoplastids (pages 237–242): Alexei V. Lobanov and Vadim N. GladyshevChapter 13 Replication Machinery of Kinetoplast DNA (pages 243–260): Rachel Bezalel?Buch, Nurit Yaffe and Joseph ShlomaiChapter 14 Life and Death of Trypanosoma Brucei: New Perspectives for Drug Development (pages 261–277): Torsten Barth, Jasmin Stein, Stefan Mogk, Caroline Schonfeld, Bruno K. Kubata and Michael DuszenkoChapter 15 Rational Selection of Anti?Microbial Drug Targets: Unique or Conserved? (pages 279–296): Boris Rodenko and Harry P. de KoningChapter 16 Drug Targets in Trypanosomal and Leishmanial Pentose Phosphate Pathway (pages 297–313): Marcelo A. Comini, Cecilia Ortiz and Juan Jose CazzuloChapter 17 GDP?Mannose: A Key Point for Target Identification and Drug Design in Kinetoplastids (pages 315–334): Sebastien Pomel and Philippe M. LoiseauChapter 18 Transporters in Anti?Parasitic Drug Development and Resistance (pages 335–349): Vincent Delespaux and Harry P. de KoningChapter 19 Peptidases in Autophagy are Therapeutic Targets for Leishmaniasis (pages 351–364): Roderick A. M. WilliamsChapter 20 Proteases of Trypanosoma brucei (pages 365–382): Dietmar SteverdingChapter 21 Screening Approaches Towards Trypanothione Reductase (pages 383–404): Mathias Beig, Frank Oellien, R. Luise Krauth?Siegel and Prof. Dr. Paul M. SelzerChapter 22 Redox?Active Agents in Reactions Involving the Trypanothione/Trypanothione Reductase?based System to Fight Kinetoplastidal Parasites (pages 405–428): Thibault Gendron, Don Antoine Lanfranchi and Elisabeth Davioud?CharvetChapter 23 Inhibition of Trypanothione Synthetase as a Therapeutic Concept (pages 429–443): Dr. Oliver Koch, Dr. Timo Jager, Prof. Dr.med. Dr.h.c. Leopold Flohe and Prof. Dr. Paul M. SelzerChapter 24 Targeting the Trypanosomatidic Enzymes Pteridine Reductase and Dihydrofolate Reductase (pages 445–472): Stefania Ferrari, Valeria Losasso, Puneet Saxena and Maria Paola CostiChapter 25 Contribution to New Therapies for Chagas Disease (pages 473–487): Patricia S. Doyle and Juan C. EngelChapter 26 Ergosterol Biosynthesis for the Specific Treatment of Chagas Disease: From Basic Science to Clinical Trials (pages 489–514): Julio A. UrbinaChapter 27 New Developments in the Treatment of Late?Stage Human African Trypanosomiasis (pages 515–529): Cyrus J. Bacchi, Robert T. Jacobs and Nigel Yarlett

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