ENGLISH

Wnt Signaling: Methods and Protocols

By Quinn Barrett , Lawrence Lum

Book information

Publisher
Humana Press
Year
2016
ISBN
1493963910, 9781493963911
DOI
10.1007/978-1-4939-6393-5
ISSN
1064-3745
Language
english
Format
PDF
Filesize
6 MB (6228942 bytes)
Series
Methods in Molecular Biology 1481
Pages
xii+198\211
Topic
Biology Molecular
Orientation
yes
Paginated
yes
Scanned
portrait
Time added
2016-09-04 22:15:23
Cell Biology

Description

Now poised to evaluate the potential in modulating Wnt signaling for therapeutic agendas in cancer, wound healing, and degenerative disease, this book collects protocols from an exciting area of study. The methodologies include using Wnt modulating chemicals in engineering tissues from induced pluripotent and embryonic stem cells, monitoring Wnt transcriptional responses in diverse tissues such as bone and skin, and using specific biochemical markers of Wnt signaling to either screen molecular libraries or evaluate novel reagents. These protocols also leverage unique experimental strengths from five different model organisms. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and authoritative, Wnt Signaling: Methods and Protocols aims to support researchers in understanding Wnt signal transduction in any effort to improve outcomes in regenerative medicine and cancer management.

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