Molecular Determinants of Head and Neck Cancer

Description

Squamous cell cancers of the head and neck (SCCHN), also known as head and neck cancers (HNC) encompass malignancies of the oral cavity, larynx, nasopharynx and pharynx, and are diagnosed in over 500,000 patients worldwide each year, accounting for 5% of all malignancies. It is estimated that approximately 50,000 patients develop head and neck cancer annually in the United States, of whom approximately 50% succumb to this cancer. For most cases of SCCHN, treatment is multimodal, often combining surgery or irradiation with chemotherapy; even successfully treated patients frequently experience durable and severe side effects. Improving cure rates and reducing chronic morbidity are urgent clinical needs for head and neck cancer. However, in contrast to cancer types such as breast or prostate that have been much studied and have well-defined biology, until recently, relatively few researchers investigated the molecular basis of HNC, making it difficult to design targeted treatments with better efficacy and less debilitating side effects. This volume will provide an overview of the factors contributing to disease pathogenesis, including the recognition of discrete molecular subtypes with distinct etiology, prognosis, and treatment response. This volume will familiarize the reader with the critical signaling pathways and oncogenic drivers for HNC. It will outline the differences between HPV-positive and HPV-negative disease, and how these differences affect treatment choice and outcome. The book will emphasize developments in the past five years, including the growing understanding of the genomic and epigenomic features of the disease based on analysis of next generation sequencing (NGS) data, and timely topics such as the analysis of HNC stem cell populations, non-coding mRNAs, and inflammatory response. It will address exciting new therapeutic approaches such as the use of immunotherapies to treat HNC patients. Overall, the book will provide the reader with current understanding of the biology and treatment of the disease, and describe timely questions that will guide future research aimed at controlling and curing this disease. Front Matter ....Pages i-vi Overview: The Pathobiology of Head and Neck Cancer (Barbara Burtness, Erica A. Golemis)....Pages 1-5 Targeting the ErbB Family in Head and Neck Cancer (Anna Kiseleva, Tim N. Beck, Ilya G. Serebriiskii, Hanqing Liu, Barbara Burtness, Erica A. Golemis)....Pages 7-61 c-MET in Head and Neck Squamous Cell Carcinoma (John Kaczmar, Tim N. Beck)....Pages 63-88 Transforming Growth Factor Beta (TGF-β) Signaling in Head and Neck Squamous Cell Carcinoma (HNSCC) (Alexander E. Kudinov, Tim N. Beck)....Pages 89-115 The PI3K Signaling Pathway in Head and Neck Squamous Cell Carcinoma (Alexander Y. Deneka, Jason D. Howard, Christine H. Chung)....Pages 117-154 Jak/STAT Signaling in Head and Neck Cancer (Elizabeth Cedars, Daniel E. Johnson, Jennifer R. Grandis)....Pages 155-184 Molecular Regulation of Cell Cycle and Cell Cycle-Targeted Therapies in Head and Neck Squamous Cell Carcinoma (HNSCC) (Elena V. Demidova, Waleed Iqbal, Sanjeevani Arora)....Pages 185-227 Role of the NOTCH Signaling Pathway in Head and Neck Cancer (Adrian D. Schubert, Fernando T. Zamuner, Nyall R. London Jr, Alex Zhavoronkov, Ranee Mehra, Mohammad O. Hoque et al.)....Pages 229-248 P53 in Head and Neck Squamous Cell Carcinoma (Janaki Parameswaran, Barbara Burtness)....Pages 249-274 APOBEC as an Endogenous Mutagen in Cancers of the Head and Neck (Tomoaki Sasaki, Natalia Issaeva, Wendell G. Yarbrough, Karen S. Anderson)....Pages 275-292 The Genome-Wide Molecular Landscape of HPV-Driven and HPV-Negative Head and Neck Squamous Cell Carcinoma (Farhoud Faraji, Adrian D. Schubert, Luciane T. Kagohara, Marietta Tan, Yanxun Xu, Munfarid Zaidi et al.)....Pages 293-325 Epigenetic Changes and Epigenetic Targets in Head and Neck Cancer (Suraj Peri, Andrew J. Andrews, Aarti Bhatia, Ranee Mehra)....Pages 327-352 Inflammation and Head and Neck Squamous Cell Carcinoma (Paul E. Clavijo, Clint T. Allen, Nicole C. Schmitt, Carter Van Waes)....Pages 353-364 Immunotherapy in Head and Neck Squamous Cell Carcinoma (HNSCC) (Jennifer Moy, Robert L. Ferris)....Pages 365-396 The Clinical Impact of Hypoxia in Head and Neck Squamous Cell Carcinoma (Annette M. Lim, Quynh-Thu Le, Danny Rischin)....Pages 397-438 Angiogenesis and Anti-angiogenic Therapy in Head and Neck Cancer (Lindsay Wilde, Jennifer Johnson, Athanassios Argiris)....Pages 439-467 FAK as a Target for Therapy in Head and Neck Cancer (Nassim Khosravi, Heath Skinner, John Heymach)....Pages 469-490 Diversity of Wnt/β-Catenin Signaling in Head and Neck Cancer: Cancer Stem Cells, Epithelial-to-Mesenchymal Transition, and Tumor Microenvironment (Khalid Alamoud, Maria A. Kukuruzinska)....Pages 491-524 Hyaluronan-Mediated CD44 Signaling Activates Cancer Stem Cells in Head and Neck Cancer (Lilly Y. W. Bourguignon)....Pages 525-544 Biology and Epidemiology of Human Papillomavirus-Related Head and Neck Cancer (Alexander Y. Deneka, Jeffrey C. Liu, Camille C. R. Ragin)....Pages 545-583 Treatment Paradigms in HPV-Associated SCCHN (Christien A. Kluwe, Anthony J. Cmelak)....Pages 585-615 Back Matter ....Pages 617-629