ENGLISH

Carbohydrate-Based Drug Discovery

Book information

ISBN
9783527306329, 9783527602438
DOI
10.1002/3527602437
Language
english
Format
PDF
Filesize
17 MB (17408413 bytes)
Pages
956\956
Orientation
yes
Scanned
yes
Time added
2013-08-01 04:00:00

Description

Content: Chapter 1 Synthetic Methodologies (pages 1–36): Chikako Saotome and Osamu KanieChapter 2 Complex Carbohydrate Synthesis (pages 37–54): Makoto Kiso, Hideharu Ishida and Hiromune AndoChapter 3 The Chemistry of Sialic Acid (pages 55–102): Geert?Jan Boons and Alexei V. DemchenkoChapter 4 Solid?Phase Oligosaccharide Synthesis (pages 103–127): Peter H. SeebergerChapter 5 Solution and Polymer?Supported Synthesis of Carbohydrates (pages 129–136): Shin?Ichiro NishimuraChapter 6 Enzymatic Synthesis of Oligosaccharides (pages 137–167): Jianbo Zhang, Jun Shao, Prezemk Kowal and Peng George WangChapter 7 Glycopeptides and Glycoproteins: Synthetic Chemistry and Biology (pages 169–214): Oliver SeitzChapter 8 Synthesis of Complex Carbohydrates: Everninomicin (pages 215–252): K. C. Nicolaou, Helen J. Mitchell and Scott A. SnyderChapter 9 Chemical Synthesis of Asparagine?Linked Glycoprotein Oligosaccharides: Recent Examples (pages 253–280): Yukishige Ito and Ichiro MatsuoChapter 10 Chemistry and Biochemistry of Asparagine?Linked Protein Glycosylation (pages 281–303): Barbara Imperiali and Vincent W.?F. TaiChapter 11 Conformational Analysis of C?Glycosides and Related Compounds: Programming Conformational Profiles of C? and O?Glycosides (pages 305–340): Peter G. Goekjian, Alexander Wei and Yoshito KishiChapter 12 Synthetic Lipid A Antagonists for Sepsis Treatment (pages 341–355): William J. Christ, Lynn D. Hawkins, Michael D. Lewis and Yoshito KishiChapter 13 Polysialic Acid Vaccines (pages 357–380): Harold J. JenningsChapter 14 Synthetic Carbohydrate?Based Vaccines (pages 381–406): Stacy J. Keding and Samuel J. DanishefskyChapter 15 Chemistry, Biochemistry, and Pharmaceutical Potentials of Glycosaminoglycans and Related Saccharides (pages 407–439): Tasneem Islam and Robert J. LinhardtChapter 16 A New Generation of Antithrombotics Based on Synthetic Oligosaccharides (pages 441–459): Maurice Petitou and Jean?Marc HerbertChapter 17 Sequencing of Oligosaccharides and Glycoproteins (pages 461–482): Stuart M. Haslam, Kay?Hooi Khoo and Anne DellChapter 18 Preparation of Heterocyclic 2?Deoxystreptamine Aminoglycoside Analogues and Characterization of Their Interaction with RNAs by Use of Electrospray Ionization Mass Spectrometry (pages 483–499): Richard H. Griffey, Steven A. Hofstadler and Eric E. SwayzeChapter 19 Glycosylation Analysis of a Recombinant P?Selectin Antagonist by High?pH Anion?Exchange Chromatography with Pulsed Electrochemical Detection (HPAEC/PED) (pages 501–516): Mark R. Hardy and Richard J. CornellChapter 20 Analytical Techniques for the Characterization and Sequencing of Glycosaminoglycans (pages 517–539): Ram Sasisekharan, Zachary Shriver, Mallik Sundaram and Ganesh VenkataramanChapter 21 Thermodynamic Models of the Multivalency Effect (pages 541–574): Pavel I. Kitov and David R. BundleChapter 22 Synthetic Multivalent Carbohydrate Ligands as Effectors or Inhibitors of Biological Processes (pages 575–608): Laura L. Kiessling, Jason K. Pontrello and Michael C. SchusterChapter 23 Glycosyltransferase Inhibitors (pages 609–659): Karl?Heinz Jung and Richard R. SchmidtChapter 24 RNA?Aminoglycoside Interactions (pages 661–683): Haim Weizman and Yitzhak TorChapter 25 Glycosylated Natural Products (pages 685–711): Jon S. Thorson and Thomas VogtChapter 26 Novel Enzymatic Mechanisms in the Biosynthesis of Unusual Sugars (pages 713–745): Alexander Wong, Xuemei He and Hung?Wen LiuChapter 27 Neoglycolipids: Identification of Functional Carbohydrate Epitopes (pages 747–760): Ten Feizi, Alexander M. Lawson and Wengang ChaiChapter 28 A Preamble to Aglycone Reconstruction for Membrane?Presented Glycolipid Mimics (pages 761–779): Murugesapillai Mylvaganam and Clifford A. LingwoodChapter 29 Small Molecule Inhibitors of the Sulfotransferases (pages 781–801): Dawn E. Verdugo, Lars C. Pedersen and Carolyn R. BertozziChapter 30 Carbohydrate?Based Treatment of Cancer Metastasis (pages 803–829): Reiji KannagiChapter 31 N?Acetylneuraminic Acid Derivatives and Mimetics as Anti?Influenza Agents (pages 831–861): Robin Thomson and Mark von ItzsteinChapter 32 Modified and Modifying Sugars as a New Tool for the Development of Therapeutic Agents – The Biochemically Engineered N?Acyl Side Chain of Sialic Acid: Biological Implications and Possible Uses in Medicine (pages 863–873): Rudiger Horstkorte, Oliver T. Keppler and Werner ReutterChapter 33 Modified and Modifying Sugars as a New Tool for the Development of Therapeutic Agents – Glycosidated Phospholipids as a New Type of Antiproliferative Agents (pages 875–882): Kerstin Danker, Annette Fischer and Werner ReutterChapter 34 Glycoside Primers and Inhibitors of Glycosylation (pages 883–898): Jillian R. Brown, Mark M. Fuster and Jeffrey D. EskoChapter 35 Carbohydrate?Based Drug Discovery in the Battle against Bacterial Infections: New Opportunities Arising from Programmable One?Pot Oligosaccharide Synthesis (pages 899–932): Thomas K. Ritter and Prof. Dr. Chi?Huey Wong

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