Goodman and Gilman's The Pharmacological Basis of Therapeutics, 14th Edition

Description

The landmark pharmacology reference―updated to reflect the latest research and developments in the field For more than 50 years, Goodman & Gilman’s: The Pharmacological Basis of Therapeutics has represented the pinnacle of authority and accuracy in describing the actions and uses of therapeutic agents in relation to physiology and pathophysiology. The text's careful balance of basic science and clinical applications has guided thousands of health care practitioners and students to a clear understanding of the drugs essential to preventing, diagnosing and treating disease. This Fourteenth Edition includes five new chapters, 600+ illustrations, and important content from 53 new contributors. More than a textbook, Goodman & Gilman’s is a working template for the effective and rational prescribing of drugs in daily practice. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics, Fourteenth Edition features: Five NEW chapters on: -Pharmacovigilance -The blood-brain barrier -Cannabis -Antibodies, immune checkpoint inhibitors, CAR-T cells, and other biological agents -Gastrointestinal microbiome and drug response  Expanded coverage of the use of genetic polymorphisms in designing appropriate therapiesRevised and expanded chapter on pharmacodynamics and the molecular mechanisms of drug action600+ color illustrationsDrug Fact Tables summarizing clinical pharmacologyContent Outline and Abbreviation List at the beginning of each chapter50 NEW figures on mechanism of drug actions53 NEW contributorsNEW online updates Chapter 1_ Drug Discovery_ From Medicinal Plants to Computer-Aided Drug Design Chapter 2_ Pharmacokinetics_ The Dynamics of Drug Absorption, Distribution, Metabolism, and Elimination Chapter 3_ Pharmacodynamics_ Molecular Mechanisms of Drug Action Chapter 4_ Membrane Transporters and Drug Response Chapter 5_ Drug Metabolism Chapter 6_ The Gastrointestinal Microbiome and Drug Response Chapter 7_ Pharmacogenetics and Pharmacogenomics Chapter 8_ Postmarketing Drug Safety Chapter 9_ Principles of Clinical Toxicology Chapter 10_ Neurotransmission_ The Autonomic and Somatic Motor Nervous Systems Chapter 11_ Muscarinic Receptor Agonists and Antagonists Chapter 12_ Anticholinesterase Inhibitors and Reactivators Chapter 13_ Neuromuscular Junction and Autonomic Ganglia; Nicotine, Muscle Relaxants, and Spasmolytics Chapter 14_ Adrenergic Agonists and Antagonists Chapter 15_ 5-Hydroxytryptamine (Serotonin) and Dopamine Chapter 16_ Neurotransmission in the Central Nervous System Chapter 17_ The Blood-Brain Barrier and Its Influence on Drug Transport to the Brain Chapter 18_ Drug Therapy of Depression and Anxiety Disorders Chapter 19_ Pharmacotherapy of Psychosis and Mania Chapter 20_ Pharmacotherapy of the Epilepsies Chapter 21_ Treatment of Central Nervous System Degenerative Disorders Chapter 22_ Hypnotics and Sedatives Chapter 23_ Opioid Analgesics Chapter 24_ General Anesthetics and Therapeutic Gases Chapter 25_ Local Anesthetics Chapter 26_ Cannabinoids Chapter 27_ Ethanol Chapter 28_ Drug Use Disorders and Addiction Chapter 29_ Drugs Affecting Renal Excretory Function Chapter 30_ Renin and Angiotensin Chapter 31_ Treatment of Ischemic Heart Disease Chapter 32_ Treatment of Hypertension Chapter 33_ Therapy of Heart Failure Chapter 34_ Antiarrhythmic Drugs Chapter 35_ Treatment of Pulmonary Arterial Hypertension Chapter 36_ Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs Chapter 37_ Drug Therapy for Dyslipidemias Chapter 38_ Introduction to Immunity and Inflammation Chapter 39_ Immunosuppressants, Immunomodulation, and Tolerance Chapter 40_ Immune Globulins and Vaccines Chapter 41_ Lipid-Derived Autacoids_ Eicosanoids and Platelet-Activating Factor Chapter 42_ Pharmacotherapy of Inflammation, Fever, Pain, and Gout Chapter 43_ Histamine, Bradykinin, and Their Antagonists Chapter 44_ Pulmonary Pharmacology Chapter 45_ Hematopoietic Agents_ Growth Factors, Minerals, and Vitamins Chapter 46_ Introduction to Endocrinology_ The Hypothalamic-Pituitary Axis Chapter 46_ Introduction to Endocrinology_ The Hypothalamic-Pituitary Axis (1) Chapter 47_ Thyroid and Antithyroid Drugs Chapter 48_ Estrogens, Progestins, and the Female Reproductive Tract Chapter 49_ Androgens and the Male Reproductive Tract Chapter 50_ Adrenocorticotropic Hormone, Adrenal Steroids, and the Adrenal Cortex Chapter 51_ Endocrine Pancreas and Pharmacotherapy of Diabetes Mellitus and Hypoglycemia Chapter 52_ Agents Affecting Mineral Ion Homeostasis and Bone Turnover Chapter 53_ Pharmacotherapy for Gastric Acidity, Peptic Ulcers, and Gastroesophageal Reflux Disease Chapter 54_ Gastrointestinal Motility and Water Flux, Emesis, and Biliary and Pancreatic Disease Chapter 55_ Pharmacotherapy of Inflammatory Bowel Disease Chapter 56_ General Principles of Antimicrobial Therapy Chapter 57_ DNA Disruptors_ Sulfonamides, Quinolones, and Nitroimidazoles Chapter 58_ Cell Envelope Disruptors_ β-Lactam, Glycopeptide, and Lipopeptide Antibacterials Chapter 59_ Miscellaneous Antibacterials_ Aminoglycosides, Polymyxins, Urinary Antiseptics, Bacteriophages Chapter 60_ Protein Synthesis Inhibitors Chapter 61_ Antifungal Agents Chapter 62_ Antiviral Agents (Nonretroviral) Chapter 63_ Treatment of Viral Hepatitis (HBV_HCV) Chapter 64_ Antiretroviral Agents and Treatment of HIV Infection Chapter 65_ Chemotherapy of Tuberculosis and Nontuberculous Mycobacteria, Including Leprosy Chapter 66_ Chemotherapy of Malaria Chapter 67_ Chemotherapy of Protozoal Infections_ Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections Chapter 68_ Chemotherapy of Helminth Infections Chapter 69_ General Principles in the Pharmacotherapy of Cancer Chapter 70_ Cytotoxics and Antimetabolites Chapter 71_ Protein Kinase Inhibitors and Pathway-Targeted Small Molecules Chapter 72_ Antibodies, CAR T Cells, and Proteins to Treat Cancer Chapter 73_ Hormones, Hormone Receptor Antagonists, and Related Agents in the Therapy of Cancer Chapter 74_ Ocular Pharmacology Chapter 75_ Dermatological Pharmacology Chapter 76_ Environmental Toxicology Appendix I_ Design and Optimization of Dosage Regimens_ Pharmacokinetic Data Appendix II_ Drug-Drug Interactions