Skin Lymphoma: The Illustrated Guide

Description

A complete guide to the diagnosis and management of cutaneous lymphomas and pseudolymphomas Easily misdiagnosed as benign skin diseases, malignant cutaneous lymphomas can present a variety of challenges to trainees and practicing specialists alike. Skin Lymphoma: The Illustrated Guide has been designed to alleviate some of these difficulties, providing all those working in the dermatological field with a complete and easily consulted text on this potentially fatal cancer. Authored by renowned dermatopathologist Professor Lorenzo Cerroni, its exhaustive contents cover the clinical presentations and pathological correlates of cutaneous lymphomas in their various forms, alongside their prognoses and strategies for treatment. This expanded fifth edition features a wealth of enhancements and additions, including new chapters, updated content, and more than 1,300 full-color illustrations. Revised to reflect the most recent World Health Organization (WHO) and European Organization for Research and Treatment of Cancer (EORTC) classifications, its cutting-edge approach to its subject incorporates the latest molecular data, alongside more familiar histopathological and clinical features. The book’s considerable scope has been broadened into new and groundbreaking areas, the details of which are explored in chapters discussing primary cutaneous acral CD8+ T-cell lymphoma, composite lymphomas, and non-neoplastic cutaneous signs of systemic lymphomas, as well as in new sections on previously unexamined entities such as implant–associated anaplastic large cell lymphoma. Fully updated with new genetic data and most recent WHO classifications Contains four newly written chapters Features unconventional presentation sections with commentary on diagnosis Includes more than 1,300 color illustrations Skin Lymphoma: The Illustrated Guide is an indispensable resource forclinical dermatologists, dermatopathologists, and any other medical practitioners and trainees involved in the diagnosis and treatment of skin lymphomas. Half Title......Page 2 Title Page......Page 3 Copyright......Page 4 Dedication......Page 5 Contents......Page 6 List of teaching cases......Page 9 Preface......Page 10 Acknowledgments......Page 12 Examination of patients......Page 13 Histopathology, immunophenotype, and molecular genetics......Page 16 Other methods used in the study of cutaneous lymphoid infiltrates......Page 22 Pseudomalignancy, premalignancy, and early malignancy......Page 23 References......Page 24 Chapter 2 The “parapsoriases”: a riddle, wrapped in a mystery, inside an enigma......Page 26 References......Page 33 Chapter 3 Mycosis fungoides......Page 34 Onset of mycosis fungoides or exacerbation of undiagnosed disease under treatment with immunomodulatory agents......Page 35 Clinical features......Page 37 Association with other diseases......Page 41 Histopathology, immunophenotype, and molecular genetics......Page 43 Histopathologic differential diagnosis from inflammatory conditions......Page 62 Clinical and histopathologic variants......Page 64 Prognosis......Page 102 References......Page 111 Chapter 4 Seary syndrome......Page 124 Onset/progression under systemic therapies for benign inflammatory dermatoses......Page 125 Clinical features......Page 126 Histopathology, immunophenotype, and molecular genetics......Page 128 Treatment......Page 134 Prognosis......Page 135 References......Page 139 Chapter 5 Primary cutaneous CD30+ lymphoproliferative disorders......Page 144 Clinical features......Page 147 Histopathology, immunophenotype, and molecular genetics......Page 148 Clinicopathologic differential diagnosis......Page 157 Treatment......Page 158 Histopathology, immunophenotype, and molecular genetics......Page 165 Treatment......Page 173 Prognosis......Page 175 References......Page 184 Chapter 6 Subcutaneous panniculitis‐like T‐cell lymphoma......Page 191 Clinical features......Page 192 Histopathology, immunophenotype, and molecular genetics......Page 193 Differential diagnosis with other cutaneous NK/T‐cell lymphomas with prominent involvement of the subcutaneous tissue......Page 195 Differential diagnosis with lupus panniculitis......Page 196 Prognosis......Page 198 References......Page 203 Chapter 7 Aggressive cutaneous cytotoxic lymphomas......Page 206 Clinical features......Page 207 Histopathology, immunophenotype, and molecular genetics......Page 208 Clinical features......Page 214 Histopathology, immunophenotype, and molecular genetics......Page 215 Treatment......Page 218 Prognosis......Page 219 Histopathology, immunophenotype, and molecular genetics......Page 220 Treatment......Page 224 Prognosis......Page 225 References......Page 227 Clinical features......Page 230 Histopathology, immunophenotype, and molecular genetics......Page 232 Prognosis......Page 236 References......Page 237 Chapter 9 Cutaneous CD4+ small/medium T‐cell lymphoproliferative disorder......Page 239 Treatment......Page 240 Prognosis......Page 241 Final considerations......Page 243 References......Page 244 Histopathology, immunophenotype, and molecular genetics......Page 246 Prognosis......Page 247 References......Page 249 Histopathology, immunophenotype, and molecular genetics......Page 250 Treatment and prognosis......Page 252 References......Page 253 Clinical features, histopathology, immunophenotype, and molecular genetics......Page 254 Treatment and prognosis......Page 257 Clinical features, histopathology, immunophenotype, and molecular genetics......Page 258 Treatment and prognosis......Page 259 References......Page 261 Clinical features......Page 265 Histopathology, immunophenotype, and molecular genetics......Page 267 Differential diagnosis of cutaneous follicle center lymphoma, diffuse type, from cutaneous diffuse large B‐cell lymphoma, leg t......Page 277 Prognosis......Page 278 References......Page 281 Chapter 14 Cutaneous marginal zone lymphoma (cutaneous MALT lymphoma) and variants......Page 284 Clinical features......Page 287 Histopathology, immunophenotype, and molecular genetics......Page 288 Prognosis......Page 296 Clinical features......Page 297 Histopathology, immunophenotype, and molecular genetics......Page 298 Prognosis......Page 299 Histopathology, immunophenotype, and molecular genetics......Page 300 Histopathology, immunophenotype, and molecular genetics......Page 302 Treatment and prognosis......Page 303 Clinical features......Page 304 References......Page 305 Chapter 15 Cutaneous diffuse large B‐cell lymphoma, leg type......Page 309 Clinical features......Page 310 Histopathology, immunophenotype, and molecular genetics......Page 311 Treatment......Page 318 Prognosis......Page 319 References......Page 322 Chapter 16 Intravascular large cell lymphomas......Page 325 Histopathology, immunophenotype, and molecular genetics......Page 326 Intravascular large B‐cell lymphoma colonizing hemangiomas......Page 328 Treatment and prognosis......Page 329 References......Page 333 Clinical features......Page 336 Treatment and prognosis......Page 337 Histopathology, immunophenotype, and molecular genetics......Page 339 Treatment and prognosis......Page 340 Histopathology, immunophenotype, and molecular genetics......Page 341 Treatment and prognosis......Page 343 Clinical features......Page 344 Treatment and prognosis......Page 345 Histopathology, immunophenotype, and molecular genetics......Page 347 Treatment and prognosis......Page 349 Histopathology, immunophenotype, and molecular genetics......Page 350 Treatment and prognosis......Page 351 Histopathology, immunophenotype, and molecular genetics......Page 352 Treatment and prognosis......Page 354 Histopathology, immunophenotype, and molecular genetics......Page 355 Histopathology, immunophenotype, and molecular genetics......Page 356 Treatment and prognosis......Page 357 Clinical features......Page 358 Treatment and prognosis......Page 359 References......Page 362 Chapter 18 Cutaneous lymphomas in immunosuppressed individuals......Page 366 Histopathology, immunophenotype, and molecular genetics......Page 367 Treatment and prognosis......Page 372 Treatment and prognosis......Page 374 CUTANEOUS LYMPHOPROLIFERATIVE DISORDERS IN OTHER IATROGENIC AND NON‐IATROGENIC IMMUNE DEFICIENCIES......Page 377 Treatment and prognosis......Page 378 References......Page 381 Clinical features......Page 386 Histopathology, immunophenotype, and molecular genetics......Page 387 PROGRESSION TO DIFFUSE LARGE B‐CELL LYMPHOMA (RICHTER SYNDROME)......Page 392 References......Page 395 Clinical features......Page 397 Histopathology, immunophenotype, and molecular genetics......Page 398 Immunophenotype......Page 401 Treatment and prognosis......Page 404 References......Page 412 Clinical features......Page 414 Histopathology, immunophenotype, and molecular genetics......Page 415 Immunophenotype......Page 418 Prognosis......Page 421 MATURE PLASMACYTOID DENDRITIC CELL PROLIFERATIONS ASSOCIATED WITH MYELOID NEOPLASMS......Page 422 References......Page 423 Chapter 22 Cutaneous manifestations of other leukemias......Page 426 References......Page 429 Clinical features......Page 431 Histopathology, immunophenotype, and molecular genetics......Page 432 Histopathology, immunophenotype, and molecular genetics......Page 435 Treatment and prognosis......Page 436 References......Page 439 Histopathology, immunophenotype, and molecular genetics......Page 442 Treatment and prognosis......Page 444 References......Page 447 Chapter 25 Cutaneous composite lymphomas......Page 448 Histopathology, immunophenotype, and molecular genetics......Page 449 References......Page 453 Chapter 26 Nonneoplastic cutaneous signs of systemic lymphomas......Page 455 References......Page 464 Chapter 27 Cutaneous lymphomas in children and adolescents......Page 466 References......Page 473 Chapter 28 Pseudolymphomas of the skin......Page 477 Lupus panniculitis......Page 513 Other pseudolymphomas associated with cutaneous lupus erythematosus......Page 515 References......Page 558 Chapter 29 The cutaneous “atypical lymphoid proliferation”......Page 566 References......Page 568 Index......Page 569