Sustainable synthesis of pharmaceuticals: using transition metal complexes as catalysts

Description

There is a growing interest in the development of sustainable processes for the synthesis of pharmaceuticals and this book bridges the divide between industrial examples and the fundamental chemistry. It explains the basic principles of using transition metal catalysis with several green approaches for the synthesis of pharmaceuticals. The topic is an important one for green chemistry and the chapters in this book on hydroformylation, green oxidation and olefin metathesis will also be of interest to both medicinal and organic chemists. Written by leading experts in the field, it provides a valuable and easy tool for scientists and industrialists who require information regarding this topic.  Read more... Abstract: There is a growing interest in the development of sustainable processes for the synthesis of pharmaceuticals and this book bridges the divide between industrial examples and the fundamental chemistry Content: Cover Preface Contents Chapter 1 Introduction 1.1 Introduction References Chapter 2 Transition Metals in Greener Pharmaceutical Chemistry 2.1 Transition Metals in Greener Pharmaceutical Chemistry References Chapter 3 Sustainable Synthesis of Pharmaceuticals Using Alternative Techniques: Microwave, Sonochemistry and Mechanochemistry 3.1 Introduction 3.2 Metrics 3.3 Microwave 3.4 Sonochemistry 3.5 Mechanochemistry 3.6 Conclusion Acknowledgements References Chapter 4 Carbonylation Reactions in the Synthesis of Pharmaceutically Active Compounds 4.1 Introduction. 4.2 Hydroalkoxycarbonylation of Alkenes4.3 Carbonylation of Aryl/Alkenyl Halides 4.3.1 Aminocarbonylation Reactions 4.3.2 Alkoxy-and Hydroxycarbonylations 4.3.3 Carbonylative Coupling Reactions 4.3.4 The Use of CO Equivalents 4.3.5 Industrial Applications 4.4 Oxidative Carbonylation Reactions 4.5 Conclusion and Outlook Acknowledgements References Chapter 5 Applications of Catalytic Hydroformylation in the Synthesis of Biologically Relevant Synthons and Drugs 5.1 Introduction 5.2 Hydroformylation Catalysts-A Historical Perspective. 5.3 Hydroformylation with Alternative Catalytic Systems5.4 Catalytic Hydroformylation in the Synthesis of Biologically Active Molecules: Selected Examples 5.4.1 Enantioselective and Diastereoselective Hydroformylation in Drug Synthesis 5.5 Conclusion and Future Perspective Acknowledgements References Chapter 6 Transfer Hydrogenation with Non-toxic Metals for Drug Synthesis 6.1 Introduction 6.2 Transfer Hydrogenation 6.2.1 Mechanistic Overview of Transfer Hydrogenation of Ketones 6.2.2 Transfer Hydrogenation with Cheap Metals. 6.2.3 Asymmetric Transfer Hydrogenation in the Synthesis of Bioactive Molecules6.3 Borrowing Hydrogen Methodology 6.4 Conclusion Acknowledgements References Chapter 7 Green Metal-catalysed Synthesis of Pharmaceutically Useful Asymmetric Epoxides and Sulfoxides 7.1 Epoxidation and Sulfoxidation: Introduction 7.2 Asymmetric Transition Metal-catalysed Epoxidation of Olefins 7.2.1 The Katsuki-Sharpless Asymmetric Epoxidation of Allylic Alcohols 7.2.2 The Jacobsen-Katsuki Epoxidation with M(salen) Complexes 7.2.3 M(bis-hydroxamic acid)-catalysed Epoxidations. 7.2.4 M(aminopyridine)-catalysed Epoxidations7.3 Transition Metal-catalysed Asymmetric Sulfoxidation 7.3.1 Asymmetric Sulfoxidation with Sharpless-type Catalysts 7.3.2 Asymmetric Sulfoxidation with Jacobsen-Katsuki-type Catalysts 7.3.3 Asymmetric Sulfoxidation with M(bis-hydroxamic) Catalysts 7.3.4 Catalytic ASO Processes Using Environmentally Sustainable O2 as TO 7.3.5 Catalytic ASO Processes Using Environmentally Sustainable H2O2 as TO 7.3.6 M(salen), M(salan) and M(salalen) Sulfoxidation with H2O2 as TO 7.4 Conclusion References.