Clinical Trials in Ovarian Cancer

Description

When a patient is diagnosed with a gynecological malignancy, she and her doctors must make urgent, high-risk decisions about her course of treatment. In selecting an appropriate plan of care, physicians must weigh the patient’s individual needs, the tumor’s specific characteristics, and the treatment’s potential side effects. Because there is no one-size-fits-all treatment solution, a plethora of clinical trials have been performed on ovarian cancer patients, but clinicians may struggle to keep up with this ever-growing body of research. Collecting and synthesizing research findings from a wide array of medical journal articles and book chapters, Clinical Trials in Ovarian Cancer provides physicians with an invaluable resource. Gynecologic oncologist Christine S. Walsh systematically outlines each of the seminal Phase III trials that have shaped the treatment of ovarian cancers, detailing the rationale for the trial, the patient population studied, treatment delivery methods, efficacy, toxicity, and trial conclusions. She provides a clear overview of established treatments, as well as still-controversial experimental approaches. The first book to organize this cutting-edge research into an easy-to-use reference, Clinical Trials in Ovarian Cancer should help medical personnel at all levels provide their patients with the highest standard of care. CHRISTINE S. WALSH is an associate professor and attending physician at Cedars-Sinai hospital in Los Angeles, California. She is also associate professor at the Geffen School of Medicine at UCLA. She serves as director for the gynecologic oncology fellowship program. Title Page ......Page 4 Copyright ......Page 5 Dedication ......Page 6 Contents ......Page 8 List of Tables......Page 10 Preface and Acknowledgments ......Page 12 GOG 7601 (Young, NEJM 1990) ......Page 14 GOG 7602 (Young, NEJM 1990) ......Page 18 GICOG Trials (Bolis, Ann Oncol 1995) ......Page 22 GOG 95 (Young, JCO 2003) ......Page 28 ICON1/ACTION Combined Analysis (Trimbos, JNCI 2003) ......Page 32 ACTION (Trimbos, JNCI 2003; Trimbos, JNCI 2010) ......Page 37 ICON1 (Colombo, JNCI 2003) ......Page 45 GOG 157 (Bell, Gynecol Oncol 2006) ......Page 50 GOG 157 Exploratory Analysis (Chan, Gynecol Oncol 2010) ......Page 56 GOG 47 (Omura, Cancer 1986) ......Page 59 GOG 52 (Omura, JCO 1989) ......Page 63 GOG 97 (McGuire, JCO 1995) ......Page 66 GOG 111 (McGuire, NEJM 1996) ......Page 70 GOG 104 (Alberts, NEJM 1996) ......Page 75 ICON2 (Lancet 1998) ......Page 79 GOG 132 (Muggia, JCO 2000) ......Page 83 Danish Netherlands Trial (Neijt, JCO 2000) ......Page 88 OV-10 (Piccart, JNCI 2000) ......Page 93 GOG 114 (Markman, JCO 2001) ......Page 99 ICON3 (Lancet 2002) ......Page 103 GOG 158 (Ozols, JCO 2003) ......Page 108 AGO/OVAR-3 (du Bois, JNCI 2003) ......Page 113 SCOTROC—Scottish Randomised Trial in Ovarian Cancer (Vasey, JNCI 2004) ......Page 118 GOG 172 (Armstrong, NEJM 2006) ......Page 122 GOG 182/ICON5 (Bookman, JCO 2009) ......Page 127 JGOG 3016 (Katsumata, Lancet 2009; Katsumata, Lancet Oncol 2013) ......Page 132 MITO-2 (Pignata, Oncology 2009; Pignata, JCO 2011) ......Page 139 AGO-OVAR9 (du Bois, JCO 2010) ......Page 145 OV16 (Hoskins, JNCI 2010) ......Page 150 ICON7 (Perren, NEJM 2011; Oza, Lancet Oncol 2015) ......Page 158 GOG 218 (Burger, NEJM 2011) ......Page 164 MITO-7 (Pignata, Lancel Oncol 2014) ......Page 170 EORTC-GCG 55865 (van der Burg, NEJM 1995) ......Page 175 GOG 152 (Rose, NEJM 2004) ......Page 181 EORTC 55971 (Vergote, NEJM 2010) ......Page 187 CHORUS (Kehoe, Lancet 2015) ......Page 191 GOG 178/SWOG 9701 (Markman, JCO 2003) ......Page 199 GOG 175 (Mannel, Gynecol Oncol 2011) ......Page 206 Topotecan Versus Paclitaxel (ten Bokkel, JCO 1997) ......Page 213 Doxil Study 30-49 (Gordon, JCO 2001; Gordon, Gyn Onc 2004) ......Page 220 ICON4/AGO- OVAR 2.2 (Parmar, Lancet 2003) ......Page 230 AGO-OVAR, NCIC CTG, EORTC GCG Trial (Pfisterer, JCO 2006) ......Page 235 Gemcitabine Versus PLD (Mutch, JCO 2007) ......Page 241 OVA-301 (Monk, JCO 2010) ......Page 248 CALYPSO (Pujade-Lauraine, JCO 2010) ......Page 255 OCEANS (Aghajanian, JCO 2012) ......Page 262 AURELIA (Pujade-Lauraine, JCO 2014) ......Page 269 Abbreviations......Page 276 References......Page 280 Index......Page 308 About the Author......Page 336