Iron Physiology and Pathophysiology in Humans

Description

Iron Physiology and Pathophysiology in Humans provides health professionals in many areas of research and practice with the most up-to-date and well-referenced volume on the importance of iron as a nutrient and its role in health and disease. This important new volume is the benchmark in the complex area of interrelationships between the essentiality of iron, its functions throughout the body, including its critical role in erythropoiesis, the biochemistry and clinical relevance of iron-containing enzymes and other molecules involved in iron absorption, transport and metabolism, he importance of optimal iron status on immune function, and links between iron and the liver, heart, brain and other organs. Moreover, the interactions between genetic and environmental factors and the numerous co-morbidities seen with both iron deficiency and iron overload in at risk populations are clearly delineated so that students as well as practitioners can better understand the complexities of these interactions. Key features of the volume include an in-depth index and recommendations and practice guidelines are included in relevant chapters. The volume contains more than 100 detailed tables and informative figures and up-to-date references that provide the reader with excellent sources of information about the critical role of iron nutrition, optimal iron status and the adverse clinical consequences of altered iron homeostasis. Iron Physiology and Pathophysiology in Humans is an excellent new text as well as the most authoritative resource in the field. Front Matter....Pages i-xxii Front Matter....Pages 1-1 Proteins of Iron Homeostasis....Pages 3-25 Cellular Iron Physiology....Pages 27-50 Regulation of Iron Metabolism in Mammalian Cells....Pages 51-62 Concentrating, Storing, and Detoxifying Iron: The Ferritins and Hemosiderin....Pages 63-78 Front Matter....Pages 79-79 Iron Nutrition....Pages 81-99 Intestinal Iron Absorption....Pages 101-116 Plasma Iron and Iron Delivery to the Tissues....Pages 117-139 Iron Salvage Pathways....Pages 141-171 Molecular Regulation of Systemic Iron Metabolism....Pages 173-190 Erythroid Iron Metabolism....Pages 191-209 Iron and the Reticuloendothelial System....Pages 211-231 Iron and the Immune System....Pages 233-248 Front Matter....Pages 249-249 Iron Deficiency....Pages 251-282 The Liabilities of Iron Deficiency....Pages 283-302 The Anemia of Inflammation and Chronic Disease....Pages 303-320 Disorders of Red Cell Production and the Iron-Loading Anemias....Pages 321-341 Front Matter....Pages 343-343 The Pathology of Hepatic Iron Overload....Pages 345-355 Hepatic Pathobiology of Iron Overload....Pages 357-383 HFE-Associated Hereditary Hemochromatosis....Pages 385-398 Non-HFE Hemochromatosis....Pages 399-416 Front Matter....Pages 343-343 Miscellaneous Iron-Related Disorders....Pages 417-439 Iron and Liver Disease....Pages 441-454 Neuropathology and Iron: Central Nervous System Iron Homeostasis....Pages 455-476 Iron Metabolism in Cancer and Infection....Pages 477-495 Front Matter....Pages 497-497 Estimation of Body Iron Stores....Pages 499-528 Genetic Testing for Disorders of Iron Homeostasis....Pages 529-565 The Properties of Therapeutically Useful Iron Chelators....Pages 567-590 Clinical Use of Iron Chelators....Pages 591-627 Front Matter....Pages 629-629 Mammalian Models of Iron Homeostasis....Pages 631-652 Yeast Iron Metabolism....Pages 653-667 Zebrafish Models of Heme Synthesis and Iron Metabolism....Pages 669-683 Back Matter....Pages 685-703