Peptide and Protein Drug Analysis

Description

Furthering efforts to simulate the potency and specificity exhibited by peptides and proteins in healthy cells, this remarkable reference supplies pharmaceutical scientists with a wealth of techniques for tapping the enormous therapeutic potential of these molecules-providing a solid basis of knowledge for new drug design. Provides a broad, comprehensive overview of peptides and proteins as mediators of cell movement, proliferation, differentiation, and communication. Written by more than 50 leading international authorities, Peptides and Protein Drug Analysis · discusses strategies for dealing with the complexity of peptides and proteins in conformational flexibility and amino acid sequence variability · analyzes drug formulations facilitated by solid-phase peptide synthesis and recombinant DNA technology · examines chemical purity analysis by high-pressure chromatographic, capillary electrophoretic, gel electrophoretic, and isoelectric focusing methods · highlights drug design elements derived from protein folding, bioinformatics, and computational chemistry · demonstrates uses of unnatural mutagenesis and combinatorial chemistry · explores mass spectrometry, protein sequence, and carbohydrate analysis · illustrates bioassays and other new functional analysis methods · surveys spectroscopic techniques such as ultraviolet, fluorescence, Fourier transform infrared, and nuclear magnetic resonance (NMR) · addresses ways of distinguishing between levels of therapeutic and endogenous agents in cells · reviews structural analysis tools such as ultracentrifugation and light, X-ray, and neutron scattering · and more! Featuring over 3400 bibliographic citations and more than 500 tables, equations, and illustrations, Peptide and Protein Drug Analysis is a must-read resource for pharmacists; pharmacologists; analytical, organic, and pharmaceutical chemists; cell and molecular biologists; biochemists; and upper-level undergraduate and graduate students in these disciplines.