ENGLISH

Tyrosine Phosphorylation/Dephosphorylation and Downstream Signalling

By E. H. Fischer , Ludwig M. G. Heilmeyer Jr. (eds.) , N. F. Zander , J. Lorenzen , C. Dadabay , D. E. Cool (auth.)

Book information

Publisher
Springer-Verlag Berlin Heidelberg
Year
1993
ISBN
978-3-642-78249-7, 978-3-642-78247-3
DOI
10.1007/978-3-642-78247-3
Language
english
Format
PDF
Filesize
16 MB (16817274 bytes)
Series
NATO ASI Series 76
Edition
1
Pages
376\375
Orientation
yes
Scanned
yes
Time added
2013-08-01 04:00:00
Biochemistrygeneral; Cell Biology; Cancer Research

Description

Nearly every cellular activity, such as cell growth, proliferation, protein synthesis, and nuclear division, is regulated by protein phosphorylation/dephosphorylation on tyrosine residues as initiation events.Synchronization occurs through interaction of protein tyrosine kinases and phosphatases. This book unveils signal pathways that connect extracellular signals with changes of phosphorylation state of target proteins allowing coordinated and integrated modulation of mitogenic signalling. Specifically, cascades involving protein serine/threonine kinases and connections to phosphoinositides derived second messengers are discussed.

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