ENGLISH

The Link Between Inflammation and Cancer: Wounds that do not heal

By Angus G. Dalgleish , Ken O’Byrne (auth.) , Angus G. Dalgleish MD , Burkhard Haefner PhD (eds.)

Book information

Publisher
Springer US
Year
2006
ISBN
0387262822, 9780387262826, 9780387262833, 0387262830
DOI
10.1007/b137303
Open Library ID
OL7444963M
Language
english
Format
PDF
Filesize
15 MB (16054285 bytes)
Series
Cancer Treatment and Research 130
Edition
1
Pages
254\260
Topic
Medicine Oncology
Time added
2011-06-04 13:46:07
Oncology;Cancer Research;Laboratory Medicine

Description

The transcription factor NF-kB has long been known to play a central role in the immune system by regulating the expression of key genes. Moreover, activation of this transcription factor helps a wide variety of cell types survive damage induced by pro-apoptotic stimuli. Owing to its critical role in the regulation of pro-inflammatory genes, NF-kB has long been regarded as a promising target for the discovery of anti-inflammatory drugs. More recently, NF-kB has emerged as a major culprit in a variety of human cancers mainly due to its ability to protect transformed cells from apoptosis. This finding should not have come as a surprise since there exists a link between inflammation and many types of cancer which was already suggested by Galen and later demonstrated by Virchow. This link, of crucial importance for the design of novel strategies for cancer treatment, is the topic of this book. Series Editor Cover Comments: "Inflammation is a known risk factor for a number of cancers. In this text, experts discuss the pathophysiology and molecular alterations that link these two processes. Potential therapeutics and preventive strategies are discussed." Steven T. Rosen, M.D. Series Editor

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