ENGLISH

Corticotropin-releasing factor : basic and clinical studies of a neuropeptide

By Nemeroff , Charles B.; De Souza , Errol B

Book information

Publisher
CRC Press
Year
1990
ISBN
0-8493-4550-2, 978-1-315-89183-5, 978-1-351-07093-5, 9780849345500
Language
english
Format
PDF
Filesize
66 MB (69305860 bytes)
Edition
1
Pages
365\376
Time added
2018-04-04 20:00:00
ACTH.;Neuropeptides.;Corticolibérine -- Effets ph

Description

This book provides a comprehensive summary of data from basic and clinical studies in support of a role for corticotropin-releasing factor (CRF) as a neurotransmitter in the mammalian central nervous system (CNS). It includes descriptions of the anatomy of CRF and its receptors in the CNS, as well as the characterization of CRF receptors and the second messenger systems mediating effects of CRF in the brain. It discusses the autonomic, behavioral, and electrophysiologic effects of CRF administration in the brain. This work also includes a section which covers the role of brain CRF in the etiology and pathophysiology of a variety of neurologic, psychiatric, and endocrine disorders. Endocrinologists, brain researchers, and neuroendocrinologists are among those who will find this reference both useful and interesting Content: Cloning and Distribution of Expression of the Rat Corticotropin-Releasing Factor (CRF) Gene. Distribution and Regulation of Corticotropin-Releasing Factor mRNA in Brain Using In Situ Hybridization Histochemistry. Central Nervous System CRF in Stress: Radioimmunassay Studies. Organization of CRF Immunore-active Cells and Fibers in the Rat Brain: Immunohistochemical Studies. The Organization and Possible Function of Amygdaloid Corticotropin Releasing Factor Pathways. CRF Recep-tors in the Rat CNS: Autoradiographic Localization. Brain CRF and Development. Neurotransmitter Regulation of CRF Secretion In Vitro . CRF Receptor in Brain: Characterization and Regulation. Characterization of Second Messengers Coupled to CRF Receptors in Brain. Receptors for Corticotropin-Releasing Factor. Regulation of ACTH Secretion by CRF. CRF Actions on Adenohypophyseal Hormone Secretion. Electrophysiology of CRF in Nervous Tissue. Effects of CRF on Spontaneous and Sensory-Evoked Activity of Locus Coe ruleus Neurons. CRF Effects on Brain EEG Activity: Im-plications for the Modulation of Normal and Abnormal Brain States. Behavioral Effects of CRF in Rats. Corticotropin Releasing Factor and Ingestive Behaviors. Behavioral and Endocrine Effects of CRF in Primates. Regulation of the Autonomic Nervous System by Corticotropin Releasing Factor. CRF: Central Nervous System Action to Influence Gastrointestinal Function and the Role in the Gastrointestinal Response to Stress. Clinical Studies with Ovine and Human CRF in Psychiatric Patients and Normal Controls. Corticotropin Releasing Factor: Cerebrospinal Fluid Studies. Abnormalities in Corticotropin Releasing Factor (CRF) in Neurodegenerative Diseases. Index.

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