ENGLISH

Metabotropic GPCRs: TGR5 and P2Y Receptors in Health and Diseases

By Senthilkumar Rajagopal , Murugavel Ponnusamy

Book information

Publisher
Springer Singapore
Year
2018
ISBN
978-981-13-1570-1, 978-981-13-1571-8
Language
english
Format
PDF
Filesize
3 MB (3119144 bytes)
Edition
1st ed.
Pages
XII, 76\85
Time added
2019-01-12 08:11:34
Biomedicine; Human Physiology; Receptors; Hepatolo

Description

This book will provide current understandings about two ubiquitously expressed metabotropic GPCRs, G-coupled purinoreceptor type 2 (P2Y) and Takeda G-protein-coupled bile acid receptor 5 (TGR5). G protein coupled receptors (GPCRs) are the largest family of proteins implicated in majority of cellular responses. The two receptor sub-families play a central role in many physiological functions as well as in many pathological conditions. This book offers up-to-date information on the physiological functions, signaling pathways and regulatory mechanisms of P2Y and TGR5 receptors. In addition, this book provides a comprehensive overview about the abnormalities of P2Y/TGR5 receptors and their contribution in the development and progression of pathological conditions. It also covers the currently available natural, chemical and pharmacological agents targeting these two receptor families and their therapeutic implications in P2Y and TGR5 associated disorders. This book is a valuable source for beginners and researchers to follow the rapidly progressing field of these two GPCR subfamily members. Front Matter ....Pages i-xii Overview of G-Protein Coupled Receptor (Senthilkumar Rajagopal, Murugavel Ponnusamy)....Pages 1-18 TGR5 Receptor (Senthilkumar Rajagopal, Murugavel Ponnusamy)....Pages 19-37 P2Y Receptor (Senthilkumar Rajagopal, Murugavel Ponnusamy)....Pages 39-55 Therapeutically Targeting TGR5 and P2Y Receptors (Senthilkumar Rajagopal, Murugavel Ponnusamy)....Pages 57-76

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