Rediscovering cancer: from mechanism to therapy

Description

"This volume presents a snapshot of some of the most important ongoing research in cancer. With cancer as the second leading cause of death worldwide, extensive research is going on globally to decipher the molecular mechanism underlying cancer that will help in finding better targets for drug therapy. The book brings together new research on molecular mechanism and cancer therapeutics in one place. With chapters from experts in their respective fields, chapters cover molecular mechanisms, etiology, prognosis, detection, and treatment of cancer. Emphasis has been given to the intricate mechanism behind the deregulation of cell division, disruption of cell cycle check points, mutation in oncogenes and tumor suppressor genes, apoptosis, and erratic cell signaling. The book discusses in detail topics such as angiogenesis and tumor microenvironment, which are increasingly receiving attention, especially in the field of neoplastic vascularization and metastasis. The book also includes chapters detailing the current understanding and the future perspective of cancer stem cells. Rediscovering Cancer: From Mechanism to Therapy also includes some recent research on the therapeutic aspects of cancer. Chapters related to immunotherapy, chemotherapy, and use of chitosan-based nanoparticles for cancer therapy are included, with emphasis on preventive measures for cancer. Overall, this informative volume covers the present knowledge and future direction on the field of cancer research."--Provided by publisher.  Read more... Abstract: "This volume presents a snapshot of some of the most important ongoing research in cancer. With cancer as the second leading cause of death worldwide, extensive research is going on globally to decipher the molecular mechanism underlying cancer that will help in finding better targets for drug therapy. The book brings together new research on molecular mechanism and cancer therapeutics in one place. With chapters from experts in their respective fields, chapters cover molecular mechanisms, etiology, prognosis, detection, and treatment of cancer. Emphasis has been given to the intricate mechanism behind the deregulation of cell division, disruption of cell cycle check points, mutation in oncogenes and tumor suppressor genes, apoptosis, and erratic cell signaling. The book discusses in detail topics such as angiogenesis and tumor microenvironment, which are increasingly receiving attention, especially in the field of neoplastic vascularization and metastasis. The book also includes chapters detailing the current understanding and the future perspective of cancer stem cells. Rediscovering Cancer: From Mechanism to Therapy also includes some recent research on the therapeutic aspects of cancer. Chapters related to immunotherapy, chemotherapy, and use of chitosan-based nanoparticles for cancer therapy are included, with emphasis on preventive measures for cancer. Overall, this informative volume covers the present knowledge and future direction on the field of cancer research."--Provided by publisher Content: Genetic instability in cancer / Gloria Ravegnini, Patrizia Hrelia, and Sabrina Angelini -- Oncogenesis and telomerase activity in cancer / Sutapa Mukherjee, Madhumita Roy, and Jaydip Biswas -- Cell cycle checkpoints in cancer / Sreeparna Chakraborty and Abhik Sen -- Angiogenesis, its importance and implication in tumor growth and progression and in anticancer therapy : an update / Chandrani Sarkar and Debanjan Chakroborty -- The tumor microenvironment and metastasis / Sonia Chadha -- Apoptosis : a regulatory mechanism in cancer / Sutapa Mukherjee, Apurba Mukherjee, Souvick Biswas, and Madhumita Roy -- Cytoplasmic signaling circuitry : an important trait of cancer / Subhra Dash, K. Lohitesh, and Sudeshna Mukherjee -- Cancer : an overview of risk factors / Sayali Mukherjee and Shabana Siddique -- Single nucleotide polymorphisms as susceptibility markers for cancer / Suresh Kumar Yadav and Somali Sanyal -- Dietary phytochemicals in the prevention and therapy of cancer : modulation of molecular targets / Shamee Bhattacharjee -- Health benefits and preventive effects of common beverages in cancer / Vivek Kumar Gaur, Sanjay Gupta, and Janmejai Kumar Srivastava -- Cancer chemotherapy / Sonal Srivastava, Sakshi Mishra, Jayant Dewangan, Aman Divakar, Prabhash Kumar Pandey, and Srikanta Kumar Rath -- Non-coding RNAs : the new reins in malignancies / Deba Prasad Mandal -- Epigenetics in cancer prevention and therapy : role of phytochemicals / Sajid Khan, Samriddhi Shukla, and Syed Musthapa Meeran -- Cancer stem cell : current understanding and future perspectives / Sonal Srivastava, Jayant Dewangan, Divya Tandon, and Srikanta Kumar Rath -- Tumor microenvironment and cancer stem cells : therapeutic -- Potential of epigenetic inhibitors to target CSCS / Anup Kumar Singh, Priyank Chaturvedi, and Dipak Datta -- Nanoparticles in cancer therapy / Madhuchanda Banerjee -- Cancer immunotherapy : extending new horizons in cancer treatment / Deba Prasad Mandal.