Liquid Chromatography Time-of-Flight Mass Spectrometry: Principles, Tools, and Applications for Accurate Mass Analysis, Volume 173

Description

Time of flight mass spectrometry identifies the elements of a compound by subjecting a sample of ions to a strong electrical field. Illuminating emerging analytical techniques in high-resolution mass spectrometry, Liquid Chromatography Time-of-Flight Mass Spectrometry shows readers how to analyze unknown and emerging contaminants?such as antibiotics, steroids, analgesics?using advanced mass spectrometry techniques. The text combines theoretical discussion with concrete examples, making it suitable for analytical chemists, environmental chemists, organic chemists, medicinal chemists, university research chemists, and graduate and post-doctorate students.Content: Chapter 1 Accurate Mass Measurements With Orthogonal Axis Time?of?Flight Mass Spectrometry (pages 1–15): John C. FjeldstedChapter 2 The Mass Defect, Isotope Clusters, and Accurate Mass for Elemental Determination (pages 17–31): E. Michael Thurman and Imma FerrerChapter 3 Ion Compositions Determined with Increasing Simplicity (pages 33–56): Andrew H. Grange and G. Wayne SovocoolChapter 4 Existence and Use of Accurate Mass Databases and Elemental Composition Tools for Target and Non?Target Analyses (pages 57–70): Imma Ferrer and E. Michael ThurmanChapter 5 Use of UPLC?(Q)TOF MS for Rapid Screening of Organic Micropollutants in Water (pages 71–87): Felix Hernandez, Juan V. Sancho and Maria IbanezChapter 6 The Use of Accurate Mass, Isotope Ratios, and MS/MS for the Analysis of PPCPs in Water (pages 89–102): Michael C. ZumwaltChapter 7 Applications of LC/TOF?MS in the Environmental Field: When Did It Start and Where Is It Going? (pages 103–111): Imma Ferrer and E. Michael ThurmanChapter 8 Liquid Chromatography and Ambient Ionization Time?of?Flight Mass Spectrometry for the Analysis of Genuine and Counterfeit Pharmaceuticals (pages 113–132): Facundo M. Fernandez, Christina Y. Hampton, Leonard Nyadong, Arti Navare and Mark KwasnikChapter 9 Quantitative Analysis of Veterinary Drug Residues by Sub 2?µm Particulate High?Performance Liquid Chromatography Columns and Time?of?Flight Mass Spectrometry (UPLC?TOF) (pages 133–149): Anton KaufmannChapter 10 Industrial Applications of Liquid Chromatography Time?of?Flight Mass Spectrometry (pages 151–172): Jeffrey R. Gilbert, Jesse L. Balcer, Scott A. Young, Dan A. Markham, Dennis O. Duebelbeis and Paul LewerChapter 11 Comprehensive Toxicological and Forensic Drug Screening by LC/TOF?MS (pages 173–195): Ilkka Ojanpera, Anna Pelander and Suvi OjanperaChapter 12 Application of UPLC/TOF?MS for Residue Analysis of Veterinary Drugs and Growth?Promoting Agents in Products of Animal Origin (pages 197–228): Alida(Linda)A.M. StolkerChapter 13 Accurate Mass Measurements With a Reflectron Time?of?Flight Mass Spectrometer and the Direct Analysis in Real Time (DART) Interface for the Identification of Unknown Compounds below Masses of 500 DA (pages 229–245): O. David Sparkman, Patrick R. Jones and Matthew CurtisChapter 14 Comparison Of LC/TOF?MS and LC/MS?MS for the Analysis of 100 Pesticides in Food: Finding the “Crossover Point” (pages 247–257): E. Michael Thurman, Imma Ferrer, Jerry A. Zweigenbaum and Paul A. Zavitsanos