ENGLISH

Left-Right Asymmetry in Vertebrate Development

By Ph.D. Maria L. López-Gracia , Prof. Dr. Marian Ros (auth.)

Book information

Publisher
Springer-Verlag Berlin Heidelberg
Year
2007
ISBN
978-3-540-36347-7, 978-3-540-36348-4
DOI
10.1007/978-3-540-36348-4
Language
english
Format
PDF
Filesize
2 MB (2076123 bytes)
Series
Advances in Anatomy Embryology and Cell Biology 188
Edition
1
Pages
126\135
Orientation
yes
Scanned
yes
Time added
2013-10-22 02:17:58
Human Physiology

Description

Externally the vertebrate body plan presents a bilateral symmetry in relation to the midline. However, inside the body the distribution of the visceral organs follows a very particular pattern that is not symmetrical in relation to the midline. The last 10 years have seen remarkable advances in our understanding of how the internal asymmetries typical of the vertebrate body are established and controlled. The use of different development models has permitted to uncover fascinating ways of creating asymmetry, like the activity of the nodal cilia. A host of studies has also unravelled the involvement of many genes in the left right patterning pathway. Based on this knowledge the genetic basis of human laterality defects are beginning to be revealed. It is a major challenge now to understand how all these genes control left right development as well as the complex set of interactions established between them.

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