ENGLISH

Tumor Liquid Biopsies

By Florence Schaffner , Jean-Louis Merlin , Nikolas von Bubnoff

Book information

Publisher
Springer International Publishing
Year
2020
ISBN
978-3-030-26438-3, 978-3-030-26439-0
Language
english
Format
PDF
Filesize
7 MB (7249543 bytes)
Series
Recent Results in Cancer Research 215
Edition
1st ed. 2020
Pages
VI, 368\365
Time added
2020-02-08 04:41:33
Medicine & Public Health; Oncology; Pathology; Can

Description

This book is a comprehensive guide to the techniques, clinical applications, and benefits of the different forms of liquid biopsy employed in patients with a variety of tumor types, including lung, breast and colorectal cancer. Offering detailed explanations, it discusses the how changes in tumors can be tracked using these cutting-edge technologies, which enable the detection and analysis of diverse circulating biomarkers: tumor cells, tumor DNA, tumor RNA (free or in exosomes), and fluid biomarkers identifiable by means of targeted proteomics. The use of such advanced technologies is enabling us to tackle questions and problems in a way that was not possible just a few years ago. We now have at our disposal an effective means of overcoming the problem of intratumor heterogeneity, which has limited the value of conventional biopsy approaches. As a consequence, oncology practice is about to change radically, toward truly personalized precision medicine. This book provides both clinicians and researchers with a thorough and up-to-date overview of progress in the field. Front Matter ....Pages i-vi Front Matter ....Pages 1-1 Pathophysiology of Tumor Cell Release into the Circulation and Characterization of CTC (Tilman Todenhöfer, Klaus Pantel, Arnulf Stenzl, Stefan Werner)....Pages 3-24 Circulating Tumor Cell Enrichment Technologies (Mert Boya, Chia-Heng Chu, Ruxiu Liu, Tevhide Ozkaya-Ahmadov, Ali Fatih Sarioglu)....Pages 25-55 Genetic Analysis of Circulating Tumour Cells (Michael Paul Kolinsky, Nikolas Stoecklein, Maryou Lambros, Veronica Gil, Daniel Nava Rodrigues, Suzanne Carreira et al.)....Pages 57-76 Quantitative Analysis of Circulating Tumor Cells Using RNA-Based Digital Scoring (Mark Kalinich, Tanya T. Kwan, Mehmet Toner, Daniel A. Haber, Shyamala Maheswaran)....Pages 77-88 Circulating Tumor Cells: High-Throughput Imaging of CTCs and Bioinformatic Analysis (Kevin Keomanee-Dizon, Stephanie N. Shishido, Peter Kuhn)....Pages 89-104 Circulating Tumour Cells in Lung Cancer (Francesca Chemi, Sumitra Mohan, Ged Brady)....Pages 105-125 Circulating Tumor Cells in Breast Cancer (Diana H. Liang, Carolyn Hall, Anthony Lucci)....Pages 127-145 Clinical Applications of Circulating Tumor Cells in Breast Cancer (Erin F. Cobain, Costanza Paoletti, Jeffrey B. Smerage, Daniel F. Hayes)....Pages 147-160 Front Matter ....Pages 161-161 Pathophysiology of ctDNA Release into the Circulation and Its Characteristics: What Is Important for Clinical Applications (Nickolas Papadopoulos)....Pages 163-180 Enrichment and Analysis of ctDNA (Pauline Gilson)....Pages 181-211 Capturing Tumor Heterogeneity and Clonal Evolution by Circulating Tumor DNA Profiling (Florian Scherer)....Pages 213-230 Review ctDNA and Breast Cancer (Florian Clatot)....Pages 231-252 Cell-Free DNA in the Management of Colorectal Cancer (Alexandre Harlé)....Pages 253-261 Dynamic Treatment Stratification Using ctDNA (Joana Vidal, Alvaro Taus, Clara Montagut)....Pages 263-273 Front Matter ....Pages 275-275 Circulating miRNAs as Biomarker in Cancer (Gitte Brinch Andersen, Jörg Tost)....Pages 277-298 Circulating MicroRNAs as Potential Biomarkers for Lung Cancer (Sabrina Müller, Florian Janke, Steffen Dietz, Holger Sültmann)....Pages 299-318 Extracellular Vesicles: Recent Developments in Technology and Perspectives for Cancer Liquid Biopsy (Irina Nazarenko)....Pages 319-344 Front Matter ....Pages 345-345 Computational Analysis of DNA and RNA Sequencing Data Obtained from Liquid Biopsies (Francesco Marass, Francesc Castro-Giner, Barbara Maria Szczerba, Katharina Jahn, Jack Kuipers, Nicola Aceto et al.)....Pages 347-368

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