ENGLISH

G-CSF Receptor

By Nagata S.

Book information

Year
2000
DOI
10.1006/rwcy.2000.20006
Language
english
Format
PDF
Filesize
89 kB (90807 bytes)
Pages
8\8
Library
mexmat
Time added
2009-07-20 03:45:11

Description

The G-CSF receptor is a type I membrane protein which belongs to the cytokine receptor superfamily, and is specifically expressed in mature neutrophils and neutrophilic precursors. Binding of G-CSF to G-CSFR induces its dimerization. The dimerized receptor transduces growth and differentiation signals which are mediated by the N-terminal and C-terminal halves of the G-CSFR cytoplasmic region. G-CSF activates JAK family kinases, which cause tyrosine phosphorylation of STAT family transcription factors. STATs then stimulate proliferation, and induce differentiation of neutrophilic precursor cells. Genetic defects in the G-CSFR gene cause severe neutropenia (Kosimann's syndrome).

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