ENGLISH

Reviews of Physiology, Biochemistry and Pharmacology, Volume 135

By D. C. Foster , B. J. Wedel , S. W. Robinson (auth.)

Book information

Publisher
Springer-Verlag Berlin Heidelberg
Year
1999
ISBN
978-3-540-64779-9, 978-3-540-68704-7
DOI
10.1007/BFb0033667
Language
english
Format
PDF
Filesize
6 MB (6014900 bytes)
Series
Reviews of Physiology, Biochemistry and Pharmacology 135
Edition
1
Pages
211\212
Orientation
yes
Scanned
yes
Time added
2013-08-20 18:36:03
Biochemistrygeneral; Cell Biology

Description

This special volume provides up-to-date information on research dealing with the regulation of the biosynthesis and degradation of cyclic GMP and with the regulation of physiological systems by cyclic GMP. The publication of this volume could not have come at a more appropriate time, with significant work in this area having led to our current understanding of the role of nitric oxide in signal transduction, and the 1998 Nobel Prize in Medicine and Physiology for Furchgott, Murad and Ignarro. Moreover, the introduction in early 1998 of sildenafil (Viagra), a selective inhibitor of a cyclic GMP phosphodiesterase, for the treatment of erectile dysfunction in men represents the first successful therapeutic application of an agent designed to alter the activity of a molecular target in a cyclic GMP pathway.

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