Head and Neck Pathology: A Volume in the Series: Foundations in Diagnostic Pathology, 2e

Description

Commended, Basic and Clinical Sciences, BMA Awards 2007 This volume in the Foundations in Diagnostic Pathology Series packs today's most essential head and neck pathology know-how into a compact, high-yield format! Its pragmatic, well-organised approach, abundant full-colour illustrations, and at-a-glance tables make the information easy to access. It offers hundreds of full-colour illustrations that demonstrate the key features of a wide variety of pathologic lesions.Easily review normal histology before examining abnormal findings so you can avoid false positives. Reach accurate diagnostic conclusions easily with a consistent, user-friendly format that explores each entity's clinical features, pathologic features (gross and microscopic), ancillary studies, differential diagnoses, and prognostic and therapeutic considerations. Apply the latest diagnostic criteria for all of the most commonly seen neoplastic and non-neoplastic conditions of the larynx, hypopharynx, and trachea; nasal cavity, paranasal sinuses, and nasopharynx; oral cavity and oropharynx; salivary glands; ear; and temporal bone. Gain a superb visual understanding of important histologic features with hundreds of full-color illustrations representing a wide variety of pathologic lesions. Quickly reference key information with convenient, at-a-glance clinical and pathologic boxes throughout. Get concise, complete coverage of both head and neck pathology and related endocrine pathology (including salivary, thyroid, and thymus diseases and disorders) - all in one convenient book. Access the entire book online at www.excpertconsult.com, with a downloadable image bank, references linked to PubMed, and the ability to search across the entire Expert Consult library. The Foundations in Diagnostic Pathology Series answers the call for fresh, affordable, and easy-to-use guidance. Each region-specific volume provides all of the most essential information on the pathologic entities encountered in practice. Series Editor: John R. Goldblum, MD, FACP, FASCP, FACG Learn today's most essential head and neck pathology know-how in a compact, high-yield format! Front cover Head and neck pathology a volume in the series foundations in diagnostic pathology second edition Copyright Dedication Contributors Foreword Preface Acknowledgments Table of contents 1 Non-neoplastic lesions of the nasal cavity, paranasal sinuses, and nasopharynx ■ Rhinosinusitis Clinical features Pathologic features Gross findings Microscopic findings Differential diagnosis Prognosis and therapy ■ Sinonasal polyps Clinical features Radiologic findings Pathologic findings Gross findings Microscopic findings Differential diagnosis Prognosis and therapy ■ Nasal glial heterotopia Clinical features Radiologic features Pathologic features Gross findings Microscopic findings Ancillary studies Differential diagnosis Prognosis and therapy ■ Allergic fungal sinusitis (eosinophilic fungal rhinosinusitis) Clinical features Pathologic features Gross findings Microscopic findings Ancillary studies Differential diagnosis Prognosis and therapy ■ Rhinoscleroma Clinical features Pathologic features Gross features Microscopic findings Ancillary studies Prognosis and therapy ■ Rhinosporidiosis Clinical features Pathologic features Gross features Microscopic features Differential diagnosis Prognosis and treatment ■ Wegener granulomatosis Clinical features Radiologic features Pathologic features Gross findings Microscopic findings Ancillary studies Differential diagnosis Prognosis and therapy ■ Respiratory epithelial adenomatoid hamartoma Clinical features Radiologic features Pathologic features Gross findings Microscopic findings Differential diagnosis Prognosis and therapy ■ Myospherulosis Clinical features Pathologic features Differential diagnosis Prognosis and therapy Suggested readings Rhinosinusitis Sinonasal Polyps Nasal Glial Heterotopia Infections Wegener Granulomatosis Respiratory Epithelial Adenomatoid Hamartoma 2 Benign neoplasms of the nasal cavity, paranasal sinuses, and nasopharynx ■ Schneiderian papillomas Clinical features Radiologic features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Lobular capillary hemangioma (pyogenic granuloma) Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Glomangiopericytoma (sinonasal-type hemangiopericytoma) Clinical features Radiologic features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Nasopharyngeal angiofibroma Clinical features Radiologic features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Ectopic pituitary adenoma Clinical features Radiologic features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy Suggested readings Schneiderian papillomas Lobular capillary hemangioma (pyogenic granuloma) Glomangiopericytoma (sinonasal-type hemangiopericytoma) Nasopharyngeal angiofibroma Ectopic pituitary adenoma 3 Malignant neoplasms of the nasal cavity, paranasal sinuses, and nasopharynx ■ Squamous cell carcinoma Clinical features Radiologic features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Sinonasal adenocarcinoma Clinical features ■ Sinonasal undifferentiated carcinoma Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Nasopharyngeal carcinoma Clinical features Radiologic features Laboratory studies Pathologic features Prognosis and therapy ■ Malignant mucosal melanoma Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Olfactory neuroblastoma Clinical features Radiographic features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Extranodal nk/t-cell lymphoma, nasal type Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Mesenchymal malignancies Rhabdomyosarcoma Fibrosarcoma Leiomyosarcoma Angiosarcoma ■ Ewing sarcoma Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Teratocarcinosarcoma Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy Suggested readings Squamous cell carcinoma Sinonasal adenocarcinoma Sinonasal undifferentiated carcinoma Nasopharyngeal carcinoma Malignant mucosal melanoma Olfactory neuroblastoma Extranodal NK/T-cell lymphoma, nasal type Mesenchymal malignancies Rhabdomyosarcoma Fibrosarcoma Leiomyosarcoma Angiosarcoma Ewing Sarcoma Teratocarcinosarcoma 4 Non-neoplastic lesions of the larynx, hypopharynx, and trachea ■ Vocal cord polyps and nodules Clinical features Pathologic features Differential diagnosis Prognosis and therapy ■ Contact ulcer Clinical features Pathologic features Differential diagnosis Prognosis and therapy ■ Amyloidosis Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Cysts of the larynx (including laryngocele) Clinical features Pathologic features Differential diagnosis Prognosis and therapy ■ Reactive epithelial changes Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy Suggested readings Vocal cord polyps and nodules Contact Ulcer Amyloidosis Cysts of the larynx (including laryngocele) Reactive epithelial changes 5 Benign neoplasms of the larynx, hypopharynx, and trachea ■ Squamous papilloma/papillomatosis Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Granular cell tumor Clinical features Radiologic features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Adult rhabdomyoma Clinical features Pathologic features Ancillary studies Other ancillary studies Differential diagnosis Prognosis and therapy ■ Chondroma Clinical features Radiologic features Pathologic features Differential diagnosis Prognosis and therapy Suggested readings Squamous papilloma/papillomatosis Granular cell tumor Adult rhabdomyoma Chondroma 6 Malignant neoplasms of the larynx, hypopharynx, and trachea ■ Precursor squamous lesions Clinical features Pathologic features Differential diagnosis Prognosis and therapy ■ Squamous cell carcinoma Clinical features Pathologic features Differential diagnosis Prognosis and therapy ■ Neuroendocrine carcinoma Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Chondrosarcoma Clinical features Radiologic features Pathologic features Differential diagnosis Prognosis and therapy ■ Metastatic/secondary tumors Clinical features Pathologic features Differential diagnosis Prognosis and treatment Suggested readings Precursor squamous lesions Squamous cell carcinoma and variants Neuroendocrine carcinoma Chondrosarcoma Metastatic/secondary tumors 7 Non-neoplastic lesions of the oral cavity and oropharynx ■ Fordyce granules Clinical features Pathologic features Differential diagnosis Prognosis and therapy ■ Amalgam tattoo Clinical features Radiologic features Pathologic features Differential diagnosis Prognosis and therapy ■ Ectopic thyroid Clinical features Radiologic features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Oral hairy leukoplakia Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Infections Clinical features Pathologic features Candida (including median rhomboid glossitis) Herpes simplex virus 1 Actinomycosis Differential diagnosis Prognosis and therapy ■ Oral lichen planus Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Mucous membrane pemphigoid (cicatricial pemphigoid) Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Pemphigus vulgaris Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Recurrent aphthous stomatitis Clinical features Pathologic features Differential diagnosis Prognosis and therapy ■ Traumatic ulcerative granuloma Clinical features Pathologic features Differential diagnosis Prognosis and therapy Suggested readings Fordyce granules Amalgam tattoo Ectopic thyroid Oral hairy leukoplakia Infections Oral lichen planus Mucous membrane pemphigoid (cicatrical pemphigoid) Pemphigus vulgaris Recurrent aphthous stomatitis Traumatic ulcerative granuloma 8 Benign neoplasms of the oral cavity and oropharynx ■ Fibroma Clinical features Pathologic features Differential diagnosis Prognosis and therapy ■ Squamous papilloma (including verruca and condyloma) Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Focal epithelial hyperplasia Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Lobular capillary hemangioma Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Peripheral ossifying fibroma Clinical features Pathologic features Differential diagnosis Prognosis and therapy ■ Peripheral giant cell granuloma Clinical features Radiologic features Pathologic features Differential diagnosis Prognosis and therapy ■ Congenital granular cell epulis Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy Suggested readings Fibroma Squamous papilloma (including verruca and condyloma) Focal epithelial hyperplasia Lobular capillary hemangioma Peripheral ossifying fibroma Peripheral giant cell granuloma Congenital granular cell epulis 9 Malignant neoplasms of the oral cavity and oropharynx ■ Squamous cell carcinoma Clinical features Radiologic features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Kaposi sarcoma Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy Suggested readings Squamous cell carcinoma Kaposi sarcoma 10 Non-neoplastic lesions of the salivary glands ■ Developmental, including heterotopia and oncocytosis Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Mucus retention cyst, mucocele, and sialolithiasis Clinical features Radiologic features Pathologic features Differential diagnosis Prognosis and therapy ■ Necrotizing sialometaplasia Clinical features Pathologic features Differential diagnosis Prognosis and therapy ■ Benign lymphoepithelial lesion Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Lymphoepithelial cyst Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy Suggested readings Developmental, including heterotopia and oncocytosis Mucus retention cyst, mucocele, and sialolithiasis Necrotizing sialometaplasia Benign lymphoepithelial lesion Lymphoepithelial cyst 11 Benign neoplasms of the salivary glands ■ Pleomorphic adenoma Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Basal cell adenoma Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Canalicular adenoma Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Oncocytoma Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Papillary cystadenoma lymphomatosum (warthin tumor) Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Sebaceous adenoma/lymphadenoma Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Hemangioma Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy Suggested readings Pleomorphic adenoma Basal cell adenoma Canalicular adenoma Oncocytoma Papillary cystadenoma lymphomatosum (warthin tumor) Sebaceous adenoma/lymphadenoma Hemangioma 12 Malignant neoplasms of the salivary glands ■ Adenocarcinoma, not otherwise specified Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Mucoepidermoid carcinoma Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Acinic cell carcinoma Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Adenoid cystic carcinoma Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Polymorphous low-grade adenocarcinoma Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Epithelial-myoepithelial carcinoma Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Salivary duct carcinoma Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Carcinoma ex pleomorphic adenoma Clinical features Pathologic features Differential diagnosis Prognosis and therapy ■ Extranodal marginal zone b-cell lymphoma of salivary glands Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Sialoblastoma Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy Suggested readings Adenocarcinoma, not otherwise specified Mucoepidermoid carcinoma Acinic cell carcinoma Adenoid cystic carcinoma Polymorphous low-grade adenocarcinoma Epithelial-myoepithelial carcinoma Salivary duct carcinoma Carcinoma ex pleomorphic adenoma Extranodal marginal zone b-cell lymphoma of salivary glands Sialoblastoma Uncommon carcinomas Undifferentiated carcinomas 13 Non-neoplastic lesions of the gnathic bones ■ Osteomyelitis Clinical features Radiologic features Pathologic features Differential diagnosis Prognosis and therapy ■ Dentigerous cyst Clinical features Radiologic features Pathologic features Differential diagnosis Prognosis and therapy ■ Radicular cyst Clinical features Radiologic features Pathologic features Differential diagnosis Prognosis and therapy ■ Fibrous dysplasia Clinical features Radiologic features Pathologic features Differential diagnosis Prognosis and therapy ■ Osteoradionecrosis Clinical features Radiologic features Pathologic features Differential diagnosis Prognosis and therapy ■ Simple bone cyst Clinical features Radiologic features Pathologic features Differential diagnosis Prognosis and therapy ■ Nasopalatine duct cyst Clinical features Radiologic features Pathologic features Differential diagnosis Prognosis and therapy ■ Tori Clinical features Radiologic features Pathologic features Differential diagnosis Prognosis and therapy ■ Cherubism Clinical features Radiologic features Pathologic features Differential diagnosis Prognosis and therapy ■ Osseous dysplasia Clinical features Radiologic features Pathologic features Differential diagnosis Prognosis and therapy Suggested readings Osteomyelitis Dentigerous cyst Radicular cyst Fibrous dysplasia Osteoradionecrosis Simple bone cyst Nasopalatine duct cyst Tori Cherubism Osseous dysplasia 14 Benign neoplasms of the gnathic bones ■ Ossifying fibroma Clinical features Radiologic features Pathologic features Differential diagnosis Prognosis and therapy ■ Juvenile/active ossifying fibroma Clinical features Radiologic features Pathologic features Differential diagnosis Prognosis and therapy ■ Central odontogenic fibroma Clinical features Radiologic features Pathologic features Differential diagnosis Prognosis and therapy ■ Osteoblastoma Clinical features Radiologic features Pathologic features Differential diagnosis Prognosis and therapy ■ Cementoblastoma Clinical features Radiologic features Pathologic features Differential diagnosis Prognosis and therapy ■ Ameloblastoma Clinical features Radiologic features Pathologic features Differential diagnosis Prognosis and therapy ■ Keratocystic odontogenic tumor Clinical features Radiologic features Pathologic features Differential diagnosis Prognosis and therapy ■ Calcifying epithelial odontogenic tumor Clinical features Radiologic features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Adenomatoid odontogenic tumor Clinical features Radiologic features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Central giant cell lesion Clinical features Radiologic features Pathologic features Differential diagnosis Prognosis and therapy ■ Odontoma (complex and compound) Clinical features Radiologic features Pathologic features Differential diagnosis Prognosis and therapy Suggested readings Ossifying fibroma Juvenile/active ossifying fibroma Central odontogenic fibroma Osteoblastoma Cementoblastoma Ameloblastoma Keratocystic odontogenic tumor Calcifying epithelial odontogenic tumor Adenomatoid odontogenic tumor Central giant cell lesion Odontoma (complex and compound) 15 Malignant neoplasms of the gnathic bones ■ Osteosarcoma Clinical features Radiologic features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Chondrosarcoma Clinical features Radiologic features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Multiple myeloma Clinical features Radiologic features Pathologic features Differential diagnosis Prognosis and therapy ■ Metastatic neoplasms Clinical features Radiologic features Pathologic features Differential diagnosis Prognosis and therapy Suggested readings Osteosarcoma Chondrosarcoma Multiple myeloma Metastatic neoplasms 16 Non-neoplastic lesions of the ear and temporal bone ■ First branchial cleft anomalies Clinical features Pathologic features Differential diagnosis Prognosis and therapy ■ Cystic chondromalacia Clinical features Pathologic features Differential diagnosis Prognosis and therapy ■ Chondrodermatitis nodular helicis Clinical features Pathologic features Differential diagnosis Prognosis and therapy ■ Angiolymphoid hyperplasia with eosinophilia Clinical features Pathologic features Differential diagnosis Prognosis and therapy ■ Relapsing polychondritis Clinical features Pathologic features Differential diagnosis Prognosis and therapy ■ Langerhans cell histiocytosis Clinical findings Radiologic features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Cholesteatoma Clinical features Radiologic features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Cholesterol granuloma Clinical features Radiologic features Pathologic features Differential diagnosis Prognosis and therapy Suggested readings 17 Benign neoplasms of the ear and temporal bone ■ Ceruminous adenoma Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Peripheral nerve sheath tumor (schwannoma) Clinical features Radiologic features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Paraganglioma Clinical features Radiologic features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Meningioma Clinical features Radiologic features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Neuroendocrine adenoma of the middle ear (middle ear adenoma) Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Endolymphatic sac tumor Clinical features Radiologic features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy Suggested readings Ceruminous adenoma Peripheral nerve sheath tumor (schwannoma) Paraganglioma Meningioma Neuroendocrine adenoma of the middle ear (middle ear adenoma) Endolymphatic sac tumor 18 Malignant neoplasms of the ear and temporal bone ■ Squamous cell carcinoma (external and middle ear) Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Ceruminous adenocarcinoma Clinical features Radiologic features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Metastatic neoplasms Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy Suggested readings Squamous cell carcinoma (external and middle ear) Ceruminous adenocarcinoma Metastatic neoplasms 19 Non-neoplastic lesions of the neck (soft tissue, bone, and lymph node) ■ Branchial cleft anomalies Clinical features Radiologic features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Cat scratch disease (granulomatous inflammation) Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Nodular fasciitis Clinical features Radiologic features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Sinus histiocytosis with massive lymphadenopathy (rosai-dorfman disease) Clinical features Radiologic features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Langerhans cell histiocytosis Clinical features Radiologic features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy Suggested readings Branchial cleft anomalies Cat scratch disease (granulomatous inflammation) Nodular fasciitis Sinus histiocytosis with massive lymphadenopathy (rosai-dorfman disease) Langerhans cell histiocytosis 20 Benign neoplasms of the neck (soft tissue, bone, and lymph node) ■ Lymphangioma (cystic hygroma) Clinical features Pathologic features Differential diagnosis Prognosis and therapy ■ Teratoma Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Spindle cell lipoma/pleomorphic lipoma Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy Suggested readings Lymphangioma (cystic hygroma) Teratoma Spindle cell lipoma/pleomorphic lipoma 21 Malignant neoplasms of the neck (soft tissue, bone, and lymph node) ■ Metastatic cystic squamous cell carcinoma Clinical features Radiologic features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Chordoma Clinical features Radiologic features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Synovial sarcoma Clinical features Radiologic features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Metastatic neoplasm of unknown primary Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy Suggested readings Metastatic cystic squamous cell carcinoma Chordoma Synovial sarcoma Metastatic neoplasm of unknown primary 22 Non-neoplastic lesions of the thyroid gland ■ Thyroglossal duct cyst Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Struma ovarii Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Ultimobranchial body remnants and other intrathyroidal inclusions Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Acute thyroiditis Clinical features Pathologic features Differential diagnosis Prognosis and therapy ■ Granulomatous thyroiditis Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Palpation thyroiditis Clinical features Pathologic features Differential diagnosis Prognosis and therapy ■ Riedel disease (riedel thyroiditis) Clinical features Radiologic features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Chronic lymphocytic thyroiditis (hashimoto thyroiditis) Clinical features Radiologic features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Diffuse hyperplasia (graves disease) Clinical features Radiologic features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Adenomatoid nodule (nodular goiter) Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Dyshormonogenetic goiter Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Amyloid goiter Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy Suggested readings Thyroglossal duct cyst Struma ovarii Ultimobranchial body remnants and other intrathyroidal inclusions Acute thyroiditis Granulomatous thyroiditis Palpation thyroiditis Riedel disease (riedel thyroiditis) Chronic lymphocytic thyroiditis (hashimoto thyroiditis) Diffuse hyperplasia (graves disease) Adenomatoid nodule (nodular goiter) Dyshormonogenetic goiter 23 Benign neoplasms of the thyroid gland ■ Follicular adenoma Clinical features Radiologic features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Teratoma Clinical features Radiologic features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Hyalinizing trabecular tumor Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy Suggested readings Follicular adenoma Teratoma Hyalinizing trabecular tumor 24 Malignant neoplasms of the thyroid gland ■ Papillary carcinoma Clinical features Radiologic features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Follicular carcinoma Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Undifferentiated carcinoma Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Medullary carcinoma Clinical features Radiologic features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Primary thyroid lymphoma Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Uncommon thyroid neoplasms ■ Metastatic neoplasms Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy Suggested readings Papillary carcinoma (including variants) Follicular carcinoma Undifferentiated carcinoma Medullary carcinoma Primary thyroid lymphoma Uncommon thyroid neoplasms Mucoepidermoid carcinoma Squamous cell carcinoma Spindle cell tumor with thymus-like differentiation Carcinoma showing thymus-like differentiation Mesenchymal tumors Metastatic neoplasms 25 Non-neoplastic lesions of the parathyroid gland ■ General considerations ■ Primary chief cell hyperplasia Clinical features Radiologic features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Secondary and tertiary parathyroid hyperplasia Clinical features Pathologic features Differential diagnosis Prognosis and therapy Suggested readings Primary chief cell hyperplasia Secondary and tertiary parathyroid hyperplasia 26 Benign neoplasms of the parathyroid gland ■ Parathyroid adenoma Clinical features Radiographic features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy Suggested readings Parathyroid adenoma 27 Malignant neoplasms of the parathyroid gland ■ Parathyroid carcinoma Clinical features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy ■ Metastatic tumors Clinical features Pathologic features Prognosis and therapy Suggested readings Parathyroid carcinoma Metastatic tumors 28 Diseases of the paraganglia system ■ Paraganglioma Clinical features Radiologic features Pathologic features Ancillary studies Differential diagnosis Jugulotympanic paraganglioma Laryngeal paraganglioma Vagal and carotid body tumors Prognosis and therapy ■ Malignant paraganglioma Clinical features Radiologic features Pathologic features Ancillary studies Differential diagnosis Prognosis and therapy Suggested readings Paraganglioma Malignant paraganglioma Index